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We derive the statistics of the signals generated by shape fluctuations of large molecules studied by feedback tracking microscopy. We account for the influence of intramolecular dynamics on the response of the tracking system, and derive a…

光学 · 物理学 2015-05-13 Kevin McHale , Hideo Mabuchi

Using force as a probe to map the folding landscapes of RNA molecules has become a reality thanks to major advances in single molecule pulling experiments. Although the unfolding pathways under tension are complicated to predict studies in…

生物物理 · 物理学 2018-03-14 Changbong Hyeon , D. Thirumalai

Non-adiabatic molecular dynamics (NAMD) has become an essential computational technique for studying the photophysical relaxation of molecular systems after light absorption. These phenomena require approximations that go beyond the…

Glioblastoma, a highly aggressive primary brain tumor, is associated with poor patient outcomes. Although magnetic resonance imaging (MRI) plays a critical role in diagnosing, characterizing, and forecasting glioblastoma progression, public…

High-throughput screening using cell images is an efficient method for screening new candidates for pharmaceutical drugs. To complete the screening process, it is essential to have an efficient process for analyzing cell images. This paper…

计算机视觉与模式识别 · 计算机科学 2024-02-28 Mizuki Fukasawa , Tomokazu Fukuda , Takuya Akashi

Finding, identifying and segmenting suspicious cancer metastasized lymph nodes from 3D multi-modality imaging is a clinical task of paramount importance. In radiotherapy, they are referred to as Lymph Node Gross Tumor Volume (GTVLN).…

图像与视频处理 · 电气工程与系统科学 2020-08-28 Zhuotun Zhu , Dakai Jin , Ke Yan , Tsung-Ying Ho , Xianghua Ye , Dazhou Guo , Chun-Hung Chao , Jing Xiao , Alan Yuille , Le Lu

Molecular Dynamics (MD) simulation is a powerful tool for understanding the dynamics and structure of matter. Since the resolution of MD is atomic-scale, achieving long time-scale simulations with femtosecond integration is very expensive.…

机器学习 · 计算机科学 2022-04-27 Zijie Li , Kazem Meidani , Prakarsh Yadav , Amir Barati Farimani

Polymorphs in molecular crystals are often very close in energy, yet they may possess markedly different physical and chemical properties. The understanding and prediction of polymorphism is of paramount importance for a variety of…

Radiofrequency magnetic cycles of \textit{ex vivo} melanoma tumor tissue loaded with Fe$_3$O$_4$ nanoflowers (NF) were measured for several field conditions and compared with the cycles of a ferrogel (FG) obtained incorporating identical NF…

介观与纳米尺度物理 · 物理学 2022-09-28 I. J. Bruvera , D. G. Actis , P. Soto , V. Blank , L. Roguin , M. B. Fernandez van Raap , P. Mendoza Zelis

Gliomas are primary brain tumors with a high invasive potential and infiltrative spread. Among them, glioblastoma multiforme (GBM) exhibits microvascular hyperplasia and pronounced necrosis triggered by hypoxia. Histological samples showing…

组织与器官 · 定量生物学 2025-11-04 Pawan Kumar , Jing Li , Christina Surulescu

$\Lambda$-doublet spectra of light diatomic radicals have high sensitivity to the possible variations of the fine structure constant alpha and electron-to-proton mass ratio beta. For molecules OH and CH sensitivity is further enhanced…

宇宙学与河外天体物理 · 物理学 2009-09-01 M. G. Kozlov

Lymph node metastasis (LNM) is a significant prognostic factor in patients with head and neck cancer, and the ability to predict it accurately is essential for treatment optimization. PET and CT imaging are routinely used for LNM…

In this study, a radiomics approach was extended to optical fluorescence molecular imaging data for tissue classification, termed 'optomics'. Fluorescence molecular imaging is emerging for precise surgical guidance during head and neck…

Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as…

其他定量生物学 · 定量生物学 2012-02-21 Chi-Tin Shih , Stephen A. Wells , Ching-Ling Hsu , Yun-Yin Cheng , Rudolf A. Römer

Objective: To report imaging protocol and scheduling variance in routine care of glioblastoma patients in order to demonstrate challenges of integrating deep-learning models in glioblastoma care pathways. Additionally, to understand the…

One of the great challenges in biology is to observe, at sufficient detail, the real-time workings of the cell. Many methods exist to do cell measurements invasively. For example, mass spectrometry has tremendous mass sensitivity but…

定量方法 · 定量生物学 2017-10-23 Jan G. Korvink , Neil MacKinnon

Background: This research aims to improve glioblastoma survival prediction by integrating MR images, clinical and molecular-pathologic data in a transformer-based deep learning model, addressing data heterogeneity and performance…

A novel bio-photonics approach based on the nonlinear optical process of second harmonic generation by non-centrosymmetric nanoparticles is presented and demonstrated on malignant human cell lines. The proposed method allows to directly…

Glioblastoma is among the most aggressive brain tumors in adults, characterized by patient-specific invasion patterns driven by the underlying brain microstructure. In this work, we present a proof-of-concept for a mathematical model of GBL…

图像与视频处理 · 电气工程与系统科学 2025-06-23 D. Cerrone , D. Riccobelli , S. Gazzoni , P. Vitullo , F. Ballarin , J. Falco , F. Acerbi , A. Manzoni , P. Zunino , P. Ciarletta

We determine how a system composed of two nonidentical two-level atoms with different resonance frequencies and different damping rates could work as a nano-antenna for controlled mode switching and light routing. We calculate the angular…

量子物理 · 物理学 2015-06-17 Vassilis E. Lembessis , Anwar Al Rsheed , Omar M. Aldossary , Zbigniew Ficek