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What role does phenotypic complexity play in the systems-level function of an embodied agent? The organismal phenotype is a topologically complex structure that interacts with a genotype, developmental physics, and an informational…

神经元与认知 · 定量生物学 2022-08-15 Bradly Alicea , Jesse Parent

Our understanding of the structure of the brain and its relationships with human traits is largely determined by how we represent the structural connectome. Standard practice divides the brain into regions of interest (ROIs) and represents…

应用统计 · 统计学 2023-06-13 Rongjie Liu , Meng Li , David B. Dunson

Finding an appropriate representation of dynamic activities in the brain is crucial for many downstream applications. Due to its highly dynamic nature, temporally averaged fMRI (functional magnetic resonance imaging) can only provide a…

机器学习 · 计算机科学 2022-08-18 Sikun Lin , Shuyun Tang , Scott Grafton , Ambuj Singh

Diffusion Magnetic Resonance Imaging (MRI) exploits the anisotropic diffusion of water molecules in the brain to enable the estimation of the brain's anatomical fiber tracts at a relatively high resolution. In particular, tractographic…

计算工程、金融与科学 · 计算机科学 2016-09-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

In neuroscience, researchers seek to uncover the connectivity of neurons from large-scale neural recordings or imaging; often people employ graphical model selection and estimation techniques for this purpose. But, existing technologies can…

机器学习 · 统计学 2021-04-14 Minjie Wang , Genevera I. Allen

Rule-based explanation methods offer rigorous and globally interpretable insights into neural network behavior. However, existing approaches are mostly limited to small fully connected networks and depend on costly layerwise rule extraction…

机器学习 · 计算机科学 2025-10-16 Chuqin Geng , Anqi Xing , Li Zhang , Ziyu Zhao , Yuhe Jiang , Xujie Si

Brain networks exhibit remarkable structural properties, including high local clustering, short path lengths, and heavy-tailed weight and degree distributions. While these features are thought to enable efficient information processing with…

生物物理 · 物理学 2026-01-09 Aitor Morales-Gregorio , Anno C. Kurth , Karolína Korvasová

With recent advancements in non-invasive techniques for measuring brain activity, such as magnetic resonance imaging (MRI), the study of structural and functional brain networks through graph signal processing (GSP) has gained notable…

机器学习 · 计算机科学 2025-11-13 Martín Schmidt , Sara Silva , Federico Larroca , Gonzalo Mateos , Pablo Musé

Brain network is an important tool for understanding the brain, offering insights for scientific research and clinical diagnosis. Existing models for brain networks typically primarily focus on brain regions or overlook the complexity of…

神经元与认知 · 定量生物学 2024-05-30 Haoyu Hu , Hongrun Zhang , Chao Li

Cognitive function is driven by dynamic interactions between large-scale neural circuits or networks, enabling behavior. Fundamental principles constraining these dynamic network processes have remained elusive. Here we use network control…

神经元与认知 · 定量生物学 2015-10-28 Shi Gu , Fabio Pasqualetti , Matthew Cieslak , Scott T. Grafton , Danielle S. Bassett

The brain's functional connectivity fluctuates over time instead of remaining steady in a stationary mode even during the resting state. This fluctuation establishes the dynamical functional connectivity that transitions in a non-random…

神经元与认知 · 定量生物学 2022-03-28 Shikuang Deng , Jingwei Li , B. T. Thomas Yeo , Shi Gu

Nanowire networks are promising memristive architectures for neuromorphic applications due to their connectivity and neurosynaptic-like behaviours. Here, we demonstrate a self-similar scaling of the conductance of networks and the junctions…

Recently, it has become progressively more evident that classic diagnostic labels are unable to reliably describe the complexity and variability of several clinical phenotypes. This is particularly true for a broad range of neuropsychiatric…

机器学习 · 计算机科学 2024-02-28 Giovanna Maria Dimitri , Simeon Spasov , Andrea Duggento , Luca Passamonti , Pietro Li`o , Nicola Toschi

In recent years, new and important perspectives were introduced in the field of neuroimaging with the emergence of the connectionist approach. In this new context, it is important to know not only which brain areas are activated by a…

神经元与认知 · 定量生物学 2019-04-17 Jean Faber , Priscila C. Antoneli , Guillem Via , Noemi S. Araújo , Daniel J. L. L. Pinheiro , Esper Cavalheiro

Neural networks are often described as black boxes, reflecting the significant challenge of understanding their internal workings and interactions. We propose a different perspective that challenges the prevailing view: rather than being…

机器学习 · 计算机科学 2025-10-23 Shuchen Wu , Stephan Alaniz , Shyamgopal Karthik , Peter Dayan , Eric Schulz , Zeynep Akata

What types of numeric representations emerge in neural systems, and what would a satisfying answer to this question look like? In this work, we interpret Neural Network (NN) solutions to sequence based number tasks using a variety of…

机器学习 · 计算机科学 2025-08-19 Satchel Grant , Noah D. Goodman , James L. McClelland

The brain can be regarded as a network: a connected system where nodes, or units, represent different specialized regions and links, or connections, represent communication pathways. From a functional perspective communication is coded by…

神经元与认知 · 定量生物学 2014-09-10 Fabrizio De Vico Fallani , Jonas Richiardi , Mario Chavez , Sophie Achard

Brain function and connectivity is a pressing mystery in medicine related to many diseases. Neural connectomes have been studied as graphs with graph theory methods including topological methods. Work has started on hypergraph models and…

统计方法学 · 统计学 2022-05-09 Michael G. Rawson

Studies of the dynamics of nonlinear recurrent neural networks often assume independent and identically distributed couplings, but large-scale connectomics data indicate that biological neural circuits exhibit markedly different…

神经元与认知 · 定量生物学 2025-10-28 David G. Clark , Owen Marschall , Alexander van Meegen , Ashok Litwin-Kumar

Dynamic networks have been increasingly used to characterize brain connectivity that varies during resting and task states. In such characterizations, a connectivity network is typically measured at each time point for a subject over a…

统计方法学 · 统计学 2023-03-23 Maoyu Zhang , Biao Cai , Wenlin Dai , Dehan Kong , Hongyu Zhao , Jingfei Zhang