相关论文: Antibody Foundational Model : Ab-RoBERTa

Large Language Models (LLM) continue to demonstrate their utility in a variety of emergent capabilities in different fields. An area that could benefit from effective language understanding in cybersecurity is the analysis of log files.…

Foundation models, first introduced in 2021, refer to large-scale pretrained models (e.g., large language models (LLMs) and vision-language models (VLMs)) that learn from extensive unlabeled datasets through unsupervised methods, enabling…

With the rise of Transformers and Large Language Models (LLMs) in Chemistry and Biology, new avenues for the design and understanding of therapeutics have opened up to the scientific community. Protein sequences can be modeled as language…

A pivotal area of research in antibody engineering is to find effective modifications that enhance antibody-antigen binding affinity. Traditional wet-lab experiments assess mutants in a costly and time-consuming manner. Emerging deep…

Recent advancements in large language models (LLMs) like ChatGPT and LLaMA show promise in medical applications, yet challenges remain in medical language comprehension. This study presents Me-LLaMA, a new medical LLM family based on…

We present ToddlerBERTa, a BabyBERTa-like language model, exploring its capabilities through five different models with varied hyperparameters. Evaluating on BLiMP, SuperGLUE, MSGS, and a Supplement benchmark from the BabyLM challenge, we…

Many applications need access to background knowledge about how different concepts and entities are related. Although Knowledge Graphs (KG) and Large Language Models (LLM) can address this need to some extent, KGs are inevitably incomplete…

Various parameter-efficient fine-tuning (PEFT) techniques have been proposed to enable computationally efficient fine-tuning while maintaining model performance. However, existing PEFT methods are still limited by the growing number of…

The accurate prediction of antigen-antibody structures is essential for advancing immunology and therapeutic development, as it helps elucidate molecular interactions that underlie immune responses. Despite recent progress with deep…

The release of open-weight large language models (LLMs) creates a tension between advancing accessible research and preventing misuse, such as malicious fine-tuning to elicit harmful content. Current safety measures struggle to preserve the…

Protein research is crucial in various fundamental disciplines, but understanding their intricate structure-function relationships remains challenging. Recent Large Language Models (LLMs) have made significant strides in comprehending…

Background: Identifying relationships between clinical events and temporal expressions is a key challenge in meaningfully analyzing clinical text for use in advanced AI applications. While previous studies exist, the state-of-the-art…

Antibodies are versatile proteins that can bind to pathogens and provide effective protection for human body. Recently, deep learning-based computational antibody design has attracted popular attention since it automatically mines the…

Large language models (LLMs) have shown remarkable advancements in chemistry and biomedical research, acting as versatile foundation models for various tasks. We introduce AMP-Designer, an LLM-based approach for swiftly designing novel…

Large-scale language models (LLMs) such as GPT-2, BERT and RoBERTa have been successfully applied to ASR N-best rescoring. However, whether or how they can benefit competitive, near state-of-the-art ASR systems remains unexplored. In this…

Antibodies safeguard our health through their precise and potent binding to specific antigens, demonstrating promising therapeutic efficacy in the treatment of numerous diseases, including COVID-19. Recent advancements in biomedical…

Pre-trained language models have been dominating the field of natural language processing in recent years, and have led to significant performance gains for various complex natural language tasks. One of the most prominent pre-trained…

Large language models (LLMs) have emerged as powerful tools for medical information retrieval, yet their accuracy and depth remain limited in specialized domains such as Alzheimer's disease (AD), a growing global health challenge. To…

Language model pretraining has led to significant performance gains but careful comparison between different approaches is challenging. Training is computationally expensive, often done on private datasets of different sizes, and, as we…

We propose a novel approach to enhancing the performance and efficiency of large language models (LLMs) by combining domain prompt routing with domain-specialized models. We introduce a system that utilizes a BERT-based router to direct…