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Bioprinting is an enabling biofabrication technique to create heterogeneous tissue constructs according to patient-specific geometries and compositions. Optimization of bioinks as per requirements for specific tissue applications is a…

材料科学 · 物理学 2022-10-25 Abhinaba Banerjee , Sudipto Datta , Amit Roy Chowdhury , Pallab Datta

Response of the mechanoreceptors underlying the skin is greatly affected by its mechanical properties. Knowledge of this response is essential in designing artificial tactile devices such as minimally invasive tools and tactile displays.…

组织与器官 · 定量生物学 2018-08-31 Roozbeh Khodambashi , S. Najarian , A. T. Golpaygani , A. A. Dehkordi

In the present work, complex irregular bones and joints of the complete human arm were developed in a computer-aided design environment. Finite element analysis of an actual human arm was done to identify the distribution of stress using…

组织与器官 · 定量生物学 2018-07-11 Amit Kumar Bedaka , Ponnusamy Pandithevan

We develop a robust cut finite element method for a model of diffusion in fractured media consisting of a bulk domain with embedded cracks. The crack has its own pressure field and can cut through the bulk mesh in a very general fashion.…

数值分析 · 数学 2020-06-03 Erik Burman , Peter Hansbo , Mats G. Larson

Pimple is one of the most common skin diseases for humans. The mechanical modeling of pimple growth is very limited. A finite element model is developed to quantify the deformation field with the expansion of follicle, and then the…

医学物理 · 物理学 2017-04-07 Xiangbiao Liao , Xiaobin Deng , LiangLiang Zhu , Feng Hao , Hang Xiao , Xiaoyang Shi , Xi Chen

This paper proposes a proof of concept application of a biphasic constitutive model to identify the mechanical properties of in vivo human skin under extension. Although poromechanics theory has been extensively used to model other soft…

We present a finite element modelling approach for unidirectional Fused Filament Fabrication (FFF)-printed specimens under tensile loading. In this study, the focus is on the fracture behaviour, the goal is to simulate the mechanical…

计算物理 · 物理学 2025-02-28 Simon Seibel , Josef Kiendl

A time-dependent modeling framework for autogenous self-healing concrete that couples moisture diffusion with damage evolution was developed. Water transport follows Fick's second law with a damage-dependent diffusivity obtained by…

计算工程、金融与科学 · 计算机科学 2026-03-17 William Liu

A general approach to simulate the mechanical behavior of textile materials by taking into account all their constitutive elementary fibers and contacts between them is presented in this paper. A finite element code, based on an implicit…

材料科学 · 物理学 2009-12-08 Damien Durville

The process of wound healing has been an active area of research around the world. The problem is the wounds of different patients heal differently. For example, patients with a background of diabetes may have difficulties in healing [1].…

医学物理 · 物理学 2022-09-15 Hy Dang

Finite element meshes for 3D models simulating realistic malignant melanoma (MM) growth, incorporating accurate dielectric properties of the skin, have been developed. Numerical simulations illustrate how 3D finite element meshes can be…

数值分析 · 数学 2025-08-12 Eric Lindström , Larisa Beilina

The precise mechanisms underlying the failure of multi-phase materials may be strongly dependent on the material's microstructural morphology. Micromechanical modeling has provided much insight into this dependence, but uncertainties remain…

材料科学 · 物理学 2016-04-14 T. W. J. de Geus , R. H. J. Peerlings , M. G. D. Geers

Wounds in epithelial tissues compromise their vital role in homeostasis. A rapid and efficient wound healing encompasses different mechanisms, which includes the formation of a contractile actin-myosin cable around its edge, known as the…

软凝聚态物质 · 物理学 2024-03-22 R. F. Almada , N. A. M. Araujo , P. Patricio

This study presents a mathematical model formulated as a system of first-order non-linear ordinary differential equations, aimed at examining the effects of different factors, classified as local and systemic factors on a wound healing…

其他定量生物学 · 定量生物学 2025-09-16 Alinafe Maenje , Joseph Malinzi

When modelling discontinuities (interfaces) using the finite element method, the standard approach is to use a conforming finite-element mesh in which the mesh matches the interfaces. However, this approach can prove cumbersome if the…

计算工程、金融与科学 · 计算机科学 2024-06-06 Jedrzej Dobrzanski , Kajetan Wojtacki , Stanislaw Stupkiewicz

The developed computational approach is capable of initiating and propagating cracks inside materials and along material interfaces of general multi-domain structures under quasi-static conditions. Special attention is paid to particular…

计算工程、金融与科学 · 计算机科学 2023-08-23 Roman Vodička

Diabetic foot ulcers are triggered by mechanical loadings applied to the surface of the plantar skin. Strain is considered to play a crucial role in relation to ulcer etiology and can be assessed by Finite Element (FE) modelling. A…

医学物理 · 物理学 2023-07-19 Alessio Trebbi , Nolwenn Fougeron , Yohan Payan

In this paper we propose a novel coupled poroelasticity-diffusion model for the formation of extracellular oedema and infectious myocarditis valid in large deformations, manifested as an interaction between interstitial flow and the…

The modeling of damage processes in materials constitutes an ill-posed mathematical problem which manifests in mesh-dependent finite element results. The loss of ellipticity of the discrete system of equations is counteracted by…

计算工程、金融与科学 · 计算机科学 2021-02-18 Philipp Junker , Johannes Riesselmann , Daniel Balzani

Pressure ulcers are a severe disease affecting patients that are bedridden or in a wheelchair bound for long periods of time. These wounds can develop in the deep layers of the skin of specific parts of the body, mostly on heels or sacrum,…

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