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Time-to-event data is widespread across the life sciences and engineering, but it is typically encountered together with censoring, which complicates the application of standard machine learning methods. Deep Cox models have emerged as a…

机器学习 · 统计学 2026-05-19 Anchit Jain , Kevin Zhang , Stephen Bates

The best known methods for estimating hazard rate functions in survival analysis models are either purely parametric or purely nonparametric. The parametric ones are sometimes too biased while the nonparametric ones are sometimes too…

统计方法学 · 统计学 2026-02-20 Nils Lid Hjort

Although treatment effects can be estimated from observed outcome distributions obtained from proper randomization in clinical trials, covariate adjustment is recommended to increase precision. For important treatment effects, such as odds…

统计方法学 · 统计学 2025-07-03 Susanne Dandl , Torsten Hothorn

This work explores the application of deep operator learning principles to a problem in statistical physics. Specifically, we consider the linear kinetic equation, consisting of a differential advection operator and an integral collision…

In survival analysis, Cox model is widely used for most clinical trial data. Alternatives include the additive hazard model, the accelerated failure time (AFT) model and a more general transformation model. All these models assume that the…

统计方法学 · 统计学 2016-03-24 Cheng Zheng , Ying Qing Chen

We consider a joint survival and mixed-effects model to explain the survival time from longitudinal data and high-dimensional covariates in a population. The longitudinal data is modeled using a non linear mixed-effects model to account for…

统计理论 · 数学 2025-08-06 Antoine Caillebotte , Estelle Kuhn , Sarah Lemler

A prevalent feature of high-dimensional data is the dependence among covariates, and model selection is known to be challenging when covariates are highly correlated. To perform model selection for the high-dimensional Cox proportional…

统计方法学 · 统计学 2022-10-04 Pierre Bayle , Jianqing Fan

In biomedical studies, we are often interested in the association between different types of covariates and the times to disease events. Because the relationship between the covariates and event times is often complex, standard survival…

统计方法学 · 统计学 2024-01-19 Hoi Min Ng , Kin Yau Wong

Models for predicting the time of a future event are crucial for risk assessment, across a diverse range of applications. Existing time-to-event (survival) models have focused primarily on preserving pairwise ordering of estimated event…

机器学习 · 统计学 2021-01-14 Paidamoyo Chapfuwa , Chenyang Tao , Lawrence Carin , Ricardo Henao

We study inference for censored survival data where some covariates are distorted by some unknown functions of an observable confounding variable in a multiplicative form. Example of this kind of data in medical studies is the common…

统计方法学 · 统计学 2020-06-03 Yanyan Liu , Yuanshan Wu , Jing Zhang , Haibo Zhou

Frailty models are often the model of choice for heterogeneous survival data. A frailty model contains both random effects and fixed effects, with the random effects accommodating for the correlation in the data. Different estimation…

统计方法学 · 统计学 2019-09-17 Oodally Ajmal , Luc Duchateau , Estelle Kuhn

Accurate prediction of disease trajectories is critical for early identification and timely treatment of patients at risk. Conventional methods in survival analysis are often constrained by strong parametric assumptions and limited in their…

机器学习 · 计算机科学 2018-11-28 Daniel Jarrett , Jinsung Yoon , Mihaela van der Schaar

Neural network based data-driven operator learning schemes have shown tremendous potential in computational mechanics. DeepONet is one such neural network architecture which has gained widespread appreciation owing to its excellent…

机器学习 · 统计学 2022-06-14 Shailesh Garg , Souvik Chakraborty

Aalen's linear hazard rate regression model is a useful and increasingly popular alternative to Cox' multiplicative hazard rate model. It postulates that an individual has hazard rate function $h(s)=z_1\alpha_1(s)+\cdots+z_r\alpha_r(s)$ in…

统计方法学 · 统计学 2026-03-04 Nils Lid Hjort , Emil Aas Stoltenberg

Competing risk data appear widely in modern biomedical research. Cause-specific hazard models are often used to deal with competing risk data in the past two decades. There is no current study on the kernel likelihood method for the…

统计方法学 · 统计学 2021-09-14 Xiaomeng Qi , Zhangsheng Yu

Time-dependent reliability analysis of nonlinear dynamical systems under stochastic excitations is a critical yet computationally demanding task. Conventional approaches, such as Monte Carlo simulation, necessitate repeated evaluations of…

机器学习 · 统计学 2026-03-24 Shailesh Garg , Souvik Chakraborty

The proportional hazards assumption in the commonly used Cox model for censored failure time data is often violated in scientific studies. Yang and Prentice (2005) proposed a novel semiparametric two-sample model that includes the…

统计方法学 · 统计学 2012-06-06 Guoqing Diao , Donglin Zeng , Song Yang

Balanced representation learning methods have been applied successfully to counterfactual inference from observational data. However, approaches that account for survival outcomes are relatively limited. Survival data are frequently…

In this note we explore a fully unsupervised deep-learning framework for simulating non-linear structural equation models from observational training data. The main contribution of this note is an architecture for applying moment-matching…

机器学习 · 统计学 2020-07-28 Michael Park

Single-index models or time-to-event models are frequently applied in empirical research. These models are non-identifiable in presence of unknown (dependent) censoring or competing risks and do not give informative results in empirical…

统计方法学 · 统计学 2026-03-25 Jia-Han Shih , Simon M. S. Lo , Ralf A. Wilke