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When performing an analysis on a collection of molecular sequences, it can be convenient to reduce the number of sequences under consideration while maintaining some characteristic of a larger collection of sequences. For example, one may…

种群与进化 · 定量生物学 2012-09-03 Frederick A. Matsen , Aaron Gallagher , Connor McCoy

We analyse a maximum-likelihood approach for combining phylogenetic trees into a larger `supertree'. This is based on a simple exponential model of phylogenetic error, which ensures that ML supertrees have a simple combinatorial description…

种群与进化 · 定量生物学 2007-08-17 Mike Steel , Allen Rodrigo

The way to infer well-supported phylogenetic trees that precisely reflect the evolutionary process is a challenging task that completely depends on the way the related core genes have been found. In previous computational biology studies,…

Complexity metrics and machine learning (ML) models have been utilized to analyze the lengths of segmental genomic entities like: exons, introns, intergenic and repeat/unique DNA sequences, in each of the 22 human chromosomes. The purpose…

Sequence segmentation is a well-studied problem, where given a sequence of elements, an integer K, and some measure of homogeneity, the task is to split the sequence into K contiguous segments that are maximally homogeneous. A classic…

数据结构与算法 · 计算机科学 2019-02-12 Nikolaj Tatti

The maximum agreement forest (MAF) problem in phylogenetics takes as input a set t >= 2 of binary phylogenetic trees T on the same set of taxa X. It asks for a partition of X into the smallest number of blocks such that the subtrees induced…

组合数学 · 数学 2026-03-23 Steven Kelk , Ruben Meuwese , Leo van Iersel

In this paper, we propose a dictionary screening method for embedding compression in text classification tasks. The key purpose of this method is to evaluate the importance of each keyword in the dictionary. To this end, we first train a…

计算与语言 · 计算机科学 2022-11-24 Jing Zhou , Xinru Jing , Muyu Liu , Hansheng Wang

In recent years the importance of finding a meaningful pattern from huge datasets has become more challenging. Data miners try to adopt innovative methods to face this problem by applying feature selection methods. In this paper we propose…

机器学习 · 计算机科学 2014-03-11 Mehdi Naseriparsa , Amir-masoud Bidgoli , Touraj Varaee

Object Categorization is a challenging problem, especially when the images have clutter background, occlusions or different lighting conditions. In the past, many descriptors have been proposed which aid object categorization even in such…

计算机视觉与模式识别 · 计算机科学 2016-04-13 Dinesh Govindaraj

Minimum spanning trees (MSTs) provide a convenient representation of datasets in numerous pattern recognition activities. Moreover, they are relatively fast to compute. In this paper, we quantify the extent to which they are meaningful in…

机器学习 · 统计学 2025-10-16 Marek Gagolewski , Anna Cena , Maciej Bartoszuk , Łukasz Brzozowski

Centered kernel alignment (CKA) is a popular metric for comparing representations, determining equivalence of networks, and neuroscience research. However, CKA does not account for the underlying manifold and relies on numerous heuristics…

机器学习 · 计算机科学 2025-10-28 Mohammad Tariqul Islam , Du Liu , Deblina Sarkar

Alignment of large genomic sequences is a fundamental task in computational genome analysis. Most methods for genomic alignment use high-scoring local alignments as {\em anchor points} to reduce the search space of the alignment procedure.…

基因组学 · 定量生物学 2017-03-28 Chris-Andre Leimeister , Thomas Dencker , Burkhard Morgenstern

Packing several characters into one computer word is a simple and natural way to compress the representation of a string and to speed up its processing. Exploiting this idea, we propose an index for a packed string, based on a {\em sparse…

数据结构与算法 · 计算机科学 2015-03-19 Roman Kolpakov , Gregory Kucherov , Tatiana Starikovskaya

We propose a novel architecture for Graph Neural Networks that is inspired by the idea behind Tree Kernels of measuring similarity between trees by taking into account their common substructures, named fragments. By imposing a series of…

计算与语言 · 计算机科学 2021-10-04 Federico Ruggeri , Marco Lippi , Paolo Torroni

Motivation: High throughput DNA sequencing (HTS) technologies generate an excessive number of small DNA segments -- called short reads -- that cause significant computational burden. To analyze the entire genome, each of the billions of…

基因组学 · 定量生物学 2020-09-29 Mohammed Alser , Hasan Hassan , Hongyi Xin , Oğuz Ergin , Onur Mutlu , Can Alkan

Decision trees have been a very popular class of predictive models for decades due to their interpretability and good performance on categorical features. However, they are not always robust and tend to overfit the data. Additionally, if…

机器学习 · 计算机科学 2019-08-14 Oktay Gunluk , Jayant Kalagnanam , Minhan Li , Matt Menickelly , Katya Scheinberg

The so-called matrix-element method (MEM) has long been used successfully as a classification tool in particle physics searches. In the presence of invisible final state particles, the traditional MEM typically assigns probabilities to an…

高能物理 - 唯象学 · 物理学 2019-08-26 Stefan von Buddenbrock , Olivier Mattelaer , Michael Spannowsky

With histograms as its foundation, we develop Categorical Exploratory Data Analysis (CEDA) under the extreme-$K$ sample problem, and illustrate its universal applicability through four 1D categorical datasets. Given a sizable $K$, CEDA's…

应用统计 · 统计学 2020-07-31 Elizabeth Chou , Catie McVey , Yin-Chen Hsieh , Sabrina Enriquez , Fushing Hsieh

Finite-context models (FCMs) are widely used for compressing symbolic sequences such as DNA, where predictive performance depends critically on the context length k and smoothing parameter {\alpha}. In practice, these hyperparameters are…

机器学习 · 统计学 2026-03-23 José Contente , Ana Martins , Armando J. Pinho , Sónia Gouveia

In this paper, we consider a concatenated coding based class of DNA storage codes in which the selected molecules are constrained to be taken from an ``inner'' codebook associated with the sequencing channel. This codebook is used in a…

信息论 · 计算机科学 2025-06-19 Yan Hao Ling , Jonathan Scarlett
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