相关论文: Quantifying Circadian Desynchrony in ICU Patients …

Early mobilization of critically ill patients in the Intensive Care Unit (ICU) can prevent adverse outcomes such as delirium and post-discharge physical impairment. To date, no studies have characterized activity of sepsis patients in the…

Despite the importance of closely monitoring patients in the Intensive Care Unit (ICU), many aspects are still assessed in a limited manner due to the time constraints imposed on healthcare providers. For example, although excessive…

Circadian rhythms are biological rhythms of approximately 24 h that persist even under constant conditions without environmental daily cues. The molecular circadian clock machinery generates the physiological rhythms, which can be…

Objective: The circadian rhythm synchronizes physiological and behavioural patterns with the 24-hour light-dark cycle. Disruption to the circadian rhythm is linked to various health conditions, though optimal methods to describe these…

Existing Intensive Care Unit (ICU) delirium prediction models do not consider environmental factors despite strong evidence of their influence on delirium. This study reports the first deep-learning based delirium prediction model for ICU…

A biophysical model of arousal dynamics is used to study mechanisms of synchronisation and loss of synchrony among the three key oscillators controlling sleep-wake cycles: the circadian, homeostatic, and light oscillators. Synchronisation…

Purpose: Summarize ICU delirium prediction models published within the past five years. Methods: Electronic searches were conducted in April 2019 using PubMed, Embase, Cochrane Central, Web of Science, and CINAHL to identify peer reviewed…

Acute brain dysfunction (ABD) is a common, severe ICU complication, presenting as delirium or coma and leading to prolonged stays, increased mortality, and cognitive decline. Traditional screening tools like the Glasgow Coma Scale (GCS),…

Delirium, an acute confusional state, is a common occurrence in Intensive Care Units (ICUs). Patients who develop delirium have globally worse outcomes than those who do not and thus the diagnosis of delirium is of importance. Current…

Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain. Here, we use the…

It has recently been observed that the occurrence of sudden cardiac death has a close statistical relationship with the time of day, viz., ventricular fibrillation is most likely to occur between 12 am-6 am, with 6 pm-12 am being the next…

Circadian rhythms govern biological patterns that follow a 24-hour cycle. Dysfunctions in circadian rhythms can contribute to various health problems, such as sleep disorders. Current circadian rhythm assessment methods, often invasive or…

Circadian rhythm is the natural biological cycle manifested in human daily routines. A regular and stable rhythm is found to be correlated with good physical and mental health. With the wide adoption of mobile and wearable technology, many…

The mammalian circadian system comprises a network of cell-autonomous oscillators, spanning from the central clock in the brain to peripheral clocks in other organs. These clocks are tightly coordinated to orchestrate rhythmic physiological…

This study reports the findings of qualitative interview sessions conducted with ICU clinicians for the co-design of a system user interface of an artificial intelligence (AI)-driven clinical decision support (CDS) system. This system…

Delirium occurs in about 80% cases in the Intensive Care Unit (ICU) and is associated with a longer hospital stay, increased mortality and other related issues. Delirium does not have any biomarker-based diagnosis and is commonly treated…

The circadian rhythm in the occurrence of acute myocardial infarction (AMI) was assessed in three hundred and twenty three patients admitted with AMI during the two-year period June 1992 to May 1994. The influence of the following…

Cardiac and respiratory rhythms are known to exhibit a modest degree of phase synchronization, which is affected by age, diseases, and other factors. We study the fine temporal structure of this synchrony in healthy young, healthy elderly,…

Diabetes cases worldwide have risen steadily over the past decades, lending urgency to the search for more efficient, effective, and personalized ways to treat the disease. Current treatment strategies, however, may fail to maintain…

In the United States, more than 5 million patients are admitted annually to ICUs, with ICU mortality of 10%-29% and costs over $82 billion. Acute brain dysfunction status, delirium, is often underdiagnosed or undervalued. This study's…