相关论文: PASSerRank: Prediction of Allosteric Sites with Le…

Allostery commonly refers to the mechanism that regulates protein activity through the binding of a molecule at a different, usually distal, site from the orthosteric site. The omnipresence of allosteric regulation in nature and its…

Learning-to-Rank (LTR) is a supervised machine learning approach that constructs models specifically designed to order a set of items or documents based on their relevance or importance to a given query or context. Despite significant…

Allosteric regulation is central to many biochemical processes. Allosteric sites provide a target to fine-tune protein activity, yet we lack computational methods to predict them. Here, we present an efficient graph-theoretical approach for…

Selecting the right drugs for the right patients is a primary goal of precision medicine. In this manuscript, we consider the problem of cancer drug selection in a learning-to-rank framework. We have formulated the cancer drug selection…

Learning-to-rank (LTR) is a class of supervised learning techniques that apply to ranking problems dealing with a large number of features. The popularity and widespread application of LTR models in prioritizing information in a variety of…

Learning to Rank (LTR) methods are vital in online economies, affecting users and item providers. Fairness in LTR models is crucial to allocate exposure proportionally to item relevance. Widely used deterministic LTR models can lead to…

Learning-to-rank (LTR) is a set of supervised machine learning algorithms that aim at generating optimal ranking order over a list of items. A lot of ranking models have been studied during the past decades. And most of them treat each…

Allostery, the phenomenon by which the perturbation of a molecule at one site alters its behavior at a remote functional site, enables control over biomolecular function. Allosteric modulation is a promising avenue for drug discovery and is…

Online learning to rank (OLTR) interactively learns to choose lists of items from a large collection based on certain click models that describe users' click behaviors. Most recent works for this problem focus on the stochastic environment…

Allostery is a form of protein regulation, where ligands that bind sites located apart from the active site can modify the activity of the protein. The molecular mechanisms of allostery have been extensively studied, because allosteric…

Learning to rank (LTR) is widely employed in web searches to prioritize pertinent webpages from retrieved content based on input queries. However, traditional LTR models encounter two principal obstacles that lead to suboptimal performance:…

Stochastic learning to rank (LTR) is a recent branch in the LTR field that concerns the optimization of probabilistic ranking models. Their probabilistic behavior enables certain ranking qualities that are impossible with deterministic…

The goal of unbiased learning to rank (ULTR) is to leverage implicit user feedback for optimizing learning-to-rank systems. Among existing solutions, automatic ULTR algorithms that jointly learn user bias models (i.e., propensity models)…

Online Learning to Rank (OLTR) optimises ranking models using implicit user feedback, such as clicks. Unlike traditional Learning to Rank (LTR) methods that rely on a static set of training data with relevance judgements to learn a ranking…

Learning to Rank (LTR) technique is ubiquitous in the Information Retrieval system nowadays, especially in the Search Ranking application. The query-item relevance labels typically used to train the ranking model are often noisy…

Learning to rank (LTR) plays a crucial role in various Information Retrieval (IR) tasks. Although supervised LTR methods based on fine-grained relevance labels (e.g., document-level annotations) have achieved significant success, their…

Conventional Learning-to-Rank (LTR) methods optimize the utility of the rankings to the users, but they are oblivious to their impact on the ranked items. However, there has been a growing understanding that the latter is important to…

Learning-to-rank (LTR) has become a key technology in E-commerce applications. Most existing LTR approaches follow a supervised learning paradigm from offline labeled data collected from the online system. However, it has been noticed that…

The last decade has seen a revolution in the theory and application of machine learning and pattern recognition. Through these advancements, variable ranking has emerged as an active and growing research area and it is now beginning to be…

Online learning to rank (OLTR) aims to learn a ranker directly from implicit feedback derived from users' interactions, such as clicks. Clicks however are a biased signal: specifically, top-ranked documents are likely to attract more clicks…