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Digital pathology based on whole slide images (WSIs) plays a key role in cancer diagnosis and clinical practice. Due to the high resolution of the WSI and the unavailability of patch-level annotations, WSI classification is usually…

计算机视觉与模式识别 · 计算机科学 2023-05-02 Litao Yang , Deval Mehta , Sidong Liu , Dwarikanath Mahapatra , Antonio Di Ieva , Zongyuan Ge

Kernel survival analysis models estimate individual survival distributions with the help of a kernel function, which measures the similarity between any two data points. Such a kernel function can be learned using deep kernel survival…

机器学习 · 计算机科学 2025-02-18 George H. Chen

Representing, comparing, and measuring the distance between probability distributions is a key task in computational statistics and machine learning. The choice of representation and the associated distance determine properties of the…

机器学习 · 统计学 2026-02-26 Masha Naslidnyk

Extracting rich phenotype information, such as cell density and arrangement, from whole slide histology images (WSIs), requires analysis of large field of view, i.e more contexual information. This can be achieved through analyzing the…

计算机视觉与模式识别 · 计算机科学 2022-03-30 Saarthak Kapse , Srijan Das , Prateek Prasanna

Recently, various deep learning methods have shown significant successes in medical image analysis, especially in the detection of cancer metastases in hematoxylin and eosin (H&E) stained whole-slide images (WSIs). However, in order to…

图像与视频处理 · 电气工程与系统科学 2023-03-21 Yinsheng He , Xingyu Li

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

定量方法 · 定量生物学 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Recent advances in whole-slide image (WSI) scanners and computational capabilities have significantly propelled the application of artificial intelligence in histopathology slide analysis. While these strides are promising, current…

计算机视觉与模式识别 · 计算机科学 2023-11-15 Weiyi Wu , Chongyang Gao , Joseph DiPalma , Soroush Vosoughi , Saeed Hassanpour

Automatic integration of whole slide images (WSIs) and gene expression profiles has demonstrated substantial potential in precision clinical diagnosis and cancer progression studies. However, most existing studies focus on individual gene…

计算机视觉与模式识别 · 计算机科学 2026-01-14 Junzhuo Liu , Xuemei Du , Daniel Reisenbuchler , Ye Chen , Markus Eckstein , Christian Matek , Friedrich Feuerhake , Dorit Merhof

Cancer survival prediction requires integrating pathological Whole Slide Images (WSIs) and genomic profiles, a challenging task due to the inherent heterogeneity and the complexity of modeling both inter- and intra-modality interactions.…

图像与视频处理 · 电气工程与系统科学 2025-07-08 Mingxin Liu , Chengfei Cai , Jun Li , Pengbo Xu , Jinze Li , Jiquan Ma , Jun Xu

Diagnosing medical conditions from histopathology data requires a thorough analysis across the various resolutions of Whole Slide Images (WSI). However, existing generative methods fail to consistently represent the hierarchical structure…

图像与视频处理 · 电气工程与系统科学 2024-07-19 Sarah Cechnicka , James Ball , Matthew Baugh , Hadrien Reynaud , Naomi Simmonds , Andrew P. T. Smith , Catherine Horsfield , Candice Roufosse , Bernhard Kainz

One of the challenges facing the adoption of digital pathology workflows for clinical use is the need for automated quality control. As the scanners sometimes determine focus inaccurately, the resultant image blur deteriorates the scanned…

图像与视频处理 · 电气工程与系统科学 2018-11-16 Mahdi S. Hosseini , Yueyang Zhang , Lyndon Chan , Konstantinos N. Plataniotis , Jasper A. Z. Brawley-Hayes , Savvas Damaskinos

Cancer survival prediction from whole slide images (WSIs) is a challenging task in computational pathology due to the large size, irregular shape, and high granularity of the WSIs. These characteristics make it difficult to capture the full…

图像与视频处理 · 电气工程与系统科学 2025-03-05 Rustin Soraki , Huayu Wang , Joann G. Elmore , Linda Shapiro

Researchers working on computational analysis of Whole Slide Images (WSIs) in histopathology have primarily resorted to patch-based modelling due to large resolution of each WSI. The large resolution makes WSIs infeasible to be fed directly…

计算机视觉与模式识别 · 计算机科学 2021-06-08 Suvidha Tripathi , Satish Kumar Singh , Hwee Kuan Lee

Pathology whole-slide images (WSIs) are widely used for cancer survival analysis because of their comprehensive histopathological information at both cellular and tissue levels, enabling quantitative, large-scale, and prognostically rich…

图像与视频处理 · 电气工程与系统科学 2025-10-02 Yucheng Xing , Ling Huang , Jingying Ma , Ruping Hong , Jiangdong Qiu , Pei Liu , Kai He , Huazhu Fu , Mengling Feng

Multiple instance (MI) learning with a convolutional neural network enables end-to-end training in the presence of weak image-level labels. We propose a new method for aggregating predictions from smaller regions of the image into an…

计算机视觉与模式识别 · 计算机科学 2018-06-14 Heather D. Couture , J. S. Marron , Charles M. Perou , Melissa A. Troester , Marc Niethammer

Microsatellite instability (MSI) is a tumor phenotype whose diagnosis largely impacts patient care in colorectal cancers (CRC), and is associated with response to immunotherapy in all solid tumors. Deep learning models detecting MSI tumors…

图像与视频处理 · 电气工程与系统科学 2022-03-23 Charlie Saillard , Olivier Dehaene , Tanguy Marchand , Olivier Moindrot , Aurélie Kamoun , Benoit Schmauch , Simon Jegou

Existing deep learning methods in multimode fiber (MMF) imaging often focus on simpler datasets, limiting their applicability to complex, real-world imaging tasks. These models are typically data-intensive, a challenge that becomes more…

计算机视觉与模式识别 · 计算机科学 2025-11-26 Jawaria Maqbool , M. Imran Cheema

Multimodal pathology-genomic analysis is critical for cancer survival prediction. However, existing approaches predominantly integrate formalin-fixed paraffin-embedded (FFPE) slides with genomic data, while neglecting the availability of…

计算机视觉与模式识别 · 计算机科学 2025-06-25 Mingcheng Qu , Guang Yang , Donglin Di , Yue Gao , Tonghua Su , Yang Song , Lei Fan

Whole Slide Imaging (WSI) is a cornerstone of digital pathology, offering detailed insights critical for diagnosis and research. Yet, the gigapixel size of WSIs imposes significant computational challenges, limiting their practical utility.…

图像与视频处理 · 电气工程与系统科学 2024-11-15 Ravi Kant Gupta , Shounak Das , Amit Sethi

While Multiple Instance Learning (MIL) has shown promising results in digital Pathology Whole Slide Image (WSI) classification, such a paradigm still faces performance and generalization problems due to challenges in high computational…

计算机视觉与模式识别 · 计算机科学 2023-03-16 Honglin Li , Chenglu Zhu , Yunlong Zhang , Yuxuan Sun , Zhongyi Shui , Wenwei Kuang , Sunyi Zheng , Lin Yang