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Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by atypical brain connectivity. One of the crucial steps in addressing ASD is its early detection. This study introduces a novel computational framework that…

应用统计 · 统计学 2026-03-31 Abigail Kelly , Ramchandra Rimal , Arpan Sainju

Topological data analysis (TDA) has become a powerful approach over the last twenty years, mainly due to its ability to capture the shape and the geometry inherent in the data. Persistence homology, which is a particular tool in TDA, has…

神经元与认知 · 定量生物学 2024-01-12 Anass B. El-Yaagoubi , Shuhao Jiao , Moo K. Chung , Hernando Ombao

While the prevalence of Autism Spectrum Disorder (ASD) is increasing, research continues in an effort to identify common etiological and pathophysiological bases. In this regard, modern machine learning and network science pave the way for…

图像与视频处理 · 电气工程与系统科学 2020-08-06 Sarah Itani , Dorina Thanou

We propose a model for diagnosing Autism spectrum disorder (ASD) using multimodal magnetic resonance imaging (MRI) data. Our approach integrates brain connectivity data from diffusion tensor imaging (DTI) and functional MRI (fMRI),…

神经元与认知 · 定量生物学 2024-10-10 Lu Wei , Yi Huang , Guosheng Yin , Fode Zhang , Manxue Zhang , Bin Liu

The global functional brain network (graph) is more suitable for characterizing brain states than local analysis of the connectivity of brain regions. Therefore, graph-theoretic approaches are the natural methods to study the brain.…

统计方法学 · 统计学 2015-12-22 André Fujita , Daniel Yasumasa Takahashi , Joana Bisol Balardin , João Ricardo Sato

Over the last years, increasing evidence has fuelled the hypothesis that Autism Spectrum Disorder (ASD) is a condition of altered brain functional connectivity. The great majority of these empirical studies rely on functional magnetic…

神经元与认知 · 定量生物学 2010-08-02 Pablo Barttfeld , Bruno Wicker , Sebastián Cukier , Silvana Navarta , Sergio Lew , Mariano Sigman

Research in machine learning for autism spectrum disorder (ASD) classification bears the promise to improve clinical diagnoses. However, recent studies in clinical imaging have shown the limited generalization of biomarkers across and…

机器学习 · 计算机科学 2022-09-23 Christian Gerloff , Kerstin Konrad , Jana Kruppa , Martin Schulte-Rüther , Vanessa Reindl

Topological data analysis (TDA) is an emerging technique for biological signal processing. TDA leverages the invariant topological features of signals in a metric space for robust analysis of signals even in the presence of noise. In this…

代数拓扑 · 数学 2024-01-11 Shashank Manjunath , Jose A. Perea , Aarti Sathyanarayana

In this paper we utilized the concept of stable phase synchronization topography - synchrostates - over the scalp derived from EEG recording for formulating brain connectivity network in Autism Spectrum Disorder (ASD) and typically-growing…

Topological data analysis (TDA) approaches are becoming increasingly popular for studying the dependence patterns in multivariate time series data. In particular, various dependence patterns in brain networks may be linked to specific tasks…

统计方法学 · 统计学 2025-12-08 Anass El Yaagoubi Bourakna , Moo K. Chung , Hernando Ombao

Topological data analysis (TDA) approaches are becoming increasingly popular for studying the dependence patterns in multivariate time series data. In particular, various dependence patterns in brain networks may be linked to specific tasks…

统计方法学 · 统计学 2023-12-04 Anass B. El-Yaagoubi , Hernando Ombao

Autism spectrum disorder (ASD) is regarded as a brain disease with globally disrupted neuronal networks. Even though fMRI studies have revealed abnormal functional connectivity in ASD, they have not reached a consensus of the disrupted…

计算机视觉与模式识别 · 计算机科学 2017-07-26 Hongyoon Choi

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by varied social cognitive challenges and repetitive behavioral patterns. Identifying reliable brain imaging-based biomarkers for ASD has been a persistent…

Anatomical and functional brain studies have converged to the hypothesis that Autism Spectrum Disorders (ASD) are associated with atypical connectivity. Using a modified resting-state paradigm to drive subjects' attention, we provide…

神经元与认知 · 定量生物学 2012-11-21 Pablo Barttfeld , Bruno Wicker , Sebastián Cukier , Silvana Navarta , Sergio Lew , Ramón Leiguarda , Mariano Sigman

Autism Spectrum Disorder(ASD) is a set of neurodevelopmental conditions that affect patients' social abilities. In recent years, many studies have employed deep learning to diagnose this brain dysfunction through functional MRI (fMRI).…

图像与视频处理 · 电气工程与系统科学 2021-10-26 Li Pan , Jundong Liu , Mingqin Shi , Chi Wah Wong , Kei Hang Katie Chan

In this study, we proposed and evaluated a graph-based framework to assess variations in Alzheimer's disease (AD) neuropathologies, focusing on classic (cAD) and rapid (rpAD) progression forms. Histopathological images are converted into…

图像与视频处理 · 电气工程与系统科学 2024-07-08 Gabriel Jimenez , Leopold Hebert-Stevens , Benoit Delatour , Lev Stimmer , Daniel Racoceanu

Functional Magnetic Resonance Imaging (fMRI) is commonly utilized to study human brain activity, including abnormal functional properties related to neurodegenerative diseases. This study aims to investigate the differences in the…

神经元与认知 · 定量生物学 2023-05-17 Yongcheng Yao

Using predictive models to identify patterns that can act as biomarkers for different neuropathoglogical conditions is becoming highly prevalent. In this paper, we consider the problem of Autism Spectrum Disorder (ASD) classification where…

机器学习 · 统计学 2018-10-31 Rushil Anirudh , Jayaraman J. Thiagarajan

Developing reliable methods to discriminate different transient brain states that change over time is a key neuroscientific challenge in brain imaging studies. Topological data analysis (TDA), a novel framework based on algebraic topology,…

神经元与认知 · 定量生物学 2023-12-19 Moo K. Chung , Soumya Das , Hernando Ombao

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by atypical functional brain connectivity and subtle structural alterations. rs-fMRI has been widely used to identify disruptions in large-scale brain…

计算机视觉与模式识别 · 计算机科学 2026-03-17 Ansar Rahman , Hassan Shojaee-Mend , Sepideh Hatamikia
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