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Glaucoma is the leading cause of irreversible but preventable blindness in the world. Its major treatable risk factor is the intra-ocular pressure, although other biomarkers are being explored to improve the understanding of the…

计算机视觉与模式识别 · 计算机科学 2018-10-26 José Ignacio Orlando , João Barbosa Breda , Karel van Keer , Matthew B. Blaschko , Pablo J. Blanco , Carlos A. Bulant

Recent progress in artificial intelligence (AI) and high-performance computing (HPC) have brought potentially game-changing opportunities in accelerating reactive flow simulations. In this study, we introduce an open-source computational…

计算工程、金融与科学 · 计算机科学 2023-12-22 Runze Mao , Yingrui Wang , Min Zhang , Han Li , Jiayang Xu , Xinyu Dong , Yan Zhang , Zhi X. Chen

Background and Objective: This proof of concept study investigates mathematical modelling of blood flow and oxygen transport in cerebral microcirculation, focusing on understanding hemodynamic responses. By coupling oxygen transport models…

数值分析 · 数学 2024-11-19 Maryam Samavaki , Santtu Söderholm , Arash Zarrin Nia , Sampsa Pursiainen

Intracranial aneurysms (IAs) are serious cerebrovascular lesions found in approximately 5\% of the general population. Their rupture may lead to high mortality. Current methods for assessing IA risk focus on morphological and…

Image-based computational fluid dynamics (CFD) modeling enables derivation of hemodynamic information, which has become a paradigm in cardiovascular research and healthcare. Nonetheless, the predictive accuracy largely depends on precisely…

流体动力学 · 物理学 2021-07-20 Han Gao , Xueyu Zhu , Jian-Xun Wang

Background: Non-invasive imaging-based assessment of blood flow plays a critical role in evaluating heart function and structure. Computed Tomography (CT) is a widely-used imaging modality that can robustly evaluate cardiovascular anatomy…

图像与视频处理 · 电气工程与系统科学 2025-11-07 Jinyuxuan Guo , Gurnoor Singh Khurana , Alejandro Gonzalo Grande , Juan C. del Alamo , Francisco Contijoch

Cerebral aneurysms are pathological dilations of intracranial arteries that can rupture with devastating consequences, including subarachnoid hemorrhage, stroke, and death. Accumulating evidence indicates that local hemodynamic forces play…

其他定量生物学 · 定量生物学 2025-05-22 Reza Bozorgpour , Pilwan Kim

Transient computational fluid dynamics (CFD) simulations are essential for many industrial applications, but suffer from high compute costs relative to steady-state simulations. This is due to the need to: (a) reach statistical steadiness…

Diffuse Correlation Spectroscopy (DCS) allows the label-free investigation of microvascular dynamics deep within living tissue. However, common implementations of DCS are currently limited to measurement depths of $\sim 1-1.5cm$, which can…

Despite rapid improvements in the performance of central processing unit (CPU), the calculation cost of simulating chemically reacting flow using CFD remains infeasible in many cases. The application of the convolutional neural networks…

机器学习 · 计算机科学 2023-07-26 Joongoo Jeon , Juhyeong Lee , Sung Joong Kim

Accurate prediction of cerebral blood flow is essential for the diagnosis and treatment of cerebrovascular diseases. Traditional computational methods, however, often incur significant computational costs, limiting their practicality in…

图像与视频处理 · 电气工程与系统科学 2024-11-28 Seungyeon Kim , Wheesung Lee , Sung-Ho Ahn , Do-Eun Lee , Tae-Rin Lee

Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…

机器学习 · 计算机科学 2019-09-19 Georgios Kissas , Yibo Yang , Eileen Hwuang , Walter R. Witschey , John A. Detre , Paris Perdikaris

In this work, we present mixed dimensional models for simulating blood flow and transport processes in breast tissue and the vascular tree supplying it. These processes are considered, to start from the aortic inlet to the capillaries and…

组织与器官 · 定量生物学 2022-10-10 Marvin Fritz , Tobias Köppl , J. Tinsley Oden , Andreas Wagner , Barbara Wohlmuth , Chengyue Wu

Vascular calcification is implicated as an important factor in major adverse cardiovascular events (MACE), including heart attack and stroke. A controversy remains over how to integrate the diverse forms of vascular calcification into…

计算机视觉与模式识别 · 计算机科学 2024-01-18 Mehdi Ramezanpour , Anne M. Robertson , Yasutaka Tobe , Xiaowei Jia , Juan R. Cebral

Background: Chronic rhinosinusitis (CRS) is a prevalent and disruptive disease. Medical management including nasal steroid sprays is the primary treatment modality. Computational fluid dynamics (CFD) has been used to characterize sinonasal…

Numerical simulation of fluids plays an essential role in modeling many physical phenomena, which enables technological advancements, contributes to sustainable practices, and expands our understanding of various natural and engineered…

Numerical simulations of blood flow are a valuable tool to investigate the pathophysiology of ascending thoracic aortic aneurysms (ATAA). To accurately reproduce hemodynamics, computational fluid dynamics (CFD) models must employ realistic…

One of the current challenges in physically-based simulations, and, more specifically, fluid simulations, is to produce visually appealing results at interactive rates, capable of being used in multiple forms of media. In recent times, a…

图形学 · 计算机科学 2024-04-17 Pedro Centeno , João Madeiras Pereira

The analysis of quantitative hemodynamics and luminal pressure may add valuable information to aid treatment strategies and prognosis for aortic dissections. This work directly compared in vitro 4D-flow magnetic resonance imaging (MRI),…

Blood flow imaging provides important information for hemodynamic behavior within the vascular system and plays an essential role in medical diagnosis and treatment planning. However, obtaining high-quality flow images remains a significant…

数值分析 · 数学 2026-04-02 Han Zhang , Xue-Cheng Tai , Jean-Michel Morel , Raymond H. Chan