相关论文: A Dopamine-Serotonin Theory of Consciousness

Serotonin (5-hydroxytryptamine) is a major neurotransmitter whose release from densely distributed serotonergic varicosities shapes plasticity and network integration throughout the brain, yet its extracellular dynamics remain poorly…

Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brainwide switching between activity states. The stability of…

As the world's first primary morbidity factor, depression has a considerable impact on both an individual as well as a societal level. despite their discovery several decades ago, classical antidepressants have been shown to provide limited…

This paper presents a hypothesis that consciousness is a natural result of neurons that become connected recursively, and work synchronously between short and long term memories. Such neurons demonstrate qubit-like properties, each…

Current theoretical and computational models of dopamine-based reinforcement learning are largely rooted in the classical behaviorist tradition, and envision the organism as a purely reactive recipient of rewards and punishments, with…

A quite general interaction process of a multi-component system is analysed by the extended effective potential method liberated from usual limitations of perturbation theory or integrable model. The obtained causally complete solution of…

Quantifying the neural signatures of consciousness remains a major challenge in neuroscience and AI. Although many theories link consciousness to rich, multiscale, and flexible neural organisation, robust quantitative measures are still…

The search for reliable indicators of consciousness has fragmented into competing theoretical camps (Global Workspace Theory (GWT), Integrated Information Theory (IIT), and Higher-Order Theories (HOT)), each proposing distinct neural…

In the field theories in physics, any particular region of the presumed space-time continuum and all interactions between elementary objects therein can be objectively measured and/or accounted for mathematically. Since this does not apply…

The mysterious phenomenon of consciousness, after having been the subject of philosophic attention for few millennia, has drawn much scientific curiosity in recent decades; and many brilliant minds of various areas of sciences are trying to…

The pursuit of artificial consciousness requires conceptual clarity to navigate its theoretical and empirical challenges. This paper introduces a composite, multilevel, and multidimensional model of consciousness as a heuristic framework to…

The science of consciousness has made great strides by focusing on the behavioral and neuronal correlates of experience. However, correlates are not enough if we are to understand even basic neurological fact; nor are they of much help in…

The problem of consciousness faced several challenges for a few reasons: (a) a lack of necessary and sufficient conditions, without which we would not know how close we are to the solution, (b) a lack of a synthesis framework to build…

Complex systems in the real world can be modeled as a network of connected components. The human brain, as a network of neurons among which the interactions cause perception, is a complex network. Synchronization is a dynamical phenomenon…

Major depressive disorder persistently stands as a major public health problem. While some progress has been made toward effective treatments, the neural mechanisms that give rise to the disorder remain poorly understood. In this…

Parkinson's Disease (PD) medication management presents unique challenges due to heterogeneous disease progression and treatment response. Neurologists must balance symptom control with optimal dopaminergic dosing based on functional…

The dynamic core hypothesis posits that consciousness is correlated with simultaneously integrated and differentiated assemblies of transiently synchronized brain regions. We represented time-dependent functional interactions using dynamic…

We have analysed the many facets of Consciousness into two distinct categories. First: the organisational state of the neural networks at any one time, which determines whether a person is conscious - awake, or unconscious - asleep. Second:…

We seek general principles of the structure of the cellular collective activity associated with conscious awareness. Can we obtain evidence for features of the optimal brain organization that allows for adequate processing of stimuli and…

We demonstrate that final-state uncertainty is ubiquitous in multistable systems of coupled neuronal maps, meaning that predicting whether one such system will eventually be chaotic or nonchaotic is often nearly impossible. We propose a…