相关论文: Physiological accuracy in simulating refractory ca…
The Extracellular-Membrane-Intracellular (EMI) model is a novel mathematical framework for cardiac electrophysiology simulations. The EMI model provides a more detailed description of the heart's electrical activity compared to traditional…
We propose a boundary element method for the accurate solution of the cell-by-cell bidomain model of electrophysiology. The cell-by-cell model, also called Extracellular-Membrane-Intracellular (EMI) model, is a system of reaction-diffusion…
The numerical tools to simulate the bidomain model in cardiac electrophysiology are constantly developing due to the great clinical interest and scientific advances in mathematical models and computational power. The bidomain model consists…
A model of the heart tissue as a conductive system with two interacting pacemakers and a refractory time, is proposed. In the parametric space of the model the phase locking areas are investigated in detail. Obtained results allow us to…
Computer-based simulations of non-invasive cardiac electrical outputs, such as electrocardiograms and body surface potential maps, usually entail severe computational costs due to the need of capturing fine-scale processes and to the…
Computer models of cardiac electro-mechanics (EM) show promise as an effective means for quantitative analysis of clinical data and, potentially, for predicting therapeutic responses.realize such advanced applications methodological key…
Precision cardiology based on cardiac digital twins requires accurate simulations of cardiac arrhythmias. However, detailed models, such as the monodomain model, are computationally costly and have limited applicability in practice. Thus,…
This work presents a biventricular electromechanical human heart model that is comprehensive and clinically relevant, integrating a realistic 3D heart geometry with both systemic and pulmonary hemodynamics. The model uses a two-way…
The electrocardiogram (ECG) is used for diagnosis and risk stratification in myocardial infarction (MI). Women have a higher incidence of missed MI diagnosis and complications following infarction, and to address this we aim to provide…
Objective: The bidomain model and the finite element method are an established standard to mathematically describe cardiac electrophysiology, but are both suboptimal choices for fast and large-scale simulations due to high computational…
The 19-dimensional TP06 cardiac muscle cell model is reduced to a 17-dimensional version, which satisfies the required conditions for performing an analysis of its dynamics by means of bifurcation theory. The reformulated model is shown to…
Over the past decades, hemodynamics simulators have steadily evolved and have become tools of choice for studying cardiovascular systems in-silico. While such tools are routinely used to simulate whole-body hemodynamics from physiological…
The immersed boundary (IB) method is a mathematical framework for fluid-structure interaction problems (FSI) that was originally developed to simulate flows around heart valves. Direct comparison of FSI simulations around heart valves…
This work deals with the numerical solution of the monodomain and bidomain models of electrical activity of myocardial tissue. The bidomain model is a system consisting of a possibly degenerate parabolic PDE coupled with an elliptic PDE for…
Arrhythmias are potentially fatal disruptions to the normal heart rhythm, but their underlying dynamics is still poorly understood. Theoretical modeling is an important tool to fill this gap. Typical studies often employ detailed…
Cardiac magnetic resonance imaging (CMR) offers detailed evaluation of cardiac structure and function, but its limited accessibility restricts use to selected patient populations. In contrast, the electrocardiogram (ECG) is ubiquitous and…
The heart is a vital organ that relies on the orchestrated propagation of electrical stimuli to coordinate each heart beat. Abnormalities in the heart's electrical behaviour can be managed with a cardiac pacemaker. Recently, the closed-loop…
The numerical simulation of cardiac electrophysiology is a highly challenging problem in scientific computing. The Bidomain system is the most complete mathematical model of cardiac bioelectrical activity. It consists of an elliptic and a…
The electrocardiogram (ECG) is modulated by torso-heart anatomy, and this challenges patients' diagnosis and risk stratification. This study aims to quantify how torso-heart anatomical factors affect sex-differences in ECG biomarkers in…
Computational models are increasingly used for diagnosis and treatment of cardiovascular disease. To provide a quantitative hemodynamic understanding that can be effectively used in the clinic, it is crucial to quantify the variability in…