相关论文: Multi-Modal CLIP-Informed Protein Editing

We propose a novel unsupervised backlit image enhancement method, abbreviated as CLIP-LIT, by exploring the potential of Contrastive Language-Image Pre-Training (CLIP) for pixel-level image enhancement. We show that the open-world CLIP…

Vision-language models (VLMs) have demonstrated exceptional generalization capabilities for downstream tasks. Due to its efficiency, prompt learning has gradually become a more effective and efficient method for transferring VLMs to…

Large pre-trained vision-language models, such as CLIP, have demonstrated state-of-the-art performance across a wide range of image classification tasks, without requiring retraining. Few-shot CLIP is competitive with existing specialized…

CLIP-seq methods are valuable techniques to experimentally determine transcriptome-wide binding sites of RNA-binding proteins. Despite the constant improvement of such techniques (e.g. eCLIP), the results are affected by various types of…

Vision-and-language pretraining (VLP) in the medical field utilizes contrastive learning on image-text pairs to achieve effective transfer across tasks. Yet, current VLP approaches with the masked modeling strategy face two challenges when…

In this study, we propose HOPER (HOlistic ProtEin Representation), a novel multimodal learning framework designed to enhance protein function prediction (PFP) in low-data settings. The challenge of predicting protein functions is compounded…

Proteins are fundamental biological entities that play a key role in life activities. The amino acid sequences of proteins can be folded into stable 3D structures in the real physicochemical world, forming a special kind of…

This work aims to adapt large-scale pre-trained vision-language models, such as contrastive language-image pretraining (CLIP), to enhance the performance of object reidentification (Re-ID) across various supervision settings. Although…

Deep learning has transformed protein design, enabling accurate structure prediction, sequence optimization, and de novo protein generation. Advances in single-chain protein structure prediction via AlphaFold2, RoseTTAFold, ESMFold, and…

Recent advancements in biology and chemistry have leveraged multi-modal learning, integrating molecules and their natural language descriptions to enhance drug discovery. However, current pre-training frameworks are limited to two…

Medical image segmentation remains challenging due to limited annotations for training, ambiguous anatomical features, and domain shifts. While vision-language models such as CLIP offer strong cross-modal representations, their potential…

Contrastive Language-Image Pretraining (CLIP) has achieved remarkable success, leading to rapid advancements in multimodal studies. However, CLIP faces a notable challenge in terms of inefficient data utilization. It relies on a single…

Supervised fine-tuning (SFT) is a standard approach for adapting large language models to specialized domains, yet its application to protein sequence modeling and protein language models (PLMs) remains ad hoc. This is in part because…

Human motion generation is essential for fields such as animation, robotics, and virtual reality, requiring models that effectively capture motion dynamics from text descriptions. Existing approaches often rely on Contrastive Language-Image…

Unlocking the next generation of biotechnology and therapeutic innovation demands overcoming the inherent complexity and resource-intensity of conventional protein engineering methods. Recent GenAI-powered computational techniques often…

Recent state-of-the-art language models utilize a two-phase training procedure comprised of (i) unsupervised pre-training on unlabeled text, and (ii) fine-tuning for a specific supervised task. More recently, many studies have been focused…

Recent advances in generative modeling show that pretrained representations can improve generation as conditioning features or alignment targets. Motivated by this, we study protein representations for predicting structures beyond…

Although natural language instructions offer an intuitive way to guide automated image editing, deep-learning models often struggle to achieve high-quality results, largely due to the difficulty of creating large, high-quality training…

Protein evolution through amino acid mutations is a cornerstone of life sciences. Recent advances in protein language models have shown rich evolutionary patterns, offering unprecedented potential for in-silicon directed evolution. However,…

Prompt tuning introduces learnable prompt vectors that adapt pretrained vision-language models to downstream tasks in a parameter-efficient manner. However, under limited supervision, prompt tuning alters pretrained representations and…