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Wastewater surveillance has proven to be a useful tool to monitor pathogens such as SARS-CoV-2 as it is a nonintrusive way to survey the potential disease burden of the population contributing to a sewershed. With the expansion of this…

In light of the continuous transmission and evolution of SARS-CoV-2 coupled with a significant decline in clinical testing, there is a pressing need for scalable, cost-effective, long-term, passive surveillance tools to effectively monitor…

Wastewater data can be very useful for epidemic control during a disease outbreak and proper synthesis of different sources of information can be integrated towards an alerting system, that can be used for decision support. Wastewater data…

In the case of SARS-CoV-2 pandemic management, wastewater-based epidemiology aims to derive information on the infection dynamics by monitoring virus concentrations in the wastewater. However, due to the intrinsic random fluctuations of the…

In the post-pandemic era of COVID-19, hospitalization remains a primary public health concern and wastewater surveillance has become an important tool for monitoring its dynamics at the level of community. However, there is usually no…

统计方法学 · 统计学 2026-01-14 K. Ken Peng , Charmaine B. Dean , Robert Delatolla , X. Joan Hu , Elizabeth Renouf

Individuals infected with SARS-CoV-2, the virus that causes COVID-19, may shed the virus in stool before developing symptoms, suggesting that measurements of SARS-CoV-2 concentrations in wastewater could be a "leading indicator" of COVID-19…

其他定量生物学 · 定量生物学 2021-06-25 Scott W. Olesen , Maxim Imakaev , Claire Duvallet

During an infectious disease outbreak, providing accurate answers to policy questions about transmission requires a detailed model of the natural history of infectiousness. Unfortunately, direct measures of infectiousness are generally…

Viral signal in wastewater offers a promising opportunity to assess and predict the burden of infectious diseases. That has driven the widespread adoption and development of wastewater monitoring tools by public health organizations. Recent…

统计方法学 · 统计学 2024-10-11 K. Ken Peng , Charmaine B. Dean , Robert Delatolla , X. Joan Hu

Concentrations of pathogen genomes measured in wastewater have recently become available as a new data source to use when modeling the spread of infectious diseases. One promising use for this data source is inference of the effective…

统计方法学 · 统计学 2024-06-24 Isaac H. Goldstein , Daniel M. Parker , Sunny Jiang , Volodymyr M. Minin

Wastewater based epidemiology is recognized as one of the monitoring pillars, providing essential information for pandemic management. Central in the methodology are data modelling concepts for both communicating the monitoring results but…

应用统计 · 统计学 2022-08-30 Wolfgang Rauch , Hannes Schenk , Heribert Insam , Rudolf Markt , Norbert Kreuzinger

Understanding the viral dynamics and immunizing antibodies of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for devising better therapeutic and prevention strategies for COVID-19. Here, we present a Bayesian…

应用统计 · 统计学 2023-07-27 Tracy Q. Dong , Elizabeth R. Brown

Despite the progress in medical data collection the actual burden of SARS-CoV-2 remains unknown due to under-ascertainment of cases. This was apparent in the acute phase of the pandemic and the use of reported deaths has been pointed out as…

应用统计 · 统计学 2023-07-13 Anastasia Chatzilena , Nikolaos Demiris , Konstantinos Kalogeropoulos

We consider the dynamics of a virus spreading through a population that produces a mutant strain with the ability to infect individuals that were infected with the established strain. Temporary cross-immunity is included using a time delay,…

种群与进化 · 定量生物学 2023-02-16 Bruce Pell , Samantha Brozak , Tin Phan , Fuqing Wu , Yang Kuang

With the global spread and increasing transmission rate of SARS-CoV-2, more and more laboratories and researchers are turning their attention to wastewater-based epidemiology (WBE), hoping it can become an effective tool for large-scale…

Wastewater surveillance has emerged as a critical public health tool, enabling early detection of infectious disease outbreaks and providing timely, population-level insights into community health trends. However, variability in sample…

Wastewater-based epidemiology (WBE) is an effective tool for tracking community circulation of respiratory viruses. We address estimating the effective reproduction number ($R_t$) and the relative number of infections from wastewater viral…

The pandemic of COVID-19 has imposed tremendous pressure on public health systems and social economic ecosystems over the past years. To alleviate its social impact, it is important to proactively track the prevalence of COVID-19 within…

A numerical framework for the 'real-time' estimation of the infection risk from airborne diseases (e.g., SARS-CoV-2) in indoor spaces such as hospitals, restaurants, cinemas or teaching rooms is proposed. The developed model is based on the…

A pipeline to evaluate the evolution of viral dynamics based on a new model-driven approach has been developed in the present study. The proposed methods exploit real data and the multiscale structure of the infection dynamics to provide…

Monitoring the incidence of new infections during a pandemic is critical for an effective public health response. General population prevalence surveys for SARS-CoV-2 can provide high-quality data to estimate incidence. However, estimation…

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