相关论文: scFusionTTT: Single-cell transcriptomics and prote…

Multi-task learning (MTL) is a powerful approach in deep learning that leverages the information from multiple tasks during training to improve model performance. In medical imaging, MTL has shown great potential to solve various tasks.…

The rapid advancement of single-cell ATAC sequencing (scATAC-seq) technologies holds great promise for investigating the heterogeneity of epigenetic landscapes at the cellular level. The amplification process in scATAC-seq experiments often…

Supervised Causal Learning (SCL) has shown promise in causal discovery by framing it as a supervised learning problem. However, it suffers from significant out-of-distribution generalization challenges. We reveal three limitations of…

Test-time adaptation enables a trained model to adjust to a new domain during inference, making it particularly valuable in clinical settings where such on-the-fly adaptation is required. However, existing techniques depend on large target…

Functional MRI (fMRI) and single-cell transcriptomics are pivotal in Alzheimer's disease (AD) research, each providing unique insights into neural function and molecular mechanisms. However, integrating these complementary modalities…

Medical time series data are indispensable in healthcare, providing critical insights for disease diagnosis, treatment planning, and patient management. The exponential growth in data complexity, driven by advanced sensor technologies, has…

Self-supervised learning approaches provide a promising direction for clustering multivariate time-series data. However, real-world time-series data often include missing values, and the existing approaches require imputing missing values…

Early and accurate interpretation of screening mammograms is essential for effective breast cancer detection, yet it remains a complex challenge due to subtle imaging findings and diagnostic ambiguity. Many existing AI approaches fall short…

Generalizing neural networks to unseen target domains is a significant challenge in real-world deployments. Test-time training (TTT) addresses this by using an auxiliary self-supervised task to reduce the domain gap caused by distribution…

We present a novel approach for the prediction of anticancer compound sensitivity by means of multi-modal attention-based neural networks (PaccMann). In our approach, we integrate three key pillars of drug sensitivity, namely, the molecular…

Multimodal learning has been lacking principled ways of combining information from different modalities and learning a low-dimensional manifold of meaningful representations. We study multimodal learning and sensor fusion from a latent…

Spatial transcriptomics (ST) provides spatially resolved measurements of gene expression, enabling characterization of the molecular landscape of human tissue beyond histological assessment as well as localized readouts that can be aligned…

Image fusion aims to blend complementary information from multiple sensing modalities, yet existing approaches remain limited in robustness, adaptability, and controllability. Most current fusion networks are tailored to specific tasks and…

To acquire instruction-following capabilities, large language models (LLMs) undergo instruction tuning, where they are trained on instruction-response pairs using next-token prediction (NTP). Efforts to improve instruction tuning often…

Single-cell transcriptomics and proteomics have become a great source for data-driven insights into biology, enabling the use of advanced deep learning methods to understand cellular heterogeneity and gene expression at the single-cell…

Breast cancer is a leading cause of cancer-related mortality worldwide, and timely accurate diagnosis is critical to improving survival outcomes. While convolutional neural networks (CNNs) have demonstrated strong performance on…

Healthcare applications are inherently multimodal, benefiting greatly from the integration of diverse data sources. However, the modalities available in clinical settings can vary across different locations and patients. A key area that…

While pathology foundation models have transformed cancer image analysis, they often lack integration with molecular data at single-cell resolution, limiting their utility for precision oncology. Here, we present PAST, a pan-cancer…

Cancer is a highly heterogeneous disease with significant variability in molecular features and clinical outcomes, making diagnosis and treatment challenging. In recent years, high-throughput omic technologies have facilitated the discovery…

Learning efficient and expressive visual representation has long been the pursuit of computer vision research. While Vision Transformers (ViTs) gradually replace traditional Convolutional Neural Networks (CNNs) as more scalable vision…