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One way to quantify exposure to air pollution and its constituents in epidemiologic studies is to use an individual's nearest monitor. This strategy results in potential inaccuracy in the actual personal exposure, introducing bias in…

We present BayesPIM, a Bayesian prevalence-incidence mixture model for estimating time- and covariate-dependent disease incidence from screening and surveillance data. The method is particularly suited to settings where some individuals may…

统计方法学 · 统计学 2026-01-12 Thomas Klausch , Birgit I. Lissenberg-Witte , Veerle M. Coupé

Humans are exposed to complex mixtures of environmental pollutants rather than single chemicals, necessitating methods to quantify the health effects of such mixtures. Research on environmental mixtures provides insights into realistic…

统计方法学 · 统计学 2026-04-09 Aaron Sonabend , Jiangshan Zhang , Edgar Castro , Joel Schwartz , Brent A. Coull , Junwei Lu

An important issue in survival analysis is the investigation and the modeling of hazard rates. Within a Bayesian nonparametric framework, a natural and popular approach is to model hazard rates as kernel mixtures with respect to a…

统计理论 · 数学 2009-08-14 Pierpaolo De Blasi , Giovanni Peccati , Igor Prünster

Due to the growing adoption of deep neural networks in many fields of science and engineering, modeling and estimating their uncertainties has become of primary importance. Despite the growing literature about uncertainty quantification in…

机器学习 · 计算机科学 2023-02-15 Brian Staber , Sébastien Da Veiga

Estimating varying treatment effects in randomized trials with noncompliance is inherently challenging since variation comes from two separate sources: variation in the impact itself and variation in the compliance rate. In this setting,…

应用统计 · 统计学 2024-08-28 Jared D. Fisher , David W. Puelz , Sameer K. Deshpande

Maximum mean discrepancies (MMDs) like the kernel Stein discrepancy (KSD) have grown central to a wide range of applications, including hypothesis testing, sampler selection, distribution approximation, and variational inference. In each…

机器学习 · 统计学 2025-03-26 Alessandro Barp , Carl-Johann Simon-Gabriel , Mark Girolami , Lester Mackey

The nested error regression model is a useful tool for analyzing clustered (grouped) data, and is especially used in small area estimation. The classical nested error regression model assumes normality of random effects and error terms, and…

统计方法学 · 统计学 2016-05-16 Shonosuke Sugasawa , Tatsuya Kubokawa

We introduce the BMRMM package implementing Bayesian inference for a class of Markov renewal mixed models which can characterize the stochastic dynamics of a collection of sequences, each comprising alternative instances of categorical…

统计方法学 · 统计学 2024-09-18 Yutong Wu , Abhra Sarkar

The use of genetic variants as instrumental variables - an approach known as Mendelian randomization - is a popular epidemiological method for estimating the causal effect of an exposure (phenotype, biomarker, risk factor) on a disease or…

统计方法学 · 统计学 2020-12-21 Ioan Gabriel Bucur , Tom Claassen , Tom Heskes

Investigating the causal relationship between exposure and the time-to-event outcome is an important topic in biomedical research. Previous literature has discussed the potential issues of using the hazard ratio as a marginal causal effect…

统计方法学 · 统计学 2022-05-05 Zihan Lin , Ai Ni , Bo Lu

Kernel methods are one of the mainstays of machine learning, but the problem of kernel learning remains challenging, with only a few heuristics and very little theory. This is of particular importance in methods based on estimation of…

机器学习 · 统计学 2016-06-03 Seth Flaxman , Dino Sejdinovic , John P. Cunningham , Sarah Filippi

Mendelian randomization (MR) is a statistical method exploiting genetic variants as instrumental variables to estimate the causal effect of modifiable risk factors on an outcome of interest. Despite wide uses of various popular two-sample…

统计方法学 · 统计学 2021-11-17 Anqi Wang , Zhonghua Liu

Improving health worldwide will require rigorous quantification of population-level trends in health status. However, global-level surveys are not available, forcing researchers to rely on fragmentary country-specific data of varying…

统计方法学 · 统计学 2014-05-20 Mariel M. Finucane , Christopher J. Paciorek , Goodarz Danaei , Majid Ezzati

Multiple long-term conditions (MLTC) are increasingly observed in clinical practice globally. Clustering methods to group diseases into commonly co-occurring clusters have been of interest for further understanding of how MLTC group…

应用统计 · 统计学 2026-03-02 James Rafferty , Keith R Abrams , Munir Pirmohamed , Mark Davies , Rhiannon K Owen

This study develops a Bayesian hierarchical model to explore the effects of air pollution on respiratory and cardiovascular mortality in Los Angeles County. The model takes into account various pollutants such as PM2.5, PM10, CO, SO2, NO2…

应用统计 · 统计学 2025-01-29 Yanfei Qu , David A. Stephens

Estimation of the long-term health effects of air pollution is a challenging task, especially when modelling small-area disease incidence data in an ecological study design. The challenge comes from the unobserved underlying spatial…

统计方法学 · 统计学 2013-05-24 Duncan Lee , Alastair Rushworth , Sujit K. Sahu

The impact of wildfire smoke on air quality is a growing concern, contributing to air pollution through a complex mixture of chemical species with important implications for public health. While previous studies have primarily focused on…

统计方法学 · 统计学 2026-02-10 Dafne Zorzetto , Jenna Landy , Corwin Zigler , Giovanni Parmigiani , Roberta De Vito

In this study, a scalable online kernel learning framework is proposed for estimating bidirectional causal effects in systems characterized by mutual dependence and heteroskedasticity. Traditional causal inference often focuses on…

机器学习 · 统计学 2025-11-24 Masahiro Tanaka

Children's health studies support an association between maternal environmental exposures and children's birth outcomes. A common goal is to identify critical windows of susceptibility--periods during gestation with increased association…

统计方法学 · 统计学 2023-11-10 Daniel Mork , Marianthi-Anna Kioumourtzoglou , Marc Weisskopf , Brent A Coull , Ander Wilson