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Understanding how biomarker distributions evolve over time is a central challenge in digital health and chronic disease monitoring. In diabetes, changes in the distribution of glucose measurements can reveal patterns of disease progression…

机器学习 · 统计学 2026-03-26 Antonio Álvarez-López , Marcos Matabuena

Rapid changes in blood glucose levels can have severe and immediate health consequences, leading to the need to develop indices for assessing these rapid changes based on continuous glucose monitoring (CGM) data. We proposed a CGM index,…

Continuous Blood Glucose (CGM) monitors have revolutionized the ability of diabetics to manage their blood glucose, and paved the way for artificial pancreas systems. In this paper we augment CGM data with sensor input collected by a smart…

人机交互 · 计算机科学 2023-02-06 Sam Royston

Describing dynamic medical systems using machine learning is a challenging topic with a wide range of applications. In this work, the possibility of modeling the blood glucose level of diabetic patients purely on the basis of measured data…

机器学习 · 计算机科学 2023-03-10 David Jödicke , Daniel Parra , Gabriel Kronberger , Stephan Winkler

The Glucose-Insulin-Glucagon nonlinear model [1-4] accurately describes how the body responds to exogenously supplied insulin and glucagon in patients affected by Type I diabetes. Based on this model, we design infusion rates of either…

组织与器官 · 定量生物学 2019-06-19 Afroza Shirin , Fabio Della Rossa , Isaac Klickstein , John Russell , Francesco Sorrentino

Individualized therapy is driven forward by medical data analysis, which provides insight into the patient's context. In particular, for Type 1 Diabetes (T1D), which is an autoimmune disease, relationships between demographics, sensor data,…

信号处理 · 电气工程与系统科学 2026-04-23 Beyza Cinar , Maria Maleshkova

People with diabetes need insulin delivery to effectively manage their blood glucose levels, especially after meals, because their bodies either do not produce enough insulin or cannot fully utilize it. Accurate insulin delivery starts with…

系统与控制 · 电气工程与系统科学 2024-11-21 Hanyu Zeng , Hui Ji , Pengfei Zhou

Type 1 diabetes (T1D) is an autoimmune disease of the beta cells of the pancreas. The nonobese diabetic (NOD) mouse is a commonly used animal model, with roughly an 80% incidence rate of T1D among females. In 100% of NOD mice, macrophages…

组织与器官 · 定量生物学 2014-12-23 James R. Moore , Fred Adler

Background and objective: Hybrid automated insulin delivery (hAID) systems represent the most advanced therapy for type 1 diabetes (T1D). Current systems rely on linear or linearized models of glucose homeostasis, which may compromise…

系统与控制 · 电气工程与系统科学 2025-12-08 Vihangkumar V. Naik , Eleonora Manzoni , Clara Escorihuela-Altaba , Jose Garcia-Tirado

Modern treatments for Type 1 diabetes (T1D) use devices known as artificial pancreata (APs), which combine an insulin pump with a continuous glucose monitor (CGM) operating in a closed-loop manner to control blood glucose levels. In…

机器学习 · 计算机科学 2018-12-04 Matthew O'Kelly , Aman Sinha , Justin Norden , Hongseok Namkoong

Given the growing prevalence of diabetes, there has been significant interest in determining how diabetes affects instrumental daily functions, like driving. Complication of glucose control in diabetes includes hypoglycemic and…

Personal health devices can enable continuous monitoring of health parameters. However, the benefit of these devices is often directly related to the frequency of use. Therefore, adherence to personal health devices is critical. This paper…

计算机与社会 · 计算机科学 2020-06-11 Sudip Vhaduri , Temiloluwa Prioleau

Precise and timely forecasting of blood glucose levels is essential for effective diabetes management. While extensive research has been conducted on Type 1 diabetes mellitus, Type 2 diabetes mellitus (T2DM) presents unique challenges due…

计算工程、金融与科学 · 计算机科学 2024-09-12 Yuyang Sun , Panagiotis Kosmas

In the UK, approximately 400,000 people with type 1 diabetes (T1D) rely on insulin delivery due to insufficient pancreatic insulin production. Managing blood glucose (BG) levels is crucial, with continuous glucose monitoring (CGM) playing a…

机器学习 · 计算机科学 2023-12-21 Chengzhe Piao , Ken Li

The rapid growth in mobile healthcare technology could significantly help control chronic diseases, such as diabetes. This paper presents a systematic review to characterise type 1 & type 2 diabetes management applications available in…

计算机与社会 · 计算机科学 2019-04-23 Ahmed Fadhil , Yunlong Wang

The management of type 1 diabetes has been revolutionized by the artificial pancreas system (APS), which automates insulin delivery based on continuous glucose monitor (CGM). While conventional closed-loop systems rely on CGM data, which…

系统与控制 · 电气工程与系统科学 2024-11-19 Debayani Ghosh , Sahaj Saxena , Navin Kumar

Background: This study investigates glucose conditions preceding and following various hypoglycemia levels in individuals with type 1 diabetes using open-source automated insulin delivery (AID) systems. It also seeks to evaluate…

定量方法 · 定量生物学 2024-05-16 Arsalan Shahid , Dana M. Lewis

Type 1 diabetes (T1D) management can be significantly enhanced through the use of predictive machine learning (ML) algorithms, which can mitigate the risk of adverse events like hypoglycemia. Hypoglycemia, characterized by blood glucose…

定量方法 · 定量生物学 2025-04-02 Beyza Cinar , Jennifer Daniel Onwuchekwa , Maria Maleshkova

In this paper we investigate the use of model-based reinforcement learning to assist people with Type 1 Diabetes with insulin dose decisions. The proposed architecture consists of multiple Echo State Networks to predict blood glucose levels…

Despite the well-acknowledged benefits of physical activity for type 2 diabetes (T2D) prevention, the literature surprisingly lacks validated models able to predict the long-term benefits of exercise on T2D progression and support…

系统与控制 · 电气工程与系统科学 2024-04-24 Pierluigi Francesco De Paola , Alessandro Borri , Fabrizio Dabbene , Karim Keshavjee , Pasquale Palumbo , Alessia Paglialonga