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Innate immunity now occupies a central role in immunology. However, artificial immune system models have largely been inspired by adaptive not innate immunity. This paper reviews the biological principles and properties of innate immunity…

人工智能 · 计算机科学 2010-07-05 Jamie Twycross , Uwe Aickelin

The robustness of any machine learning solution is fundamentally bound by the data it was trained on. One way to generalize beyond the original training is through human-informed augmentation of the original dataset; however, it is…

机器学习 · 计算机科学 2022-09-08 Nicholas A. Ketz , Praveen K. Pilly

Individual-based model (IBM) has been used to simulate and to design control strategies for dynamic systems that are subject to stochasticity and heterogeneity, such as infectious diseases. In the IBM, an individual is represented by a set…

种群与进化 · 定量生物学 2019-02-11 E. G. Nepomuceno , D. F. Resende , M. J. Lacerda

Despite the remarkable generation capabilities of diffusion models, recent studies have shown that they can memorize and create harmful content when given specific text prompts. Although fine-tuning approaches have been developed to…

计算机视觉与模式识别 · 计算机科学 2025-06-03 Siyi Chen , Yimeng Zhang , Sijia Liu , Qing Qu

Recent advances in generative models have demonstrated remarkable capabilities in producing high-quality images, but their reliance on large-scale unlabeled data has raised significant safety and copyright concerns. Efforts to address these…

计算机视觉与模式识别 · 计算机科学 2025-07-21 Yang Zhang , Er Jin , Yanfei Dong , Yixuan Wu , Philip Torr , Ashkan Khakzar , Johannes Stegmaier , Kenji Kawaguchi

Adapting general-purpose language models to new skills is currently an expensive process that must be repeated as new instruction datasets targeting new skills are created, or can cause the models to forget older skills. In this work, we…

计算与语言 · 计算机科学 2024-10-18 Jacob Morrison , Noah A. Smith , Hannaneh Hajishirzi , Pang Wei Koh , Jesse Dodge , Pradeep Dasigi

In the era of deep learning, the increasing number of pre-trained models available online presents a wealth of knowledge. These models, developed with diverse architectures and trained on varied datasets for different tasks, provide unique…

计算机视觉与模式识别 · 计算机科学 2025-08-28 Yimu Wang , Weiming Zhuang , Chen Chen , Jiabo Huang , Jingtao Li , Lingjuan Lyu

We consider scenarios where a very accurate (often small) predictive model using restricted features is available when training a full-featured (often larger) model. This restricted model may be thought of as side-information'', and can…

机器学习 · 计算机科学 2025-04-10 Usama Muneeb , Mesrob I. Ohannessian

In this review we make the statement that hybrid models in oncology are required as a mean for enhanced data integration. In the context of systems oncology, experimental and clinical data need to be at the heart of the models developments…

定量方法 · 定量生物学 2019-01-18 Angélique Stéphanou , Pascal Ballet , Gibin Powathil

In this article I describe a research agenda for securing machine learning models against adversarial inputs at test time. This article does not present results but instead shares some of my thoughts about where I think that the field needs…

机器学习 · 计算机科学 2019-03-18 Ian Goodfellow

Complex systems' modeling and simulation are powerful ways to investigate a multitude of natural phenomena providing extended knowledge on their structure and behavior. However, enhanced modeling and simulation require integration of…

This paper investigates the conceptual relationship between openness and reproducibility using a model-centric approach, heavily informed by probability theory and statistics. We first clarify the concepts of reliability, auditability,…

其他统计学 · 统计学 2019-10-30 Bert Baumgaertner , Berna Devezer , Erkan O. Buzbas , Luis G. Nardin

When studying the association between treatment and a clinical outcome, a parametric multivariable model of the conditional outcome expectation is often used to adjust for covariates. The treatment coefficient of the outcome model targets a…

统计方法学 · 统计学 2026-05-07 Antonio Remiro-Azócar , Anna Heath , Gianluca Baio

Transfer-learning and meta-learning are two effective methods to apply knowledge learned from large data sources to new tasks. In few-class, few-shot target task settings (i.e. when there are only a few classes and training examples…

机器学习 · 计算机科学 2019-02-11 Amir Erfan Eshratifar , Mohammad Saeed Abrishami , David Eigen , Massoud Pedram

Privacy data protection in the medical field poses challenges to data sharing, limiting the ability to integrate data across hospitals for training high-precision auxiliary diagnostic models. Traditional centralized training methods are…

计算机视觉与模式识别 · 计算机科学 2024-08-26 Tian Bowen , Xu Zhengyang , Yin Zhihao , Wang Jingying , Yue Yutao

Concept bottleneck models (CBMs), which predict human-interpretable concepts (e.g., nucleus shapes in cell images) before predicting the final output (e.g., cell type), provide insights into the decision-making processes of the model.…

计算机视觉与模式识别 · 计算机科学 2024-07-10 Winnie Pang , Xueyi Ke , Satoshi Tsutsui , Bihan Wen

This paper introduces Multi-Garment Customized Model Generation, a unified framework based on Latent Diffusion Models (LDMs) aimed at addressing the unexplored task of synthesizing images with free combinations of multiple pieces of…

计算机视觉与模式识别 · 计算机科学 2024-08-12 Yichen Liu , Penghui Du , Yi Liu Quanwei Zhang

With the recent wave of digitalization, specifically in the context of safety-critical applications, there has been a growing need for computationally efficient, accurate, generalizable, and trustworthy models. Physics-based models have…

数值分析 · 数学 2023-09-20 Sondre Sørbø , Sindre Stenen Blakseth , Adil Rasheed , Trond Kvamsdal , Omer San

We present a novel methodology for integrating high resolution longitudinal data with the dynamic prediction capabilities of survival models. The aim is two-fold: to improve the predictive power while maintaining interpretability of the…

应用统计 · 统计学 2024-03-07 Giacomo Lancia , Meri Varkila , Olaf Cremer , Cristian Spitoni

Model merging, which combines multiple domain-specialized experts into a single model, offers a practical path to endow Large Language Models (LLMs) and Multimodal Large Language Models (MLLMs) with broad capabilities without the cost of…

机器学习 · 计算机科学 2025-10-01 Dengming Zhang , Xiaowen Ma , Zhenliang Ni , Zhenkai Wu , Han Shu , Xin Jiang , Xinghao Chen