相关论文: Integrating Endothelial-Derived Hyperpolarizing Si…
Disturbances in calcium homeostasis in a cardiac myocyte can lead to calcium-overload conditions and abnormal calcium releases, which occur primarily in the following two phases of the action potential (AP): (a) triggered or late calcium…
The accumulation of potassium in the extracellular space surrounding nerve cells is a fundamental aspect of biophysics that has garnered significant attention in recent research. This phenomenon holds implications for various neurological…
Mucociliary clearance in mammals serves as the primary defense mechanism for removing particulate matter deposited in the pulmonary airways. Dysfunctions in this process are linked to serious respiratory diseases and can hinder effective…
We applied a periodic magnetic field of frequency 16 Hz and amplitude 16 nT to a human I_Ks channel, expressed in a Xenopus oocyte and varied the membrane depolarization between -100 mV and +100 mV. We observed a maximal increase of about…
Negative activation volumes for dielectric relaxation are rarely reported in solid state physics and are limited to atomic scale processes. Broadband Dielectric Spectroscopy on heterogeneous systems, such as polycrystalline calcite and…
Atherosclerosis is a major cardiovascular complication of diseases associated with elevated oxidative stress such as type 2 diabetes and metabolic syndrome. In these situations, low density lipoproteins (LDL) undergo oxidation. Oxidized LDL…
Metabolic substrates, such as oxygen and glucose, are rapidly delivered to the cell through filtration across microvessels walls. Modelling this important process is complicated by the coupling between flow and transport equations, which…
Minimally invasive interventions performed inside brain vessels with the synergistic use of microcatheters pushed over guidewires have revolutionized the way aneurysms, stroke, arteriovenous malformations, brain tumors and other…
Excitability is an attribute of life, and is a driving force in the descent of complexity. Cellular electrical activity as realized by membrane proteins that act as either channels or transporters is the basis of excitability. Electrical…
The function of many membrane-enclosed intracellular structures relies on release of diffusing particles that exit through narrow pores or channels in the membrane. The rate of release varies with pore size, density, and length of the…
Any micropolar fluid containing magnetic particles, such as blood or ferrofluids, subjected to an external magnetic field experiences a magnetic torque due to the misalignment between particle magnetization and the magnetic field. This…
Cell extravasation is a crucial step of the metastatic cascade. In this process, the circulating tumor cells inside the blood vessels adhere to the cell monolayer of the blood vessel wall and passes through it, which allows them to invade…
NMDA receptors (NMDA-R) typically contribute to excitatory synaptic transmission in the central nervous system. While calcium influx through NMDA-R plays a critical role in synaptic plasticity, experimental evidence indicates that…
Effects of mechanical stress on the permeability of vascular endothelium are important to normal physiology and may be critical in the development of atherosclerosis, where they can account for the patchy arterial distribution of the…
Synaptic vesicle transport by motor proteins along microtubules is a crucial active process underlying neuronal communication. It is known that microtubules are destabilized by tau-hyperphosphorylation, which causes tau proteins to detach…
Projection neurons in the dorsal horn relay nociceptive input to supraspinal centers. During central sensitization, a subset of them switches from tonic firing to plateau potentials with sustained afterdischarges, a change that requires…
In cases when it is desirable to transport medication through blood vessels, especially when dealing with brain cancer being confronted with the narrow arteries in the brain, the blood-brain barrier makes the medical treatment difficult.…
The accumulation of potassium in the narrow space outside nerve cells is a classical subject of biophysics that has received much attention recently. It may be involved in potassium accumulation \textcolor{black}{including} spreading…
Multiple Sclerosis (MS) is a disorder that usually appears in adults in their thirties. It has a prevalence that ranges between 2 and 150 per 100 000. Epidemiological studies of MS have provided hints on possible causes for the disease…
BACKGROUND: Primary aldosteronism is the most common form of secondary hypertension. The most frequent genetic cause of aldosterone-producing adenomas is somatic mutations in the potassium channel KCNJ5. They affect the ion selectivity of…