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Proteins in photosynthetic membranes can organize into patterned arrays that span the membrane's lateral size. Attractions between proteins in different layers of a membrane stack can play a key role in this ordering, as was suggested by…

软凝聚态物质 · 物理学 2020-09-09 Andreana M. Rosnik , Phillip L. Geissler

Twisted marine cables on the sea floor can form highly contorted three-dimensional loops that resemble tangles. Such tangles or hockles are topologically equivalent to the plectomenes that form in supercoiled DNA molecules. The dynamic…

数学物理 · 物理学 2015-06-26 Sachin Goyal , N. C. Perkins , Christopher L. Lee

Graph are a ubiquitous data representation, as they represent a flexible and compact representation. For instance, the 3D structure of RNA can be efficiently represented as $\textit{2.5D graphs}$, graphs whose nodes are nucleotides and…

机器学习 · 计算机科学 2021-09-21 Vincent Mallet , Carlos G. Oliver , William L. Hamilton

Filamentous bio-materials such as fibrin or collagen networks exhibit an enormous stiffening of their elastic moduli upon large deformations. This pronounced nonlinear behavior stems from a significant separation between the stiffnesses…

软凝聚态物质 · 物理学 2019-05-21 Robbie Rens , Carlos Villarroel , Gustavo Düring , Edan Lerner

Studies of circular DNA confined to nanofluidic channels are relevant both from a fundamental polymer-physics perspective and due to the importance of circular DNA molecules in vivo. We here observe the unfolding of DNA from the circular to…

We present techniques for speeding up the test-time evaluation of large convolutional networks, designed for object recognition tasks. These models deliver impressive accuracy but each image evaluation requires millions of floating point…

计算机视觉与模式识别 · 计算机科学 2024-03-15 Remi Denton , Wojciech Zaremba , Joan Bruna , Yann LeCun , Rob Fergus

Tip-driven growth processes underlie the development of many plants. To date, tip-driven growth processes have been modelled as an elongating path or series of segments without taking into account lateral expansion during elongation.…

生物物理 · 物理学 2014-01-24 Alexander Bucksch , Greg Turk , Joshua S. Weitz

We consider a class of random, weighted networks, obtained through a redefinition of patterns in an Hopfield-like model and, by performing percolation processes, we get information about topology and resilience properties of the networks…

统计力学 · 物理学 2015-05-30 Elena Agliari , Claudia Cioli , Enore Guadagnini

Translocation of DNA through a nanopore with embedded electrodes is at the centre of new rapid inexpensive sequencing methods which allow distinguishing the four nucleobases by their different electronic structure. However, the subnanometer…

介观与纳米尺度物理 · 物理学 2012-06-20 Yuhui He , Makusu Tsutsui , Ralph H. Scheicher , Masateru Taniguchi , Tomoji Kawai

We analyze the nonlinear waves that propagate on a microtubule that is tethered at its minus end due to kinesin walking on it, as is seen during the fluid mixing caused by cytoplasmic streaming in Drosophila oocytes.The model we use assumes…

生物大分子 · 定量生物学 2012-07-11 J. M. Deutsch , M. E. Brunner , William M. Saxton

Biological information is not only stored in the digital chemical sequence of double helical DNA, but is also encoded in the mechanical properties of the DNA strands, which can influence biochemical processes involving its readout. For…

软凝聚态物质 · 物理学 2015-06-10 Christian Matek , Thomas E. Ouldridge , Jonathan P. K. Doye , Ard A. Louis

The intercalation of metals beneath graphene offers a powerful route to stabilizing and protecting novel two-dimensional (2D) phases. The epitaxial growth of Pb monolayers on SiC(0001), combined with the relatively large spacing of the…

Many biological tissues feature a heterogeneous network of fibers whose tensile and bending rigidity contribute substantially to these tissues' elastic properties. Rigidity percolation has emerged as a important paradigm for relating these…

We present a numerically efficient method to reconstruct a disordered network of thin biopolymers, such as collagen gels, from three-dimensional (3D) image stacks recorded with a confocal microscope. Our method is based on a template…

定量方法 · 定量生物学 2011-11-17 Patrick Krauss , Claus Metzner , Janina Lange , Nadine Lang , Ben Fabry

We consider the folding of a self-avoiding homopolymer on a lattice, with saturating hydrogen bond interactions. Our goal is to numerically evaluate the statistical distribution of the topological genus of pseudoknotted configurations. The…

生物大分子 · 定量生物学 2009-11-11 G. Vernizzi , P. Ribeca , H. Orland , A. Zee

Phylogenetic networks are notoriously difficult to reconstruct. Here we suggest that it can be useful to view unknown genetic distance along edges in phylogenetic networks as analogous to unknown resistance in electric circuits. This…

组合数学 · 数学 2020-10-01 Stefan Forcey , Drew Scalzo

We report an alternative method for electrophoretic separation of large DNAs using steric confinement between solid walls, without gel or obstacles. The change of electrophoretic mobility vs confinement thickness is investigated using…

软凝聚态物质 · 物理学 2011-11-09 Jérôme Mathé , Jean-Marc Di Meglio , Bernard Tinland

Liquid crystal networks exploit the coupling between the responsivity of liquid-crystalline mesogens, e.g., to electric fields, and the (visco)elastic properties of a polymer network. Because of this, these materials have been put forward…

软凝聚态物质 · 物理学 2021-12-01 Guido L. A. Kusters , Nicholas B. Tito , Cornelis Storm , Paul van der Schoot

Tomography is a widely used tool for analyzing microstructures in three dimensions (3D). The analysis, however, faces difficulty because the constituent materials produce similar grey-scale values. Sometimes, this prompts the image…

材料科学 · 物理学 2021-09-28 Anand V. Patel , Tao Hou , Juan D. Beltran Rodriguez , Tamal K. Dey , Dunbar P. Birnie

A deep learning model is employed to address the challenging problem of V2O5 nanoparticle segmentation and the correlation between the chemical composition and the geometrical features of lithiated V2O5 nanoparticles as an exemplar of a…