相关论文: Information bounds on the accuracy of cell polariz…
Gradient sensing requires at least two measurements at different points in space. These measurements must then be communicated to a common location to be compared, which is unavoidably noisy. While much is known about the limits of…
Cell polarity and movement are fundamental to many biological functions. Experimental and theoretically studies have indicated that interactions of certain proteins lead to the cell polarization which plays a key role in controlling the…
We study the information loss of a class of inference strategies that is solely based on time averaging. For an array of independent binary sensors (e.g., receptors, single electron transistors) measuring a weak random signal (e.g., ligand…
A central challenge in cellular signal processing is understanding how biochemical networks perform reliably despite molecular noise. Traditionally, mutual information has been widely used to quantify signaling fidelity, capturing how well…
We present a novel approach to model ultrafast time-dependent nonlinear optical polarization sensitive signals emitted from randomly-oriented molecules. By projecting the laboratory-frame analyzer polarization axis into the molecular frame…
Biological cells estimate concentration gradients of signaling molecules with a precision that is limited not only by sensing noise, but additionally by the cell's own stochastic motion. We ask for the theoretical limits of gradient…
High precision polarization measurements open new opportunities for the study of the magnetic field structure as traced by polarimetric measurements of the interstellar dust emission. Polarization parameters suffer from bias in the presence…
Polarization optical fiber sensors are based on modifications of fiber birefringence by an external measurand (e.g. strain, pressure, acoustic waves). Yet, this means that different input states of polarization will result in very distinct…
Computing polarised intensities from noisy data in Stokes U and Q suffers from a positive bias that should be suppressed. To develop a correction method that, when applied to maps, should provide a distribution of polarised intensity that…
Cells must continuously sense and respond to time-varying environmental stimuli. These signals are transmitted and processed by biochemical signalling networks. However, the biochemical reactions making up these networks are intrinsically…
In recent years experiments have demonstrated that living cells can measure low chemical concentrations with high precision, and much progress has been made in understanding what sets the fundamental limit to the precision of chemical…
Recently, the information-theoretical framework has been proven to be able to obtain non-vacuous generalization bounds for large models trained by Stochastic Gradient Langevin Dynamics (SGLD) with isotropic noise. In this paper, we optimize…
Exploiting the information provided by the molecular noise of a biological process has proven to be valuable in extracting knowledge about the underlying kinetic parameters and sources of variability from single cell measurements. However,…
We propose a gradient-based framework for optimizing parametric nonlinear Gaussian channels via mutual information maximization. Leveraging the score-to-Fisher bridge (SFB) methodology, we derive a computationally tractable formula for the…
The achievable rate of information transfer in optical communications is determined by the physical properties of the communication channel, such as the intrinsic channel noise. Bosonic phase-noise channels, a class of non-Gaussian…
Cued and un-cued cell polarization is a fundamental mechanism in cell biology. As an alternative to the classical Turing bifurcation, it has been proposed that the cell polarity might onset by means of the well-known phenomenon of…
Data analysis in modern science using extensive experimental and observational facilities, such as a gravitational wave detector, is essential in the search for novel scientific discoveries. Accordingly, various techniques and mathematical…
When it is polarised, a cell develops an asymmetric distribution of specific molecular markers, cytoskeleton and cell membrane shape. Polarisation can occur spontaneously or be triggered by external signals, like gradients of signalling…
Ordered polarity alignment of a cell population plays a vital role in biology, such as in hair follicle alignment and asymmetric cell division. Here, we propose a theoretical framework for the understanding of generic dynamical properties…
Cells measure concentrations of external ligands by capturing ligand molecules with cell surface receptors. The numbers of molecules captured by different receptors co-vary because they depend on the same extrinsic ligand fluctuations.…