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Effective vaccine prioritization is critical for epidemic control, yet real outbreaks exhibit memory effects that inflate state space and make long-term prediction and optimization challenging. As a result, many strategies are tuned to…

生物物理 · 物理学 2025-11-11 Mi Feng , Liang Tian , Changsong Zhou

Stochastic Model Predictive Control addresses uncertainties by incorporating chance constraints that provide probabilistic guarantees of constraint satisfaction. However, simultaneously optimizing over the risk allocation and the feedback…

系统与控制 · 电气工程与系统科学 2026-04-07 Filipe Marques Barbosa , Johan Löfberg

Clinical decision-making is a feedback system where risk estimates influence treatment, which in turn changes disease trajectories, and both shape clinicians' measurement practices. Static prediction often fails clinically: models trained…

The use of discretized variables in the development of prediction models is a common practice, in part because the decision-making process is more natural when it is based on rules created from segmented models. Although this practice is…

统计方法学 · 统计学 2024-03-19 Irantzu Barrio , Javier Roca-Pardiñas , Cristobal Esteban , Maria Durban

The optimal allocation of vaccines to population subgroups over time is a challenging health care management problem. In the context of a pandemic, the interaction between vaccination policies adopted by multiple agents and the cooperation…

最优化与控制 · 数学 2021-09-22 David Rey , Ahmed W Hammad , Meead Saberi

We consider the problem of optimizing locations of distribution centers (DCs) and plans for distributing resources such as test kits and vaccines, under spatiotemporal uncertainties of disease spread and demand for the resources. We aim to…

最优化与控制 · 数学 2022-07-19 Beste Basciftci , Xian Yu , Siqian Shen

This paper addresses a novel data science problem, prescriptive price optimization, which derives the optimal price strategy to maximize future profit/revenue on the basis of massive predictive formulas produced by machine learning. The…

最优化与控制 · 数学 2016-05-25 Shinji Ito , Ryohei Fujimaki

Stochastic optimization problems often involve data distributions that change in reaction to the decision variables. This is the case for example when members of the population respond to a deployed classifier by manipulating their features…

最优化与控制 · 数学 2020-12-15 Dmitriy Drusvyatskiy , Lin Xiao

Prediction models for clinical outcomes may be developed using a source dataset and additionally applied to new settings. Towards model external validation and model updating in the new setting, one procedure is model modification learning…

统计方法学 · 统计学 2020-12-01 W Katherine Tan , Patrick J Heagerty

Human decision-making differs due to variation in both incentives and available information. This constitutes a substantial challenge for the evaluation of whether and how machine learning predictions can improve decision outcomes. We…

综合经济学 · 经济学 2020-11-24 Michael Allan Ribers , Hannes Ullrich

We investigate the Susceptible-Infectious-Recovered contagion dynamics in a system of self-propelled particles with polar alignment. Using agent-based simulations, we analyze the outbreak process for different combinations of the spatial…

适应与自组织系统 · 物理学 2021-06-16 Yinong Zhao , Cristián Huepe , Pawel Romanczuk

To forecast the time dynamics of an epidemic, we propose a discrete stochastic model that unifies and generalizes previous approaches to the subject. Viewing a given population of individuals or groups of individuals with given health state…

Time-varying stochastic optimization problems frequently arise in machine learning practice (e.g. gradual domain shift, object tracking, strategic classification). Although most problems are solved in discrete time, the underlying process…

机器学习 · 计算机科学 2023-02-24 Subha Maity , Debarghya Mukherjee , Moulinath Banerjee , Yuekai Sun

We present a novel data-driven distributionally robust Model Predictive Control formulation for unknown discrete-time linear time-invariant systems affected by unknown and possibly unbounded additive uncertainties. We use off-line collected…

最优化与控制 · 数学 2022-09-20 Francesco Micheli , Tyler Summers , John Lygeros

We develop a stochastic two-patch epidemic model with nonlinear recidivism to investigate infectious disease dynamics in heterogeneous populations. Extending a deterministic framework, we introduce stochasticity to account for random…

种群与进化 · 定量生物学 2024-05-21 Juan G. Calvo , Mario I. Simoy , Juan P. Aparicio , José E. Chacón , Fabio Sanchez

Individual-based models of contagious processes are useful for predicting epidemic trajectories and informing intervention strategies. In such models, the incorporation of contact network information can capture the non-randomness and…

种群与进化 · 定量生物学 2023-11-09 Maxwell H. Wang , Jukka-Pekka Onnela

We propose a novel distribution-free scheme to solve optimization problems where the goal is to minimize the expected value of a cost function subject to probabilistic constraints. Unlike standard sampling-based methods, our idea consists…

最优化与控制 · 数学 2025-05-28 Francesco Cordiano , Matin Jafarian , Bart De Schutter

Vaccination has been proven to be the most effective method to prevent infectious diseases. However, in many low and middle-income countries with geographically dispersed and nomadic populations, last-mile vaccine delivery can be extremely…

应用统计 · 统计学 2021-04-30 Yuwen Yang , Jayant Rajgopal

Decision-making problems often feature uncertainty stemming from heterogeneous and context-dependent human preferences. To address this, we propose a sequential learning-and-optimization pipeline to learn preference distributions and…

机器学习 · 计算机科学 2026-03-19 Benjamin Hudson , Laurent Charlin , Emma Frejinger

This monograph provides an overview of the mathematical theories and computational algorithm design for contagion source detection in large networks. By leveraging network centrality as a tool for statistical inference, we can accurately…

社会与信息网络 · 计算机科学 2023-07-11 Chee Wei Tan , Pei-Duo Yu