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The identification of predictive biomarkers from a large scale of covariates for subgroup analysis has attracted fundamental attention in medical research. In this article, we propose a generalized penalized regression method with a novel…

统计方法学 · 统计学 2019-04-29 Chong Ma , Wenxuan Deng , Shuangge Ma , Ray Liu , Kevin Galinsky

When examining a contrast between two interventions, longitudinal causal inference studies frequently encounter positivity violations when one or both regimes are impossible to observe for some subjects. Existing weighting methods either…

统计方法学 · 统计学 2025-08-11 Alec McClean , Iván Díaz

We propose a simple, statistically principled, and theoretically justified method to improve supervised learning when the training set is not representative, a situation known as covariate shift. We build upon a well-established methodology…

机器学习 · 统计学 2025-03-12 Maximilian Autenrieth , David A. van Dyk , Roberto Trotta , David C. Stenning

Subclassification estimators are one of the methods used to estimate causal effects of interest using the propensity score. This method is more stable compared to other weighting methods, such as inverse probability weighting estimators, in…

统计方法学 · 统计学 2024-10-22 Shunichiro Orihara , Tomotaka Momozaki

In observational clinic registries, time to treatment is often of interest, but treatment can be given at any time during follow-up and there is no structure or intervention to ensure regular clinic visits for data collection. To address…

统计方法学 · 统计学 2019-05-07 Pallavi S. Mishra-Kalyani , Brent A. Johnson , Qi Long

In the absence of unobserved confounders, matching and weighting methods are widely used to estimate causal quantities including the Average Treatment Effect on the Treated (ATT). Unfortunately, these methods do not necessarily achieve…

统计方法学 · 统计学 2016-05-03 Chad Hazlett

In observational studies, weighting methods that directly optimize the balance between treatment and covariates have received much attention lately; however these have mainly focused on binary treatments. Inspired by domain adaptation, we…

统计理论 · 数学 2020-02-27 Guillaume Martinet

The research described herewith is to re-visit the classical doubly robust estimation of average treatment effect by conducting a systematic study on the comparisons, in the sense of asymptotic efficiency, among all possible combinations of…

统计理论 · 数学 2020-06-01 Keli Guo , Chuyun Ye , Jun Fan , Lixing Zhu

Weighting methods are used in observational studies to adjust for covariate imbalances between treatment and control groups. Entropy balancing (EB) is an alternative to inverse probability weighting with an estimated propensity score. The…

统计方法学 · 统计学 2022-04-25 David Källberg , Ingeborg Waernbaum

Cluster-randomized trials (CRTs) involve randomizing entire groups of participants -- called clusters -- to treatment arms but are often comprised of a limited or fixed number of available clusters. While covariate adjustment can account…

统计方法学 · 统计学 2022-11-29 Angela Y. Zhu , Nandita Mitra , Karla Hemming , Michael O. Harhay , Fan Li

Borrowing external data can improve estimation efficiency but may introduce bias when populations differ in covariate distributions or outcome variability. A proper balance needs to be maintained between the two datasets to justify the…

统计方法学 · 统计学 2026-01-08 Apu Chandra Das , Sakib Salam , Aninda Roy , Rakhi Chowdhury , Antar Chandra Das , Ashim Chandra Das

The inverse probability weighting approach is popular for evaluating treatment effects in observational studies, but extreme propensity scores could bias the estimator and induce excessive variance. Recently, the overlap weighting approach…

统计方法学 · 统计学 2022-06-22 Chao Cheng , Fan Li , Laine Thomas , Fan Li

Many spatial phenomena exhibit treatment interference where treatments at one location may affect the response at other locations. Because interference violates the stable unit treatment value assumption, standard methods for causal…

统计方法学 · 统计学 2020-07-02 Andrew Giffin , Brian Reich , Shu Yang , Ana Rappold

A common concern in observational studies focuses on properly evaluating the causal effect, which usually refers to the average treatment effect or the average treatment effect on the treated. In this paper, we propose a data preprocessing…

统计方法学 · 统计学 2021-01-12 Xialing Wen , Ying Yan , Wenliang Pan , Xianyang Zhang

This paper develops new methods for causal inference in observational studies on a single large network of interconnected units, addressing two key challenges: long-range dependence among units and the presence of general interference. We…

统计方法学 · 统计学 2025-11-24 Jizhou Liu , Dake Zhang , Eric J. Tchetgen Tchetgen

Subgroup analysis is a frequently used tool for evaluating heterogeneity of treatment effect and heterogeneity in treatment harm across observed baseline patient characteristics. While treatment efficacy and adverse event measures are often…

应用统计 · 统计学 2018-08-14 Nicholas C. Henderson , Ravi Varadhan

This study investigates the application of quantum neural networks (QNNs) for propensity score estimation to address selection bias in comparing survival outcomes between laparoscopic and open surgical techniques in a cohort of 1177…

量子物理 · 物理学 2025-06-26 Vojtěch Novák , Ivan Zelinka , Lenka Přibylová , Lubomír Martínek

Many research questions in public health and medicine concern sustained interventions in populations defined by substantive priorities. Existing methods to answer such questions typically require a measured covariate set sufficient to…

统计方法学 · 统计学 2023-06-30 Audrey Renson , Michael Hudgens , Alexander Keil , Paul Zivich , Allison Aiello

Flexible estimation of the mean outcome under a treatment regimen (i.e., value function) is the key step toward personalized medicine. We define our target parameter as a conditional value function given a set of baseline covariates which…

统计理论 · 数学 2023-09-29 Ashkan Ertefaie , Luke Duttweiler , Brent A. Johnson , Mark J. van der Laan

G-computation has become a widely used robust method for estimating unconditional (marginal) treatment effects with covariate adjustment in the analysis of randomized clinical trials. Statistical inference in this context typically relies…

统计方法学 · 统计学 2025-03-18 Xin Zhang , Haitao Chu , Lin Liu , Satrajit Roychoudhury