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This paper considers the problem of semi-parametric proportional hazards model fitting for interval, left and right censored survival times. We adopt a more versatile penalized likelihood method to estimate the baseline hazard and the…

统计方法学 · 统计学 2019-04-16 Jun Ma , Dominique-Laurent Couturier , Stephane Heritier , Ian Marschner

In this paper we introduce a mixture cure model with a linear hazard rate regression model for the event times. Cure models are statistical models for event times that take into account that a fraction of the population might never…

统计理论 · 数学 2020-11-26 Emil Aas Stoltenberg

Interval censored data commonly arise in medical studies when the event time of interest is only known to lie within an interval. In the presence of a cure subgroup, conventional mixture cure models typically assume a logistic model for the…

统计方法学 · 统计学 2026-01-21 Xiaoru Huang , Tonghui Yu , Xiaoyu Liu

In survival analysis it often happens that some subjects under study do not experience the event of interest; they are considered to be `cured'. The population is thus a mixture of two subpopulations: the one of cured subjects, and the one…

统计理论 · 数学 2017-01-16 Valentin Patilea , Ingrid Van Keilegom

In many public health problems, an important goal is to identify the effect of some treatment/intervention on the risk of failure for the whole population. A marginal proportional hazards regression model is often used to analyze such an…

统计理论 · 数学 2007-06-13 Donglin Zeng

Hereby we propose a Bayesian method of estimation for the semiparametric Additive Hazards Model (AHM) from Survival Analysis under right-censoring. With this aim, we review the AHM revisiting the likelihood function, so as to comment on the…

统计方法学 · 统计学 2025-05-28 Enrique Ernesto Álvarez , Maximiliano Luis Riddick

Survival analysis is a statistical technique used to estimate the time until an event occurs. Although it is applied across a wide range of fields, adjusting for reporting delays under practical constraints remains a significant challenge…

机器学习 · 统计学 2025-10-27 Yuta Shikuri , Hironori Fujisawa

We propose a new likelihood-based approach for estimation, inference and variable selection for parametric cure regression models in time-to-event analysis under random right-censoring. In this context, it often happens that some subjects…

统计方法学 · 统计学 2020-07-17 Kevin Burke , Valentin Patilea

The mixture cure rate model is the most commonly used cure rate model in the literature. In the context of mixture cure rate model, the standard approach to model the effect of covariates on the cured or uncured probability is to use a…

统计方法学 · 统计学 2022-08-23 Suvra Pal , Yingwei Peng , Sandip Barui , Pei Wang

Interval-censored competing risks data arise when each study subject may experience an event or failure from one of several causes and the failure time is not observed exactly but rather known to lie in an interval between two successive…

统计方法学 · 统计学 2016-03-02 Lu Mao , D. Y. Lin , Donglin Zeng

Continuous-time multi-state survival models can be used to describe health-related processes over time. In the presence of interval-censored times for transitions between the living states, the likelihood is constructed using transition…

统计方法学 · 统计学 2017-03-24 Robson J. M. Machado , Ardo van den Hout

We consider generalized linear regression analysis with left-censored covariate due to the lower limit of detection. Complete case analysis by eliminating observations with values below limit of detection yields valid estimates for…

统计方法学 · 统计学 2014-12-09 Shengchun Kong , Bin Nan

In recent years, mixture cure models have gained increasing popularity in survival analysis as an alternative to the Cox proportional hazards model, particularly in settings where a subset of patients is considered cured. The proportional…

统计方法学 · 统计学 2025-12-10 Fatih Kızılaslan , Valeria Vitelli

This work studies the statistical properties of the maximum penalized likelihood approach in a semi-parametric framework. We recall the penalized likelihood approach for estimating a function and review some asymptotic results. We…

统计理论 · 数学 2014-01-31 Daniel Commenges , Jérémie Bureau , Hein Putter

We discuss the semiparametric modeling of mark-recapture-recovery data where the temporal and/or individual variation of model parameters is explained via covariates. Typically, in such analyses a fixed (or mixed) effects parametric model…

应用统计 · 统计学 2015-05-21 Théo Michelot , Roland Langrock , Thomas Kneib , Ruth King

Cure models have been developed as an alternative modelling approach to conventional survival analysis in order to account for the presence of cured subjects that will never experience the event of interest. Mixture cure models, which model…

统计方法学 · 统计学 2022-07-19 Eni Musta , Valentin Patilea , Ingrid Van Keilegom

The cause of failure in cohort studies that involve competing risks is frequently incompletely observed. To address this, several methods have been proposed for the semiparametric proportional cause-specific hazards model under a missing at…

统计方法学 · 统计学 2020-02-24 Giorgos Bakoyannis , Ying Zhang , Constantin T. Yiannoutsos

Prevalent cohort sampling is commonly used to study the natural history of a disease when the disease is rare or it usually takes a long time to observe the failure event. It is known, however, that the collected sample in this situation is…

统计方法学 · 统计学 2022-09-05 Omidali Aghababaei Jazi

Interval-censoring frequently occurs in studies of chronic diseases where disease status is inferred from intermittently collected biomarkers. Although many methods have been developed to analyze such data, they typically assume perfect…

统计方法学 · 统计学 2026-05-26 Yuhao Deng , Donglin Zeng , Yuanjia Wang

In survival analysis, the lifetime under study is not always observed. In certain applications, for some individuals, the value of the lifetime is only known to be smaller or larger than some random duration. This framework represent an…

统计理论 · 数学 2020-02-25 Laurent Bordes , Maria Carmen Pardo , Christian Paroissin , Valentin Patilea
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