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Network analysis is rapidly becoming a standard tool for studying functional magnetic resonance imaging (fMRI) data. In this framework, different brain areas are mapped to the nodes of a network, whose links depict functional dependencies…

神经元与认知 · 定量生物学 2017-05-30 Rainer Kujala , Enrico Glerean , Raj Kumar Pan , Iiro P. Jääskeläinen , Mikko Sams , Jari Saramäki

In many systems we can describe emergent macroscopic behaviors, quantitatively, using models that are much simpler than the underlying microscopic interactions; we understand the success of this simplification through the renormalization…

生物物理 · 物理学 2019-01-01 Leenoy Meshulam , Jeffrey L. Gauthier , Carlos D. Brody , David W. Tank , William Bialek

We develop a phenomenological coarse--graining procedure for activity in a large network of neurons, and apply this to recordings from a population of 1000+ cells in the hippocampus. Distributions of coarse--grained variables seem to…

神经元与认知 · 定量生物学 2019-10-30 Leenoy Meshulam , Jeffrey L. Gauthier , Carlos D. Brody , David W. Tank , William Bialek

We explore a systematic approach to studying the dynamics of evolving networks at a coarse-grained, system level. We emphasize the importance of finding good observables (network properties) in terms of which coarse grained models can be…

The human brain is a complex system, and understanding its mechanisms has been a long-standing challenge in neuroscience. The study of the functional connectome, which maps the functional connections between different brain regions, has…

神经与进化计算 · 计算机科学 2025-04-14 Tananun Songdechakraiwut , Yutong Wu

We propose a degree-based coarse graining approach that not just accelerates the evaluation of dynamics on complex networks, but also satisfies the consistency conditions for both equilibrium statistical distributions and nonequilibrium…

统计力学 · 物理学 2010-08-06 Hanshuang Chen , Zhonghuai Hou , Houwen Xin , YiJing Yan

Can complex engineered and biological networks be coarse-grained into smaller and more understandable versions in which each node represents an entire pattern in the original network? To address this, we define coarse-graining units (CGU)…

分子网络 · 定量生物学 2009-11-10 Shalev Itzkovitz , Reuven Levitt , Nadav Kashtan , Ron Milo , Michael Itzkovitz , Uri Alon

Finding accurate reduced descriptions for large, complex, dynamically evolving networks is a crucial enabler to their simulation, analysis, and, ultimately, design. Here we propose and illustrate a systematic and powerful approach to…

混沌动力学 · 物理学 2017-05-02 Tom Bertalan , Yan Wu , Carlo Laing , C. William Gear , Ioannis G. Kevrekidis

The human brain is the most complex object of study we encounter today. Mapping the neuronal-level connections between the more than 80 billion neurons in the brain is a hopeless task for science. By the recent advancement of magnetic…

神经元与认知 · 定量生物学 2020-09-01 Balint Varga , Vince Grolmusz

Human brain connectome studies aim at extracting and analyzing relevant features associated to pathologies of interest. Usually this consists in modeling the brain connectome as a graph and in using graph metrics as features. A fine brain…

Connectomics and network neuroscience offer quantitative scientific frameworks for modeling and analyzing networks of structurally and functionally interacting neurons, neuronal populations, and macroscopic brain areas. This shift in…

神经元与认知 · 定量生物学 2020-10-06 Richard Betzel

The ability to control complex networks is of crucial importance across a wide range of applications in natural and engineering sciences. However, issues of both theoretical and numerical nature introduce fundamental limitations to…

系统与控制 · 电气工程与系统科学 2023-12-13 Daniele Toller , Mirco Tribastone , Max Tschaikowski , Andrea Vandin

Novel computing hardwares are necessary to keep up with today's increasing demand for data storage and processing power. In this research project, we turn to the brain for inspiration to develop novel computing substrates that are…

Coarse-graining is a molecular modeling technique in which an atomistic system is represented in a simplified fashion that retains the most significant system features that contribute to a target output, while removing the degrees of…

Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

神经元与认知 · 定量生物学 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

机器学习 · 计算机科学 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

As more connectome data become available, the question of how to best analyse the structure of biological neural networks becomes increasingly pertinent. In brain networks, knowing that two areas are connected is often not sufficient, as…

神经元与认知 · 定量生物学 2024-01-30 Tanguy Fardet , Emmanouil Giannakakis , Lukas Paulun , Anna Levina

We tackle classification based on brain connectivity derived from diffusion magnetic resonance images. We propose a machine-learning model inspired by graph convolutional networks (GCNs), which takes a brain connectivity input graph and…

神经元与认知 · 定量生物学 2023-09-21 Anees Kazi , Jocelyn Mora , Bruce Fischl , Adrian V. Dalca , Iman Aganj

Finding the common structural brain connectivity network for a given population is an open problem, crucial for current neuro-science. Recent evidence suggests there's a tightly connected network shared between humans. Obtaining this…

神经元与认知 · 定量生物学 2017-01-10 Nahuel Lascano , Guillermo Gallardo , Rachid Deriche , Dorian Mazauric , Demian Wassermann

Large-scale white matter pathways crisscrossing the cortex create a complex pattern of connectivity that underlies human cognitive function. Generative mechanisms for this architecture have been difficult to identify in part because little…

神经元与认知 · 定量生物学 2015-06-16 Florian Klimm , Danielle S. Bassett , Jean M. Carlson , Peter J. Mucha
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