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Recent advances in biological research have seen the emergence of high-throughput technologies with numerous applications that allow the study of biological mechanisms at an unprecedented depth and scale. A large amount of genomic data is…

机器学习 · 统计学 2020-05-11 Nanwei Wang , Laurent Briollais , Helene Massam

Multilayer Perceptrons (MLPs) have long been a cornerstone in deep learning, known for their capacity to model complex relationships. Recently, Kolmogorov-Arnold Networks (KANs) have emerged as a compelling alternative, utilizing highly…

机器学习 · 计算机科学 2024-09-17 Farhad Pourkamali-Anaraki

Deep learning neural networks architectures such Multi Layer Perceptrons (MLP) and Convolutional blocks still play a crucial role in nowadays research advancements. From a topological point of view, these architecture may be represented as…

机器学习 · 计算机科学 2025-07-29 Ugo Lomoio , Pierangelo Veltri , Pietro Hiram Guzzi

Recent advancements in both representation learning and function learning have demonstrated substantial promise across diverse domains of artificial intelligence. However, the effective integration of these paradigms poses a significant…

机器学习 · 计算机科学 2024-10-07 Yunhong He , Yifeng Xie , Zhengqing Yuan , Lichao Sun

Kolmogorov-Arnold Networks (KANs) uniquely combine high accuracy with interpretability, making them valuable for scientific modeling. However, it is unclear a priori how deep a network needs to be for any given task, and deeper KANs can be…

机器学习 · 计算机科学 2025-08-22 James Bagrow , Josh Bongard

Prostate cancer is one of the most common causes of cancer deaths in men. There is a growing demand for noninvasively and accurately diagnostic methods that facilitate the current standard prostate cancer risk assessment in clinical…

图像与视频处理 · 电气工程与系统科学 2021-12-30 Ping-Chang Lin , Teodora Szasz , Hakizumwami B. Runesha

Domain experts often rely on most recent knowledge for apprehending and disseminating specific biological processes that help them design strategies for developing prevention and therapeutic decision-making in various disease scenarios. A…

Despite the unprecedented performance of deep neural networks (DNNs) in computer vision, their practical application in the diagnosis and prognosis of cancer using medical imaging has been limited. One of the critical challenges for…

机器学习 · 计算机科学 2023-04-27 Lennart Brocki , Neo Christopher Chung

The increasing quantity of multi-omics data, such as methylomic and transcriptomic profiles, collected on the same specimen, or even on the same cell, provide a unique opportunity to explore the complex interactions that define cell…

Omics data, such as transcriptomics, proteomics, and metabolomics, provide critical insights into disease mechanisms and clinical outcomes. However, their high dimensionality, small sample sizes, and intricate biological networks pose major…

机器学习 · 计算机科学 2026-01-22 Tiantian Yang , Yuxuan Wang , Zhenwei Zhou , Ching-Ti Liu

In healthcare, it is essential to explain the decision-making process of machine learning models to establish the trustworthiness of clinicians. This paper introduces BI-RADS-Net, a novel explainable deep learning approach for cancer…

计算机视觉与模式识别 · 计算机科学 2021-10-11 Boyu Zhang , Aleksandar Vakanski , Min Xian

Graphical model estimation from multi-omics data requires a balance between statistical estimation performance and computational scalability. We introduce a novel pseudolikelihood-based graphical model framework that reparameterizes the…

机器学习 · 统计学 2025-09-23 Sungdong Lee , Joshua Bang , Youngrae Kim , Hyungwon Choi , Sang-Yun Oh , Joong-Ho Won

With the increased affordability and availability of whole-genome sequencing, large-scale and high-throughput gene expression is widely used to characterize diseases, including cancers. However, establishing specificity in cancer diagnosis…

机器学习 · 统计学 2018-12-21 Xi Chen , Jin Xie , Qingcong Yuan

The Convolutional Neural Networks (CNNs) have been the dominant and effective approach for general computer vision tasks. Recently, Kolmogorov-Arnold neural networks (KANs), based on the Kolmogorov-Arnold representation theorem, have shown…

计算机视觉与模式识别 · 计算机科学 2026-04-28 Zhaoxiang Liu , Zhicheng Ma , Kaikai Zhao , Kai Wang , Shiguo Lian

Gene expression analysis is a critical method for cancer classification, enabling precise diagnoses through the identification of unique molecular signatures associated with various tumors. Identifying cancer-specific genes from gene…

Developing interpretable models for neurodevelopmental disorders (NDDs) diagnosis presents significant challenges in effectively encoding, decoding, and integrating multimodal neuroimaging data. While many existing machine learning…

计算机视觉与模式识别 · 计算机科学 2026-04-24 Yueyang Li , Lei Chen , Wenhao Dong , Shengyu Gong , Zijian Kang , Boyang Wei , Weiming Zeng , Hongjie Yan , Lingbin Bian , Zhiguo Zhang , Wai Ting Siok , Nizhuan Wang

While most modern machine learning methods offer speed and accuracy, few promise interpretability or explainability -- two key features necessary for highly sensitive industries, like medicine, finance, and engineering. Using eight datasets…

机器学习 · 计算机科学 2025-04-08 Nataly R. Panczyk , Omer F. Erdem , Majdi I. Radaideh

Multi-Layer Perceptrons (MLPs) rely on pre-defined, fixed activation functions, imposing a static inductive bias that forces the network to approximate complex topologies solely through increased depth and width. Kolmogorov-Arnold Networks…

The recently proposed Kolmogorov-Arnold network (KAN) is a promising alternative to multi-layer perceptrons (MLPs) for data-driven modeling. While original KAN layers were only capable of representing the addition operator, the…

机器学习 · 计算机科学 2025-07-28 Benjamin C. Koenig , Suyong Kim , Sili Deng

We propose DeepMiner, a framework to discover interpretable representations in deep neural networks and to build explanations for medical predictions. By probing convolutional neural networks (CNNs) trained to classify cancer in mammograms,…

计算机视觉与模式识别 · 计算机科学 2021-11-02 Jimmy Wu , Bolei Zhou , Diondra Peck , Scott Hsieh , Vandana Dialani , Lester Mackey , Genevieve Patterson