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Mapping conformational heterogeneity of macromolecules presents a formidable challenge to X-ray crystallography and cryo-electron microscopy, which often presume its absence. This has severely limited our knowledge of the conformations…

生物物理 · 物理学 2015-05-14 P. Schwander , R. Fung , G. N. Phillips , A. Ourmazd

Cryo-EM is a transformational paradigm in molecular biology where computational methods are used to infer 3D molecular structure at atomic resolution from extremely noisy 2D electron microscope images. At the forefront of research is how to…

定量方法 · 定量生物学 2025-06-12 Shayan Shekarforoush , David B. Lindell , Marcus A. Brubaker , David J. Fleet

Class imbalance refers to the significant difference in the number of samples from different classes within a dataset, making it challenging to identify minority class samples correctly. This issue is prevalent in real-world classification…

机器学习 · 计算机科学 2024-08-08 Yi-Yang Shangguan , Shi-Shun Chen , Xiao-Yang Li

The function of protein, RNA, and DNA is modulated by fast, dynamic exchanges between three-dimensional conformations. Conformational sampling of biomolecules with exact and nullspace inverse kinematics, using rotatable bonds as revolute…

机器人学 · 计算机科学 2016-07-27 Rasmus Fonseca , Dominik Budday , Henry van den Bedem

Scanning Transmission Electron Microscopy (STEM) enables the observation of atomic arrangements at sub-angstrom resolution, allowing for atomically resolved analysis of the physical and chemical properties of materials. However, due to the…

计算机视觉与模式识别 · 计算机科学 2025-04-04 Hesong Li , Ziqi Wu , Ruiwen Shao , Tao Zhang , Ying Fu

We propose a method to reconstruct the 3-D molecular structure from micrographs collected at just one sample tilt angle in the random conical tilt scheme in cryo-electron microscopy. Our method uses autocorrelation analysis on the…

数据分析、统计与概率 · 物理学 2021-01-12 Ti-Yen Lan , Nicolas Boumal , Amit Singer

The present paper introduces the $\eta$ and {\eta} connections in order to add regional information on $\lambda$-flat zones, which only take into account a local information. A top-down approach is considered. First $\lambda$-flat zones are…

计算机视觉与模式识别 · 计算机科学 2016-03-29 Guillaume Noyel , Jesus Angulo , Dominique Jeulin

Single particle cryogenic electron microscopy (cryo-EM) is an imaging technique capable of recovering the high-resolution 3-D structure of biological macromolecules from many noisy and randomly oriented projection images. One notable…

生物大分子 · 定量生物学 2024-01-30 Andy Zhang , Oscar Mickelin , Joe Kileel , Eric J. Verbeke , Nicholas F. Marshall , Marc Aurèle Gilles , Amit Singer

This paper presents a detailed evaluation of the envelope-tracking adaptive integral method (ET-AIM), an FFT-accelerated algorithm for analyzing electromagnetic scattering. ET-AIM is used to solve progressively more complex benchmark…

计算物理 · 物理学 2014-09-01 Guneet Kaur , Ali E. Yilmaz

Rotational symmetry is a defining feature of many tomography systems, including computed tomography (CT) and emission computed tomography (ECT), where detectors are arranged in a circular or periodically rotating configuration. This study…

医学物理 · 物理学 2025-02-05 Yaogong Zhang , Fang-Fang Yin , Lei Zhang

Electrocardiogram (ECG) diagnosis remains challenging due to limited labeled data and the need to capture subtle yet clinically meaningful variations in rhythm and morphology. We present CREMA (Contrastive Regularized Masked Autoencoder), a…

机器学习 · 计算机科学 2025-08-22 Junho Song , Jong-Hwan Jang , DongGyun Hong , Joon-myoung Kwon , Yong-Yeon Jo

Tomography can be used to reveal internal properties of a 3D object using any penetrating wave. Advanced tomographic imaging techniques, however, are vulnerable to both systematic and random errors associated with the experimental…

数值分析 · 数学 2019-02-08 Anthony P. Austin , Zichao Wendy Di , Sven Leyffer , Stefan M. Wild

The use of ray projections to reconstruct images is a common technique in medical imaging. Dealing with incomplete data is particularly important when a patient is vulnerable to potentially damaging radiation or is unable to cope with the…

神经与进化计算 · 计算机科学 2024-06-04 Mohammad Majid al-Rifaie , Tim Blackwell

We introduce COT-FM, a general framework that reshapes the probability path in Flow Matching (FM) to achieve faster and more reliable generation. FM models often produce curved trajectories due to random or batchwise couplings, which…

计算机视觉与模式识别 · 计算机科学 2026-03-17 Chiensheng Chiang , Kuan-Hsun Tu , Jia-Wei Liao , Cheng-Fu Chou , Tsung-Wei Ke

Electrical Capacitance Tomography (ECT) is an imaging technique providing the distribution of permittivity in a medium by the mean of electrodes. As for any imaging systems, the reachable spatial resolution is a key parameter. In this paper…

仪器与探测器 · 物理学 2015-03-05 Jérôme Lucas , Cédric Margo , Yacine Oussar , Stéphane Holé

We show that the symmetries of image formation by scattering enable graph-theoretic manifold-embedding techniques to extract structural and timing information from simulated and experimental snapshots at extremely low signal. The approach…

计算物理 · 物理学 2011-09-27 Peter Schwander , Chun Hong Yoon , Abbas Ourmazd , Dimitrios Giannakis

High-quality, large-scale data is essential for robust deep learning models in medical applications, particularly ultrasound image analysis. Diffusion models facilitate high-fidelity medical image generation, reducing the costs associated…

图像与视频处理 · 电气工程与系统科学 2024-04-01 Pooria Ashrafian , Milad Yazdani , Moein Heidari , Dena Shahriari , Ilker Hacihaliloglu

The AMIAS/RISE framework formulates emission tomography as a probabilistic inverse problem in which reconstructed images are sampled from a distribution defined by the measurement model and counting statistics. In this work we present a…

This paper addresses the challenging problem of parameter estimation for multicomponent complex exponential signals, commonly known as sums of cisoids. Traditional approaches that estimate individual component parameters face significant…

信息论 · 计算机科学 2025-12-01 Huiguang Zhang

Beampattern synthesis seeks to optimize array weights to shape radiation patterns, playing a critical role in various wireless applications. In addition to theoretical advancements, recent hardware innovations have facilitated new avenues…

信号处理 · 电气工程与系统科学 2025-03-07 Pinjun Zheng , Md. Jahangir Hossain , Anas Chaaban
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