相关论文: Monitoring Single DNA Docking Site Activity With S…
Whispering gallery mode microlasers are known for their high Q-factors, characteristic emission spectra and sensitivity to local refractive index changes. This sensitivity combined with the ability of various cell types to internalise these…
Ultrasensitive optical detection of nanometer-scaled particles is highly desirable for applications in early-stage diagnosis of human diseases, environmental monitoring, and homeland security, but remains extremely difficult due to ultralow…
Spectroscopy is the basic tool for studying molecular physics and realizing bio-chemical sensing. However, it is challenging to realize sub-femtometer resolution spectroscopy over broad bandwidth. In this paper, broadband and…
We report a highly efficient source of narrow-band photon pairs based on parametric down-conversion in a crystalline whispering gallery mode resonator. Remarkably, each photon of a pair is strictly emitted into a single spatial and temporal…
Solid-state nanopores are emerging platforms for single-molecule protein sequencing due to their tolerance to hash physiology environment and compatibility with different electrical and optical detection methods. However, they suffer from…
Current optical detection schemes for single molecules require light absorption, either to produce fluorescence or direct absorption signals. This severely limits the range of molecules that can be detected, because most molecules are…
In combining DNA nanotechnology and high-bandwidth single-molecule detection in nanopipettes, we demonstrate an all-electric, label-free hybridisation sensor for short DNA sequences (< 100 nt). Such short fragments are known to occur as…
Sensing with optical whispering gallery modes (WGMs) is a rapidly developing detection method in modern microfluidics research. This method explores the perturbations of spectra of WGMs propagating along the wall of an optical…
Label-free detection techniques for single particles and molecules play an important role in basic science, disease diagnostics, and nanomaterial investigations. While traditional fluorescence-based methods offer powerful tools for single…
The accurate measurement of complex liquid permittivity in a frequency range provides important information on liquid properties in comparison to single frequency permittivity investigations. The multifrequency microwave characterization…
Nanopore based sequencing has demonstrated significant potential for the development of fast, accurate, and cost-efficient fingerprinting techniques for next generation molecular detection and sequencing. We propose a specific multi-layered…
Protein phosphorylation provides a dynamic readout of cellular signaling yet remains difficult to detect at low abundance and stoichiometry. Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) using particle-in-pore plasmonic…
Whispering gallery modes are known for having orbital angular momentum, however the interplay of local spin density, orbital angular momentum, and the near-field interaction with quantum emitters is much less explored. Here, we study the…
Navigation, bio-tracking devices and gravity gradiometry are amongst the diverse range of applications requiring ultrasensitive measurements of acceleration. We describe an accelerometer that exploits the dispersive and dissipative coupling…
We, for the first time, report the detection and the size measurement of single nanoparticles (i.e. polystyrene) in aquatic environment using mode splitting in a whispering gallery mode (WGM) optical resonator, namely a microtoroid…
DNA-interacting proteins have roles multiple processes, many operating as molecular machines which undergo dynamic metastable transitions to bring about their biological function. To fully understand this molecular heterogeneity, DNA and…
Micro and nanoscale particles are crucial in various fields, from biomedical imaging to environmental processes. While conventional spectroscopy and microscopy methods for characterizing these particles often involve bulky equipment and…
We report a theoretical study of clusters of evanescently-coupled 2D whispering-gallery (WG) mode optical micro-cavities (termed "photonic molecules") as chemosensing and biosensing platforms. Photonic molecules (PMs) supporting modes with…
Direct observation of single-molecule interactions and dynamic configurations in situ is a demanding challenge but crucial for both chemical and biological systems. However, optical microscopy that relies on bulk measurements cannot meet…
Nanoparticle-induced modifications of the spectrum of whispering-gallery-modes (WGM) of optical spheroidal resonators are studied theoretically. Combining an ab initio solution of a single resonator problem with a dipole approximation for…