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External data borrowing in clinical trial designs has increased in recent years. This is accomplished in the Bayesian framework by specifying informative prior distributions. To mitigate the impact of potential inconsistency (bias) between…

Bayesian dynamic borrowing has become an increasingly important tool for evaluating the consistency of regional treatment effects which is a key requirement for local regulatory approval of a new drug. It helps increase the precision of…

统计方法学 · 统计学 2026-01-06 Xin Zhang , Hui Zhang , Satrajit Roychoudhury

In Bayesian analysis, the posterior follows from the data and a choice of a prior and a likelihood. One hopes that the posterior is robust to reasonable variation in the choice of prior and likelihood, since this choice is made by the…

统计方法学 · 统计学 2015-12-09 Ryan Giordano , Tamara Broderick , Michael Jordan

Bayesian clinical trials can benefit of available historical information through the elicitation of informative prior distributions. Concerns are however often raised about the potential for prior-data conflict and the impact of Bayes test…

统计方法学 · 统计学 2022-12-01 Silvia Calderazzo , Annette Kopp-Schneider

Many modern experiments, such as microarray gene expression and genome-wide association studies, present the problem of estimating a large number of parallel effects. Bayesian inference is a popular approach for analyzing such data by…

统计方法学 · 统计学 2018-10-26 J G Liao , Arthur Berg , Timothy L McMurry

Robust Bayesian analysis has been mainly devoted to detecting and measuring robustness w.r.t. the prior distribution. Many contributions in the literature aim to define suitable classes of priors which allow the computation of variations of…

统计理论 · 数学 2025-09-04 Antonio Di Noia , Fabrizio Ruggeri , Antonietta Mira

In Bayesian analysis, the posterior follows from the data and a choice of a prior and a likelihood. One hopes that the posterior is robust to reasonable variation in the choice of prior, since this choice is made by the modeler and is often…

统计方法学 · 统计学 2016-12-07 Ryan Giordano , Tamara Broderick , Michael Jordan

Use of historical control data to augment a small internal control arm in a randomized control trial (RCT) can lead to significant improvement of the efficiency of the trial. It introduces the risk of potential bias, since the historical…

统计方法学 · 统计学 2022-10-05 Jixian Wang , Hongtao Zhang , Ram Tiwari

There is a large body of evidence that decision makers frequently depart from Bayesian updating. This paper introduces a model, robust maximum likelihood (RML) updating, where deviations from Bayesian updating are due to multiple…

理论经济学 · 经济学 2025-12-17 Elchin Suleymanov

A common assumption in machine learning is that samples are independently and identically distributed (i.i.d). However, the contributions of different samples are not identical in training. Some samples are difficult to learn and some…

机器学习 · 计算机科学 2021-11-23 Ou Wu , Weiyao Zhu , Yingjun Deng , Haixiang Zhang , Qinghu Hou

Although linear regression models are fundamental tools in statistical science, the estimation results can be sensitive to outliers. While several robust methods have been proposed in frequentist frameworks, statistical inference is not…

统计方法学 · 统计学 2020-07-15 Shintaro Hashimoto , Shonosuke Sugasawa

Federated Bayesian neural networks require fixing a prior on the model parameters together with a likelihood. Eliciting meaningful priors on the weight space of modern overparameterized models is notoriously difficult, and misspecification…

机器学习 · 计算机科学 2026-05-19 Boning Zhang , Matteo Zecchin , Mingzhao Guo , Dongzhu Liu , Osvaldo Simeone

Principal component regression uses principal components as regressors. It is particularly useful in prediction settings with high-dimensional covariates. The existing literature treating of Bayesian approaches is relatively sparse. We…

统计方法学 · 统计学 2020-01-28 Philippe Gagnon , Mylène Bédard , Alain Desgagné

Robustness is important for sequential decision making in a stochastic dynamic environment with uncertain probabilistic parameters. We address the problem of using robust MDPs (RMDPs) to compute policies with provable worst-case guarantees…

机器学习 · 计算机科学 2018-11-16 Reazul Hasan Russel , Marek Petrik

This paper develops a methodology for robust Bayesian inference through the use of disparities. Metrics such as Hellinger distance and negative exponential disparity have a long history in robust estimation in frequentist inference. We…

统计方法学 · 统计学 2012-11-28 Giles Hooker , Anand Vidyashankar

Multilevel regression and poststratification (MRP) is a popular method for addressing selection bias in subgroup estimation, with broad applications across fields from social sciences to public health. In this paper, we examine the…

统计方法学 · 统计学 2023-03-06 Yajuan Si

Mendelian randomization is the use of genetic variants to make causal inferences from observational data. The field is currently undergoing a revolution fuelled by increasing numbers of genetic variants demonstrated to be associated with…

统计方法学 · 统计学 2018-08-31 Stephen Burgess , Jack Bowden , Frank Dudbridge , Simon G Thompson

We propose a robust hypothesis testing procedure for the predictability of multiple predictors that could be highly persistent. Our method improves the popular extended instrumental variable (IVX) testing (Phillips and Lee, 2013; Kostakis…

统计方法学 · 统计学 2024-01-03 Xiaosai Liao , Xinjue Li , Qingliang Fan

Random backpropagation (RBP) is a variant of the backpropagation algorithm for training neural networks, where the transpose of the forward matrices are replaced by fixed random matrices in the calculation of the weight updates. It is…

机器学习 · 计算机科学 2017-12-25 Pierre Baldi , Peter Sadowski , Zhiqin Lu

Because of the widespread existence of noise and data corruption, recovering the true regression parameters with a certain proportion of corrupted response variables is an essential task. Methods to overcome this problem often involve…

机器学习 · 计算机科学 2023-01-10 Zheyi Fan , Zhaohui Li , Jingyan Wang , Dennis K. J. Lin , Xiao Xiong , Qingpei Hu
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