相关论文: Monitoring Single DNA Docking Site Activity With S…
Nucleic acid sensing is crucial for advancing diagnostics, therapeutic monitoring and molecu-lar biology research, by enabling the precise identification of DNA and RNA interactions. Here, we present an innovative sensing platform based on…
Observing the hybridisation kinetics of DNA probes immobilised on plasmonic nanoparticles is key in plamon enhanced fluorescence detection from weak emitting species, and refractive index based single-molecule detection on optoplasmonic…
We report a comparison of two photonic techniques for single-molecule sensing: fluorescence nanoscopy and optoplasmonic sensing. As the test system, oligonucleotides with and without fluorescent labels are transiently hybridized to…
The whispering gallery modes (WGMs) of optical resonators have prompted intensive research efforts due to their usefulness in the field of biological sensing, and their employment in nonlinear optics. While much information is available in…
This work takes inspiration from chemistry where the spectral characteristics of the molecules are determined by hybridization of electronic states evolving from the individual atomic orbitals. Based on analogy between quantum mechanics and…
We investigate the possibility of using dielectric microdisk resonators for the optical detection of single atoms trapped and cooled in magnetic microtraps near the surface of a substrate. The bound and evanescent fields of optical…
Accurate, label-free quantification of multiple analytes in complex biological media remains a major challenge due to limited multiplexing, signal cross-correlations, and inconsistency across sensor samples and measurement runs. We…
Microcavity and whispering gallery mode (WGM) biosensors derive their sensitivity from monitoring frequency shifts induced by protein binding at sites of highly confined field intensities, where field strengths can be further amplified by…
Discerning the neurotransmitter dysregulation is a hallmark of neurological disorders and diseases, including Alzheimer's, Parkinson's, and multiple sclerosis. The concentration of neurotransmitters in the synaptic cleft is particularly…
Whispering gallery mode biosensors allow selective unlabelled detection of single proteins and, combined with quantum limited sensitivity, the possibility for noninvasive realtime observation of motor molecule motion. However, to date…
Whispering gallery mode (WGM) resonators are garnering significant attention due to their unique characteristics and remarkable properties. When integrated with optical sensing and processing technology, WGM resonators offer numerous…
Whispering-gallery mode resonators host multiple trapped narrowband circulating optical resonances that find applications in quantum electrodynamics, optomechanics, and sensing. However, the spherical symmetry and low field leakage of…
Sensors based on whispering gallery mode resonators can detect single nanoparticles and even single molecules. Particles attaching to the resonator induce a doublet in the transmission spectrum which provides a self-referenced detection…
Recently optical whispering-gallery-mode resonators (WGMRs) have emerged as promising platforms to achieve label-free detection of nanoscale objects and to reach single molecule sensitivity. The ultimate detection performance of WGMRs are…
Biosensing based on whispering-gallery mode (WGM) resonators has been continuously studied with great attention due to its excellent sensitivity guaranteeing the label-free detection. However, its practical impact is insignificant to date…
There are some issues with traditional whispering gallery mode (WGM) resonators like poor light extraction and a dense mode spectrum. In this paper we introduce a solution to these limitations by proposing open WGM (OWGM) resonators that…
Surface-enhanced Raman spectroscopy (SERS) sensing of DNA sequences by plasmonic nanopores could pave a way to new generation single-molecule sequencing platforms. The SERS discrimination of single DNA bases depends critically on the time…
We report on an experimental study of laser regime in erbium-doped whispering gallery mode (WGM) microspheres under modal-coupling between the co- and counter-propagating modes. The evidence of modal coupling has been observed in the…
Optical whispering gallery mode (WGM) microresonators, confining resonant photons in a microscale resonator for long periods of time, could strongly enhance light-matter interaction, making it an ideal platform for all kinds of sensors. In…
Biophotonics - and more recently, biointegrated photonics - offer transformative tools for probing cellular processes with unprecedented precision. Among these, whispering gallery mode (WGM) resonators - optical microcavities formed in…