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Understanding disease progression is a central clinical challenge with direct implications for early diagnosis and personalized treatment. While recent generative approaches have attempted to model progression, key mismatches remain:…

计算机视觉与模式识别 · 计算机科学 2026-02-17 Hao Chen , Rui Yin , Yifan Chen , Qi Chen , Chao Li

Conditional medical image generation plays an important role in many clinically relevant imaging tasks. However, existing methods still face a fundamental challenge in balancing inference efficiency, patient-specific fidelity, and…

计算机视觉与模式识别 · 计算机科学 2026-04-22 Zirong Li , Siyuan Mei , Weiwen Wu , Andreas Maier , Lina Gölz , Yan Xia

Analyzing temporal developments is crucial for the accurate prognosis of many medical conditions. Temporal changes that occur over short time scales are key to assessing the health of physiological functions, such as the cardiac cycle.…

Longitudinal imaging is able to capture both static anatomical structures and dynamic changes in disease progression toward earlier and better patient-specific pathology management. However, conventional approaches rarely take advantage of…

Glioma, an aggressive brain malignancy characterized by rapid progression and its poor prognosis, poses significant challenges for accurate evolution prediction. These challenges are exacerbated by sparse, irregularly acquired longitudinal…

计算机视觉与模式识别 · 计算机科学 2025-09-16 Aghiles Kebaili , Romain Modzelewski , Jérôme Lapuyade-Lahorgue , Maxime Fontanilles , Sébastien Thureau , Su Ruan

Learning medical visual representations from image-report pairs through joint learning has garnered increasing research attention due to its potential to alleviate the data scarcity problem in the medical domain. The primary challenges stem…

计算机视觉与模式识别 · 计算机科学 2025-12-09 Jun Wang , Lixing Zhu , Xiaohan Yu , Abhir Bhalerao , Yulan He

Disease progression simulation is a crucial area of research that has significant implications for clinical diagnosis, prognosis, and treatment. One major challenge in this field is the lack of continuous medical imaging monitoring of…

图像与视频处理 · 电气工程与系统科学 2023-10-06 Kaizhao Liang , Xu Cao , Kuei-Da Liao , Tianren Gao , Wenqian Ye , Zhengyu Chen , Jianguo Cao , Tejas Nama , Jimeng Sun

Accurate diagnosis of glaucoma is challenging, as early-stage changes are subtle and often lack clear structural or appearance cues. Most existing approaches rely on a single modality, such as fundus or optical coherence tomography (OCT),…

计算机视觉与模式识别 · 计算机科学 2026-03-24 Zhiwei Wang , Yuxing Li , Meilu Zhu , Defeng He , Edmund Y. Lam

Disease-modifying management aims to prevent deterioration and progression of the disease, not just relieve symptoms. Unfortunately, the development of necessary therapies is often hampered by the failure to recognize the presymptomatic…

Medical imaging plays a vital role in modern diagnostics; however, interpreting high-resolution radiological data remains time-consuming and susceptible to variability among clinicians. Traditional image processing techniques often lack the…

计算机视觉与模式识别 · 计算机科学 2025-10-21 Melika Filvantorkaman , Maral Filvan Torkaman

Deep learning-based computer-aided diagnosis is gradually deployed to review and analyze medical images. However, this paradigm is restricted in real-world clinical applications due to the poor robustness and generalization. The issue is…

计算机视觉与模式识别 · 计算机科学 2022-03-22 Yurong Chen

Longitudinal study designs are indispensable for studying disease progression. Inferring covariate effects from longitudinal data, however, requires interpretable methods that can model complicated covariance structures and detect nonlinear…

机器学习 · 统计学 2022-10-27 Juho Timonen , Henrik Mannerström , Aki Vehtari , Harri Lähdesmäki

Models of misfolded proteins (MP) aim at discovering the bio-mechanical propagation properties of neurological diseases (ND) by identifying plausible associated dynamical systems. Solving these systems along the full disease trajectory is…

定量方法 · 定量生物学 2019-01-31 Sara Garbarino , Marco Lorenzi

Accurate and interpretable prediction of estimated glomerular filtration rate (eGFR) is essential for managing chronic kidney disease (CKD) and supporting clinical decisions. Recent advances in Large Multimodal Models (LMMs) have shown…

机器学习 · 计算机科学 2025-07-31 Peng-Yi Wu , Pei-Cing Huang , Ting-Yu Chen , Chantung Ku , Ming-Yen Lin , Yihuang Kang

Longitudinal imaging is capable of capturing the static ana\-to\-mi\-cal structures and the dynamic changes of the morphology resulting from aging or disease progression. Self-supervised learning allows to learn new representation from…

This study addresses the challenges of symptom evolution complexity and insufficient temporal dependency modeling in Parkinson's disease progression prediction. It proposes a unified prediction framework that integrates structural…

机器学习 · 计算机科学 2025-08-22 Jiacheng Hu , Bo Zhang , Ting Xu , Haifeng Yang , Min Gao

Longitudinal imaging analysis tracks disease progression and treatment response over time, providing dynamic insights into treatment efficacy and disease evolution. Radiomic features extracted from medical imaging can support the study of…

应用统计 · 统计学 2025-05-14 Isabella Cama , Michele Piana , Cristina Campi , Sara Garbarino

Serial Magnetic Resonance Imaging (MRI) exams are often performed in clinical practice, offering shared anatomical and motion information across imaging sessions. However, existing reconstruction methods process each session independently…

图像与视频处理 · 电气工程与系统科学 2025-10-07 Jingjia Chen , Hersh Chandarana , Daniel K. Sodickson , Li Feng

The ability to estimate how a tumor might evolve in the future could have tremendous clinical benefits, from improved treatment decisions to better dose distribution in radiation therapy. Recent work has approached the glioma growth…

Cardiac structure segmentation from echocardiogram videos plays a crucial role in diagnosing heart disease. The combination of multi-view echocardiogram data is essential to enhance the accuracy and robustness of automated methods. However,…

计算机视觉与模式识别 · 计算机科学 2023-09-21 Ziyang Zheng , Jiewen Yang , Xinpeng Ding , Xiaowei Xu , Xiaomeng Li