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Single-molecule detection enables direct observation of individual biomolecular events, providing mechanistic insights into biological processes and offering a powerful tool for disease diagnostics. However, the fundamental scale mismatch…

光学 · 物理学 2025-10-14 Guifeng Li , Chaoyang Gong

Optical whispering gallery mode (WGM) resonators are a powerful and versatile tool used in many branches of science. Fine tuning of the central frequency and line width of individual resonances is however desirable in a number of…

In this study, an integrated low-cost and complexity mm-wave structure of Whispering Gallery Mode (WGM) is proposed for sensing the glucose levels in mimicking aquatic solutions of concentrations similar to type 2 diabetics. The bio-sensor…

应用物理 · 物理学 2019-09-30 Ala Eldin Omer , George Shaker , Safieddin Safavi-Naeini

We analyze a whispering gallery mode biosensor with a metallic nanorod bound to its surface. It is found that a localized surface plasmon resonance in the nanorod can reduce the optical mode volume of the resonator by as much as four orders…

光学 · 物理学 2017-02-01 Jon D. Swaim , Joachim Knittel , Warwick P. Bowen

Whispering gallery modes (WGMs), circulating modes near the surface of a spheroidal material, have been known to exhibit high quality factors for both acoustic and electromagnetic waves. Here, we report an electro-optomechanical system,…

Optoplasmonic methods capable of single protein detection so far rely on analyte immobilization in order to facilitate detection [1-6]. These detection schemes, even if they facilitate transient single-molecule detection [7,8] via…

光学 · 物理学 2022-01-21 M. D. Baaske , N. Asgari , D. Punj , M. Orrit

In whispering gallery mode (WGM) resonators light is guided by continuous total internal reflection along a curved surface. Fabricating such resonators from an optically nonlinear material one takes advantage of their exceptionally high…

Monitoring the kinetics and conformational dynamics of single enzymes is crucial in order to better understand their biological functions as these motions and structural dynamics are usually unsynchronized among the molecules. Detecting the…

生物物理 · 物理学 2017-05-29 Eugene Kim , Martin D. Baaske , Isabel Schuldes , Peter S. Wilsch , Frank Vollmer

We develop a compact whispering-gallery-mode (WGM) sensing system by integrating multiple components, including a tunable laser, a temperature controller, a function generator, an oscilloscope, a photodiode detector, and a testing computer,…

光学 · 物理学 2016-11-23 Xiangyi Xu , Xuefeng Jiang , Guangming Zhao , Lan Yang

We propose a molecular optomechanical platform to generate robust entanglement among bosonic modes-photons, phonons, and plasmons-under ambient conditions. The system integrates an ultrahigh-Q whispering-gallery-mode (WGM) optical resonator…

量子物理 · 物理学 2025-05-28 Hong-Yun Yu , Ya-Feng Jiao , Jie Wang , Feng Li , Bin Yin , Tian Jiang , Qi-Rui Liu , Hui Jing , Ke Wei

A microfluidic whispering gallery mode (WGM) biosensing system is proposed for enhanced delivery and detection of target molecules. A microtoroid resonator coupled to a tapered optical fiber is immersed within a microfluidic channel, and…

光学 · 物理学 2018-04-09 Kiran Khosla , Jon D. Swaim , Joachim Knittel , Warwick P. Bowen

Whispering gallery mode (WGM) resonators are an important building block for linear, nonlinear and quantum optical experiments. In such experiments, independent control of coupling rates to different modes can lead to improved conversion…

Interactions between whispering gallery modes (WGMs) and small nanoparticles are commonly modelled by treating the particle as a point dipole scatterer. This approach is assumed to be accurate as long as the nanoparticle radius, $a$, is…

Designing high-finesse resonant cavities for electronic waves faces challenges due to short electron coherence lengths in solids. Previous approaches, e.g. the seminal nanometer-sized quantum corrals, depend on careful positioning of…

A review of hollow core whispering gallery resonators (WGRs)is given. After a short introduction to the topic of whispering gallery resonators we provide a description of whispering gallery modes in hollow or liquid core WGRs. Next,…

光学 · 物理学 2015-06-22 Jonathan M. Ward , Nitesh Dhasmana , Síle Nic Chormaic

Whispering gallery mode (WGM) microcavities feature ultrahigh Q-factors and small mode volumes, offering strong light-matter interactions for sensing applications. However, unmodified surfaces are weakly responsive togas-phase refractive…

Optical whispering gallery mode microcavity acoustic sensors have emerged significant potential in high-sensitivity acoustic signal detection, but the narrow dynamic range limits the application prospect. To address the challenge, we…

Mechanisms of whispering-gallery (WG) modes coupling in microdisk photonic molecules (PMs) with slight and significant size mismatch are numerically investigated. The results reveal two different scenarios of modes interaction depending on…

光学 · 物理学 2009-11-13 Svetlana V. Boriskina

Whispering gallery mode (WGM) microtoroid resonators are one of the most sensitive biochemical sensors in existence, capable of detecting single molecules. The main barrier for translating these devices out of the laboratory is that light…

光学 · 物理学 2024-03-18 Sartanee Suebka , Euan McLeod , Judith Su

Refractometric biosensing is a vital label-free tool for the real time detection and interaction analysis of biological and chemical substances. Nanophotonic platforms like Surface Plasmon Resonance (SPR) have played a critical role in…