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Social distancing has been the only effective way to contain the spread of an infectious disease prior to the availability of the pharmaceutical treatment. It can lower the infection rate of the disease at the economic cost. A pandemic…

应用统计 · 统计学 2020-12-07 Kexin Chen , Chi Seng Pun , Hoi Ying Wong

In this study, we present a new epidemiological model, with contamination from confirmed and unreported. We also compute equilibria and study their stability without intervention strategies. Optimal control theory has proven to be a…

种群与进化 · 定量生物学 2020-08-14 Fulgence Mansal , Mouhamadou A. M. T. Baldé , Alpha O. Bah

Forecasting disease spread is a critical tool to help public health officials design and plan public health interventions. However, the expected future state of an epidemic is not necessarily well defined as disease spread is inherently…

种群与进化 · 定量生物学 2026-05-05 Mariah C. Boudreau , Andrea J. Allen , Nicholas J. Roberts , Antoine Allard , Laurent Hébert-Dufresne

Early on during a pandemic, vaccine availability is limited, requiring prioritisation of different population groups. Evaluating vaccine allocation is therefore a crucial element of pandemics response. In the present work, we develop a…

By the end of 2021, COVID-19 had spread to over 230 countries, with over 5.4 million deaths. To contain its spread, many countries implemented non-pharmaceutical interventions, notably contact tracing and self-quarantine policies. However,…

种群与进化 · 定量生物学 2024-11-14 Jungwoo Kim , Taesik Lee

The recent pandemic emphasized the need to consider the role of human behavior in shaping epidemic dynamics. In particular, it is necessary to extend beyond the classical epidemiological structures to fully capture the interplay between the…

动力系统 · 数学 2025-01-22 Leah LeJeune , Navid Ghaffarzadegan , Lauren Childs , Omar Saucedo

Given multiple new COVID-19 variants are continuously emerging, non-pharmaceutical interventions are still primary control strategies to curb the further spread of coronavirus. However, implementing strict interventions over extended…

种群与进化 · 定量生物学 2022-03-01 Xiao Zhou , Xiaohu Zhang , Paolo Santi , Carlo Ratti

For practical reasons, many forecasts of case, hospitalization and death counts in the context of the current COVID-19 pandemic are issued in the form of central predictive intervals at various levels. This is also the case for the…

应用统计 · 统计学 2021-06-09 Johannes Bracher , Evan L. Ray , Tilmann Gneiting , Nicholas G. Reich

The COVID-19 pandemic has brought forth the importance of epidemic forecasting for decision makers in multiple domains, ranging from public health to the economy as a whole. While forecasting epidemic progression is frequently…

When a new infectious disease (or a new strain of an existing one) emerges, as in the recent COVID-19 pandemic, different types of mobility restrictions are considered to slow down or mitigate the spread of the disease. The measures to be…

物理与社会 · 物理学 2026-04-21 Jõao Gabriel Simões Delboni , Gabriel Fabricius

Network--based epidemic models that account for heterogeneous contact patterns are extensively used to predict and control the diffusion of infectious diseases. We use census and survey data to reconstruct a geo--referenced and…

社会与信息网络 · 计算机科学 2026-05-19 Alessandro Celestini , Francesca Colaiori , Stefano Guarino , Enrico Mastrostefano , Lena Rebecca Zastrow

In this paper we propose a macro-dynamic age-structured set-up for the analysis of epidemics/economic dynamics in continuous time. The resulting optimal control problem is reformulated in an infinite dimensional Hilbert space framework…

理论经济学 · 经济学 2020-08-18 Giorgio Fabbri , Fausto Gozzi , Giovanni Zanco

Non-pharmaceutical interventions (NPIs) are crucial for controlling pandemics, but existing research often overlooks the heterogeneity of individual behavior, which can lead to inaccurate evaluations of the effectiveness of strategies. In…

物理与社会 · 物理学 2026-03-09 Xihan Zhang , Yuqing Liu , Chen Zhao , Guijun Li

We present a local spread model of disease transmission on a regular network and compare different control options ranging from treating the whole population to local control in a well-defined neighborhood of an infectious individual.…

生物物理 · 物理学 2015-05-30 Katarzyna Oles , Ewa Gudowska-Nowak , Adam Kleczkowski

To mitigate the impact of the pandemic, several measures include lockdowns, rapid vaccination programs, school closures, and economic stimulus. These interventions can have positive or unintended negative consequences. Current research to…

机器学习 · 计算机科学 2025-08-11 Gaurav Deshkar , Jayanta Kshirsagar , Harshal Hayatnagarkar , Janani Venugopalan

The impact of mitigation or control measures on an epidemics can be estimated by fitting the parameters of a compartmental model to empirical data, and running the model forward with modified parameters that account for a specific measure.…

种群与进化 · 定量生物学 2020-04-10 Jacopo Grilli , Matteo Marsili , Guido Sanguinetti

The paper introduces an approach to identify a set of spatially constrained homogeneous areas maximally homogeneous in terms of epidemic trends. The proposed hierarchical algorithm is based on the Dynamic TimeWarping distances between…

应用统计 · 统计学 2020-06-08 Roberto Benedetti , Federica Piersimoni , Giacomo Pignataro , Francesco Vidoli

Mathematical models in ecology and epidemiology must be consistent with observed data in order to generate reliable knowledge and evidence-based policy. Metapopulation systems, which consist of a network of connected sub-populations, pose…

应用统计 · 统计学 2024-02-07 Jifan Li , Edward L. Ionides , Aaron A. King , Mercedes Pascual , Ning Ning

Motivated by the increasing number of COVID-19 cases that have been observed in many countries after the vaccination and relaxation of non-pharmaceutical interventions, we propose a mathematical model on time-varying networks for the spread…

动力系统 · 数学 2022-03-09 Kathinka Frieswijk , Lorenzo Zino , Ming Cao

Combating an epidemic entails finding a plan that describes when and how to apply different interventions, such as mask-wearing mandates, vaccinations, school or workplace closures. An optimal plan will curb an epidemic with minimal loss of…

机器学习 · 计算机科学 2023-06-08 Anh Mai , Nikunj Gupta , Azza Abouzied , Dennis Shasha