相关论文: scFusionTTT: Single-cell transcriptomics and prote…

Predicting drug-target interaction (DTI) is critical in the drug discovery process. Despite remarkable advances in recent DTI models through the integration of representations from diverse drug and target encoders, such models often…

Deep learning models have demonstrated exceptional performance across a wide range of computer vision tasks. However, their performance often degrades significantly when faced with distribution shifts, such as domain or dataset changes.…

Spatial transcriptomics (ST) technologies enable gene expression profiling with spatial resolution, offering unprecedented insights into tissue organization and disease heterogeneity. However, current analysis methods often struggle with…

Training on large-scale datasets can boost the performance of video instance segmentation while the annotated datasets for VIS are hard to scale up due to the high labor cost. What we possess are numerous isolated filed-specific datasets,…

Pathology foundation models learn morphological representations through self-supervised pretraining on large-scale whole-slide images, yet they do not explicitly capture the underlying molecular state of the tissue. Spatial transcriptomics…

Recently, there has been an increasing interest in end-to-end speech recognition that directly transcribes speech to text without any predefined alignments. One approach is the attention-based encoder-decoder framework that learns a mapping…

Accurate and scalable cell type annotation remains a challenge in single-cell transcriptomics, especially when datasets exhibit strong batch effects or contain previously unseen cell populations. Here we introduce SpikGPT, a hybrid deep…

Multimodal data arise in various applications where information about the same phenomenon is acquired from multiple sensors and across different imaging modalities. Learning from multimodal data is of great interest in machine learning and…

The spatial location of cells within tissues and organs is crucial for the manifestation of their specific functions.Spatial transcriptomics technology enables comprehensive measurement of the gene expression patterns in tissues while…

Melanoma is a malignant tumor that originates from skin cell lesions. Accurate and efficient segmentation of skin lesions is essential for quantitative analysis but remains a challenge due to blurred lesion boundaries, gradual color…

Finding effective representations for time series data is a useful but challenging task. Several works utilize self-supervised or unsupervised learning methods to address this. However, there still remains the open question of how to…

In this paper, we introduce a novel Synchronized Class Token Fusion (SCT Fusion) architecture in the framework of multi-modal multi-label classification (MLC) of remote sensing (RS) images. The proposed architecture leverages…

Motivation: Single cell transcriptome sequencing (scRNA-Seq) has become a revolutionary tool to study cellular and molecular processes at single cell resolution. Among existing technologies, the recently developed droplet-based platform…

Breast cancer screening, primarily conducted through mammography, is often supplemented with ultrasound for women with dense breast tissue. However, existing deep learning models analyze each modality independently, missing opportunities to…

In this paper, I introduce a Sequence-based Multiscale Model (SeqMM) for the biomolecular data analysis. With the combination of spectral graph method, I reveal the essential difference between the global scale models and local scale ones…

Automated histopathological image analysis plays a vital role in computer-aided diagnosis of various diseases. Among developed algorithms, deep learning-based approaches have demonstrated excellent performance in multiple tasks, including…

Cancer drug response varies widely across tumors due to multi-layer molecular heterogeneity, motivating computational decision support for precision oncology. Despite recent progress in deep CDR models, robust alignment between…

Background: Single-cell RNA sequencing (scRNA-seq) yields valuable insights about gene expression and gives critical information about complex tissue cellular composition. In the analysis of single-cell RNA sequencing, the annotations of…

Background and Objective: Given the high heterogeneity and clinical diversity of cancer, substantial variations exist in multi-omics data and clinical features across different cancer subtypes. Methods: We propose a model, named DEDUCE,…

With the increasing availability of diverse data types, particularly images and time series data from medical experiments, there is a growing demand for techniques designed to combine various modalities of data effectively. Our motivation…