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Image-based or morphological profiling is a rapidly expanding field wherein cells are "profiled" by extracting hundreds to thousands of unbiased, quantitative features from images of cells that have been perturbed by genetic or chemical…

定量方法 · 定量生物学 2024-11-07 Erin Weisbart , Ankur Kumar , John Arevalo , Anne E. Carpenter , Beth A. Cimini , Shantanu Singh

For over two decades, image-based profiling has revolutionized cell phenotype analysis. Image-based profiling processes rich, high-throughput, microscopy data into thousands of unbiased measurements that reveal phenotypic patterns powerful…

Large-scale biological discovery requires integrating massive, heterogeneous datasets like those from the JUMP Cell Painting consortium, but technical batch effects and a lack of generalizable models remain critical roadblocks. To address…

计算机视觉与模式识别 · 计算机科学 2025-09-10 Cedric Caruzzo , Jong Chul Ye

Understanding the mechanisms of interactions within cells, tissues, and organisms is crucial to driving developments across biology and medicine. Mathematical modeling is an essential tool for simulating biological systems and revealing…

分子网络 · 定量生物学 2024-08-13 Lingxia Qiao , Ali Khalilimeybodi , Nathaniel J Linden-Santangeli , Padmini Rangamani

Cell painting is a popular technique for creating human-interpretable, high-contrast images of cell morphology. There are two major issues with cell paint: (1) it is labor-intensive and (2) it requires chemical fixation, making the study of…

计算机视觉与模式识别 · 计算机科学 2025-12-16 Alexander Peysakhovich , William Berman , Joseph Rufo , Felix Wong , Maxwell Z. Wilson

We present a new annotated microscopic cellular image dataset to improve the effectiveness of machine learning methods for cellular image analysis. Cell counting is an important step in cell analysis. Typically, domain experts manually…

图像与视频处理 · 电气工程与系统科学 2024-11-20 Abdurahman Ali Mohammed , Catherine Fonder , Donald S. Sakaguchi , Wallapak Tavanapong , Surya K. Mallapragada , Azeez Idris

Microscopy image enhancement plays a pivotal role in understanding the details of biological cells and materials at microscopic scales. In recent years, there has been a significant rise in the advancement of microscopy image enhancement,…

图像与视频处理 · 电气工程与系统科学 2025-09-29 Debasish Dutta , Neeharika Sonowal , Risheraj Barauh , Deepjyoti Chetia , Sanjib Kr Kalita

The cost of some drugs and medical treatments has risen in recent years that many patients are having to go without. A classification project could make researchers more efficient. One of the more surprising reasons behind the cost is how…

计算机视觉与模式识别 · 计算机科学 2020-07-14 Manik Sharma , Ganapathy Krishnamurthi

Cell image classification methods are currently being used in numerous applications in cell biology and medicine. Applications include understanding the effects of genes and drugs in screening experiments, understanding the role and…

定量方法 · 定量生物学 2022-03-04 Mohammad Shifat-E-Rabbi , Xuwang Yin , Cailey Elizabeth Fitzgerald , Gustavo K. Rohde

Cancer is one of the leading causes of death worldwide. Fast and safe early-stage, pre- and intra-operative diagnostics can significantly contribute to successful cancer identification and treatment. Artificial intelligence has played an…

组织与器官 · 定量生物学 2022-08-10 Marina Zajnulina

Understanding the morphological changes of primary neuronal cells induced by chemical compounds is essential for drug discovery. Using the data from a single high-throughput imaging assay, a classification model for predicting the…

图像与视频处理 · 电气工程与系统科学 2019-09-02 Andrey Kormilitzin , Xinyu Yang , William H. Stone , Caroline Woffindale , Francesca Nicholls , Elena Ribe , Alejo Nevado-Holgado , Noel Buckley

Histopathological images contain rich phenotypic information that can be used to monitor underlying mechanisms contributing to diseases progression and patient survival outcomes. Recently, deep learning has become the mainstream…

图像与视频处理 · 电气工程与系统科学 2020-10-28 Chetan L. Srinidhi , Ozan Ciga , Anne L. Martel

From Paleolithic cave paintings to Impressionism, human painting has evolved to depict increasingly complex and detailed scenes, conveying more nuanced messages. This paper attempts to emerge this artistic capability by simulating the…

计算机视觉与模式识别 · 计算机科学 2025-01-10 Yi Lin , Lin Gu , Ziteng Cui , Shenghan Su , Yumo Hao , Yingtao Tian , Tatsuya Harada , Jianfei Yang

Computer-aided diagnosis (CAD), a vibrant medical imaging research field, is expanding quickly. Because errors in medical diagnostic systems might lead to seriously misleading medical treatments, major efforts have been made in recent years…

机器学习 · 计算机科学 2023-08-04 Farzaneh Tajidini , Mohammad-Javad Kheiri

The advent of the era of machines has limited human interaction and this has increased their presence in the last decade. The requirement to increase the effectiveness, durability and reliability in the robots has also risen quite…

计算机视觉与模式识别 · 计算机科学 2020-10-05 Soham Shah , Siddhi Vinayak Pandey , Archit Sorathiya , Raj Sheth , Alok Kumar Singh , Jignesh Thaker

Morphological profiling is a valuable tool in phenotypic drug discovery. The advent of high-throughput automated imaging has enabled the capturing of a wide range of morphological features of cells or organisms in response to perturbations…

Pathology deals with the practice of discovering the reasons for disease by analyzing the body samples. The most used way in this field, is to use histology which is basically studying and viewing microscopic structures of cell and tissues.…

图像与视频处理 · 电气工程与系统科学 2021-11-08 Virender Ranga , Shivam Gupta , Priyansh Agrawal , Jyoti Meena

Painting is an art form that has long functioned as a major channel for the creative expression and communication of humans, its evolution taking place under an interplay with the science, technology, and social environments of the times.…

计算机视觉与模式识别 · 计算机科学 2018-10-04 Byunghwee Lee , Daniel Kim , Seunghye Sun , Hawoong Jeong , Juyong Park

With the growth of artificial intelligence (AI), there has been an increase in the adoption of computer vision and deep learning (DL) techniques for the evaluation of microscopy images and movies. This adoption has not only addressed…

定量方法 · 定量生物学 2023-07-21 Binghao Chai , Christoforos Efstathiou , Haoran Yue , Viji M. Draviam

Cell biomechanics involve a great number of complex phenomena that are fundamental to the evolution of life itself and other associated processes, ranging from the very early stages of embryo-genesis to the maintenance of damaged structures…

计算机视觉与模式识别 · 计算机科学 2025-09-09 Juan Olalla-Pombo , Alberto Badías , Miguel Ángel Sanz-Gómez , José María Benítez , Francisco Javier Montáns
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