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We consider a simulation-based Ranking and Selection (R&S) problem with input uncertainty, where unknown input distributions can be estimated using input data arriving in batches of varying sizes over time. Each time a batch arrives,…

最优化与控制 · 数学 2022-09-05 Di Wu , Yuhao Wang , Enlu Zhou

Estimating the conditional average treatment effect (CATE) from observational data plays a crucial role in areas such as e-commerce, healthcare, and economics. Existing studies mainly rely on the strong ignorability assumption that there…

机器学习 · 计算机科学 2025-01-28 Chuan Zhou , Yaxuan Li , Chunyuan Zheng , Haiteng Zhang , Haoxuan Li , Mingming Gong

The goal of precision medicine is to provide individualized treatment at each stage of chronic diseases, a concept formalized by Dynamic Treatment Regimes (DTR). These regimes adapt treatment strategies based on decision rules learned from…

统计方法学 · 统计学 2025-06-09 Sophia Yazzourh , Nicolas Savy , Philippe Saint-Pierre , Michael R. Kosorok

CIMTx provides efficient and unified functions to implement modern methods for causal inferences with multiple treatments using observational data with a focus on binary outcomes. The methods include regression adjustment, inverse…

统计方法学 · 统计学 2022-09-15 Liangyuan Hu , Jiayi Ji

How do we know if a particular medical treatment actually works? Ideally one would consult all available evidence from relevant clinical trials. Unfortunately, such results are primarily disseminated in natural language scientific articles,…

计算与语言 · 计算机科学 2019-04-08 Eric Lehman , Jay DeYoung , Regina Barzilay , Byron C. Wallace

We argue that randomized controlled trials (RCTs) are special even among settings where average treatment effects are identified by a nonparametric unconfoundedness assumption. This claim follows from two results of Robins and Ritov (1997):…

统计方法学 · 统计学 2021-09-28 P. M. Aronow , James M. Robins , Theo Saarinen , Fredrik Sävje , Jasjeet Sekhon

While randomised controlled trials (RCTs) are the gold standard for estimating causal treatment effects, their limited sample sizes and restrictive criteria make it difficult to extrapolate to a broader population. Observational data, while…

统计方法学 · 统计学 2025-09-09 Stephanie Riley , Ricardo Silva , Matthew Sperrin

Drawing meaningful conclusions from inherently multimodal clinical data (including medical imaging) requires coordinating expertise across the clinical specialty, radiology, programming, and biostatistics. This fragmented process…

多智能体系统 · 计算机科学 2026-04-15 Lucas Stoffl , Benedikt Wiestler , Johannes C. Paetzold

Reinforcement learning (RL) is a promising approach to generate treatment policies for sepsis patients in intensive care. While retrospective evaluation metrics show decreased mortality when these policies are followed, studies with…

机器学习 · 计算机科学 2024-04-11 Unnseo Park , Venkatesh Sivaraman , Adam Perer

A dynamic treatment regimen (DTR) is a pre-specified sequence of decision rules which maps baseline or time-varying measurements on an individual to a recommended intervention or set of interventions. Sequential multiple assignment…

统计方法学 · 统计学 2019-10-23 Brook Luers , Min Qian , Inbal Nahum-Shani , Connie Kasari , Daniel Almirall

We address zero-shot TTS systems' noise-robustness problem by proposing a dual-objective training for the speaker encoder using self-supervised DINO loss. This approach enhances the speaker encoder with the speech synthesis objective,…

Observed events in recommendation are consequence of the decisions made by a policy, thus they are usually selectively labeled, namely the data are Missing Not At Random (MNAR), which often causes large bias to the estimate of true outcomes…

机器学习 · 计算机科学 2021-10-05 Zifeng Wang , Xi Chen , Rui Wen , Shao-Lun Huang

Randomised controlled trials (RCTs) are regarded as the gold standard for estimating causal treatment effects on health outcomes. However, RCTs are not always feasible, because of time, budget or ethical constraints. Observational data such…

统计方法学 · 统计学 2024-02-20 Li Su , Roonak Rezvani , Shaun R. Seaman , Colin Starr , Isaac Gravestock

Randomized controlled trials (RCTs) are the standard for evaluating the effectiveness of clinical interventions. To address the limitations of RCTs on real-world populations, we developed a methodology that uses a large observational…

机器学习 · 计算机科学 2024-10-21 Panayiotis Petousis , David Gordon , Susanne B. Nicholas , Alex A. T. Bui

It is well known that for some tasks, labeled data sets may be hard to gather. Therefore, we wished to tackle here the problem of having insufficient training data. We examined learning methods from unlabeled data after an initial training…

机器学习 · 计算机科学 2018-04-06 Gal Hyams , Daniel Greenfeld , Dor Bank

Predicting which action (treatment) will lead to a better outcome is a central task in decision support systems. To build a prediction model in real situations, learning from biased observational data is a critical issue due to the lack of…

机器学习 · 统计学 2020-06-11 Akira Tanimoto , Tomoya Sakai , Takashi Takenouchi , Hisashi Kashima

Learning to adapt pretrained language models to unlabeled, out-of-distribution data is a critical challenge, as models often falter on structurally novel reasoning tasks even while excelling within their training distribution. We introduce…

计算与语言 · 计算机科学 2025-05-29 Mohammad Mahdi Moradi , Hossam Amer , Sudhir Mudur , Weiwei Zhang , Yang Liu , Walid Ahmed

We demonstrate a simple strategy to cope with missing data in sequential inputs, addressing the task of multilabel classification of diagnoses given clinical time series. Collected from the pediatric intensive care unit (PICU) at Children's…

机器学习 · 计算机科学 2016-11-14 Zachary C. Lipton , David C. Kale , Randall Wetzel

Abstruse learning algorithms and complex datasets increasingly characterize modern clinical decision support systems (CDSS). As a result, clinicians cannot easily or rapidly scrutinize the CDSS recommendation when facing a difficult…

人工智能 · 计算机科学 2021-11-02 Bojian Hou , Hao Zhang , Gur Ladizhinsky , Gur Ladizhinsky , Stephen Yang , Volodymyr Kuleshov , Fei Wang , Qian Yang

The regression discontinuity (RD) design is widely used for program evaluation with observational data. The primary focus of the existing literature has been the estimation of the local average treatment effect at the existing treatment…

统计方法学 · 统计学 2024-09-05 Yi Zhang , Eli Ben-Michael , Kosuke Imai