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Genetic interactions confer robustness on cells in response to genetic perturbations. This often occurs through molecular buffering mechanisms that can be predicted using, among other features, the degree of coexpression between genes,…

定量方法 · 定量生物学 2017-03-14 Alberto Roverato , Robert Castelo

A graphical model provides a compact and efficient representation of the association structure of a multivariate distribution by means of a graph. Relevant features of the distribution are represented by vertices, edges and other…

统计理论 · 数学 2020-09-03 Alberto Roverato , Robert Castelo

The edge structure of the graph defining an undirected graphical model describes precisely the structure of dependence between the variables in the graph. In many applications, the dependence structure is unknown and it is desirable to…

机器学习 · 统计学 2018-08-01 Marina Vinyes , Guillaume Obozinski

Mediation analysis seeks to infer how much of the effect of an exposure on an outcome can be attributed to specific pathways via intermediate variables or mediators. This requires identification of so-called path-specific effects. These…

统计方法学 · 统计学 2019-06-06 Johan Steen , Stijn Vansteelandt

Partial correlations quantify linear association between two variables adjusting for the influence of the remaining variables. They form the backbone for graphical models and are readily obtained from the inverse of the covariance matrix.…

统计方法学 · 统计学 2019-04-23 Ionas Erb

We know that the marginals in a multinomial distribution are binomial variates exhibiting a negative correlation. But we can construct two linear combinations of such marginals in such a way to obtain a positive correlation. We discuss the…

离散数学 · 计算机科学 2007-05-23 Mario Catalani

A fundamental research question is how much a variation in a covariate influences a binary response variable in a logistic regression model, both directly or through mediators. We derive the exact formula linking the parameters of marginal…

统计理论 · 数学 2019-05-20 Elena Stanghellini , Marco Doretti

In linear regression modelling the distortion of effects after marginalizing over variables of the conditioning set has been widely studied in several contexts. For Gaussian variables, the relationship between marginal and partial…

统计方法学 · 统计学 2018-05-08 Monia Lupparelli

The graphical representation of the correlation matrix by means of different multivariate statistical methods is reviewed, a comparison of the different procedures is presented with the use of an example data set, and an improved…

统计计算 · 统计学 2024-01-24 Jan Graffelman , Jan de Leeuw

Two popular approaches for relating correlated measurements of a non-Gaussian response variable to a set of predictors are to fit a marginal model using generalized estimating equations and to fit a generalized linear mixed model by…

统计方法学 · 统计学 2017-02-23 Jeffrey J. Gory , Peter F. Craigmile , Steven N. MacEachern

Graphical model selection is a seemingly impossible task when many pairs of variables are never jointly observed; this requires inference of conditional dependencies with no observations of corresponding marginal dependencies. This…

统计理论 · 数学 2023-02-16 Giuseppe Vinci , Gautam Dasarathy , Genevera I. Allen

Nonlinear relations, such as the curvilinear relationship between childhood trauma and resilience in patients with schizophrenia and the moderation relationship between mentalizing, and internalizing and externalizing symptoms and quality…

统计方法学 · 统计学 2025-09-16 Lindley R. Slipetz , Jiaxing Qiu , Siqi Sun , Teague R. Henry

To take sample biases and skewness in the observations into account, practitioners frequently weight their observations according to some marginal distribution. The present paper demonstrates that such weighting can indeed improve the…

统计方法学 · 统计学 2018-11-05 Tobias Niebuhr , Mathias Trabs

We review some not well known results about marginal log-linear models, derive some new ones and show how they might be relevant in mediation analysis within logistic regression. In particular, we elaborate on the relation between…

统计方法学 · 统计学 2022-04-20 Antonio Forcina

In Gaussian graphical models, conditional independence and partial correlations are natural inferential targets for understanding direct relationships in multivariate data. No comparable framework exists for spatial processes, where…

统计方法学 · 统计学 2026-04-14 Michele Peruzzi

The decomposition of the overall effect of a treatment into direct and indirect effects is here investigated with reference to a recursive system of binary random variables. We show how, for the single mediator context, the marginal effect…

统计方法学 · 统计学 2025-11-14 Martina Raggi , Elena Stanghellini , Marco Doretti

The Gaussian graphical model (GGM) has become a popular tool for analyzing networks of psychological variables. In a recent paper in this journal, Forbes, Wright, Markon, and Krueger (FWMK) voiced the concern that GGMs that are estimated…

统计方法学 · 统计学 2020-07-22 Lourens Waldorp , Maarten Marsman

Most real-world networks are weighted graphs with the weight of the edges reflecting the relative importance of the connections. In this work, we study non degree dependent correlations between edge weights, generalizing thus the…

统计力学 · 物理学 2009-11-11 Jose J. Ramasco , Bruno Goncalves

We introduce Network Maximal Correlation (NMC) as a multivariate measure of nonlinear association among random variables. NMC is defined via an optimization that infers transformations of variables by maximizing aggregate inner products…

机器学习 · 统计学 2017-02-13 Soheil Feizi , Ali Makhdoumi , Ken Duffy , Muriel Medard , Manolis Kellis

Marginal models involve restrictions on the conditional and marginal association structure of a set of categorical variables. They generalize log-linear models for contingency tables, which are the fundamental tools for modelling the…

统计方法学 · 统计学 2023-04-10 Tamas Rudas , Wicher Bergsma
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