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Existing causal methods for time-varying exposure and time-varying confounding focus on estimating the average causal effect of a time-varying binary treatment on an end-of-study outcome, offering limited tools for characterizing marginal…

统计方法学 · 统计学 2026-01-21 Yu Luo , Kuan Liu , Ramandeep Singh , Daniel J. Graham

We propose a statistical method for clustering of multivariate longitudinal data into homogeneous groups. This method relies on a time-varying extension on the classical K-means algorithm, where a multivariate vector autoregressive model is…

统计方法学 · 统计学 2014-04-25 Antonello Maruotti , Maurizio Vichi

In epidemiological disease mapping one aims to estimate the spatio-temporal pattern in disease risk and identify high-risk clusters, allowing health interventions to be appropriately targeted. Bayesian spatio-temporal models are used to…

统计方法学 · 统计学 2014-11-11 Duncan Lee , Andrew Lawson

Recurrent event data are common in clinical studies when participants are followed longitudinally, and are often subject to a terminal event. With the increasing popularity of large pragmatic trials with a heterogeneous source population,…

统计方法学 · 统计学 2022-12-06 Xinyuan Tian , Maria Ciarleglio , Jiachen Cai , Erich Greene , Denise Esserman , Fan Li , Yize Zhao

Time Varying Functional Connectivity (TVFC) investigates how the interactions among brain regions vary over the course of an fMRI experiment. The transitions between different individual connectivity states can be modulated by changes in…

Physical activity is crucial for human health. With the increasing availability of large-scale mobile health data, strong associations have been found between physical activity and various diseases. However, accurately capturing this…

应用统计 · 统计学 2025-01-03 Xiaojing Sun , Bingxin Zhao , Fei Xue

In many applications, it is of interest to study trends over time in relationships among categorical variables, such as age group, ethnicity, religious affiliation, political party and preference for particular policies. At each time point,…

统计方法学 · 统计学 2012-05-15 Tsuyoshi Kunihama , David B. Dunson

Joint models for a wide class of response variables and longitudinal measurements consist on a mixed-effects model to fit longitudinal trajectories whose random effects enter as covariates in a generalized linear model for the primary…

统计方法学 · 统计学 2014-07-03 Rolando De la Cruz , Cristian Meza , Ana Arribas-Gil , Raymond J. Carroll

Several factors make clustering of functional data challenging, including the infinite-dimensional space to which observations belong and the lack of a defined probability density function for the functional random variable. To overcome…

统计方法学 · 统计学 2025-02-03 Andi Mai , Lan Xue , Roger Zoh , Carmen Tekwe

Functional data, with basic observational units being functions (e.g., curves, surfaces) varying over a continuum, are frequently encountered in various applications. While many statistical tools have been developed for functional data…

统计方法学 · 统计学 2016-06-10 Jingjing Yang , Hongxiao Zhu , Taeryon Choi , Dennis D. Cox

Heterogeneous treatment effect estimation is critical in oncology, particularly in multi-arm trials with overlapping therapeutic components and long-term survivors. These shared mechanisms pose a central challenge to identifying causal…

统计方法学 · 统计学 2025-10-29 Peter Chang , John Kairalla , Arkaprava Roy

In heterogeneous disorders like Parkinson's disease (PD), differentiating the affected population into subgroups plays a key role in future research. Discovering subgroups can lead to improved treatments through more powerful enrichment of…

统计方法学 · 统计学 2023-08-08 Elliot Burghardt , Daniel Sewell , Joseph Cavanaugh

This paper demonstrates the advantages of sharing information about unknown features of covariates across multiple model components in various nonparametric regression problems including multivariate, heteroscedastic, and semi-continuous…

统计方法学 · 统计学 2019-06-11 Antonio R. Linero , Debajyoti Sinha , Stuart R. Lipsitz

We introduce a Bayesian nonparametric inference approach for aggregate adverse event (AE) monitoring across studies. The proposed model seamlessly integrates external data from historical trials to define a relevant background rate and…

统计方法学 · 统计学 2025-09-10 Shijie Yuan , Kevin Roberts , Noirrit Kiran Chandra , Yuan Ji , Peter Müller

This paper presents SeqClusFD, a top-down sequential clustering method for functional data. The clustering algorithm extracts the splitting information either from trajectories, first or second derivatives. Initial partition is based on gap…

统计方法学 · 统计学 2023-12-29 Ana Justel , Marcela Svarc

We conduct cluster analysis on a class of locally asymptotically self-similar stochastic processes, which includes multifractional Brownian motion as a representative. When the true number of clusters is supposed to be known, a new…

机器学习 · 统计学 2020-01-15 Qidi Peng , Nan Rao , Ran Zhao

This article introduces a nonparametric approach to spectral analysis of a high-dimensional multivariate nonstationary time series. The procedure is based on a novel frequency-domain factor model that provides a flexible yet parsimonious…

统计方法学 · 统计学 2019-10-29 Zeda Li , Ori Rosen , Fabio Ferrarelli , Robert T. Krafty

Bayesian hierarchical modeling is a natural framework to effectively integrate data and borrow information across groups. In this paper, we address problems related to density estimation and identifying clusters across related groups, by…

统计方法学 · 统计学 2025-10-29 Huizi Zhang , Sara Wade , Natalia Bochkina

A model-based approach is developed for clustering categorical data with no natural ordering. The proposed method exploits the Hamming distance to define a family of probability mass functions to model the data. The elements of this family…

统计方法学 · 统计学 2024-07-02 Raffaele Argiento , Edoardo Filippi-Mazzola , Lucia Paci

Modeling and computation for multivariate longitudinal surveys have proven challenging, particularly when data are not all continuous and Gaussian but contain discrete measurements. In many social science surveys, study participants are…

应用统计 · 统计学 2016-06-09 Tsuyoshi Kunihama , Carolyn T. Halpern , Amy H. Herring