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Phages are one of the most present groups of organisms in the biosphere. Their identification continues and their taxonomies are divergent. However, due to their evolution mode and the complexity of their species ecosystem, their…

种群与进化 · 定量生物学 2022-01-04 Dung Nguyen , Alix Boc , Abdoulaye Banire Diallo , Vladimir Makarenkov

Motivation: Bacteriophages are viruses infecting bacteria. Being key players in microbial communities, they can regulate the composition/function of microbiome by infecting their bacterial hosts and mediating gene transfer. Recently,…

基因组学 · 定量生物学 2022-08-15 Jiayu Shang , Xubo Tang , Ruocheng Guo , Yanni Sun

Bacteria and their bacteriophages are the most abundant, widespread and diverse groups of biological entities on the planet. In an attempt to understand how the interactions between bacteria, virulent phages and temperate phages might…

种群与进化 · 定量生物学 2009-11-13 Martin Rosvall , Ian B. Dodd , Sandeep Krishna , Kim Sneppen

Bacteriophages are viruses that target bacteria, playing a crucial role in microbial ecology. Phage proteins are important in understanding phage biology, such as virus infection, replication, and evolution. Although a large number of new…

定量方法 · 定量生物学 2024-08-20 Jiaojiao Guan , Yongxin Ji , Cheng Peng , Wei Zou , Xubo Tang , Jiayu Shang , Yanni Sun

Bacteriophages are viruses infecting bacteria and archaea. Many phage species cause infections which lead to the certain death of the infected prokaryotic host cell and the release of a large batch of phage progeny, yet they have been able…

种群与进化 · 定量生物学 2019-12-24 Matthias M. Fischer

Bacteriophages (phages) are key regulators of bacterial populations and hold great promise for applications such as phage therapy, biocontrol, and industrial fermentation. The success of these applications depends on accurately determining…

基因组学 · 定量生物学 2026-01-23 Yang Shen , Keming Shi , Chen Yu , Rui Zhang , Yanni Sun , Jiayu Shang

Bacteriophages are central to microbial ecosystems for balancing bacterial populations and promoting evolution by applying strong selection pressure. Here we review some of the known aspects that modulate phage-bacteria interaction in a way…

种群与进化 · 定量生物学 2023-04-12 Namiko Mitarai , Anastasios Marantos , Kim Sneppen

We present a new method for detecting and identifying bacteria by measuring impedance fluctuations (impedance noise) caused by ion release by the bacteria during phage infestation. This new method significantly increases the measured signal…

仪器与探测器 · 物理学 2014-07-22 Gabor Schmera , Laszlo B. Kish

The explosion in known microbial diversity in the last two decades has made it abundantly clear that microbes in the environment do not exist in isolation; they are members of communities. Accordingly, omics approaches such as metagenomics…

定量方法 · 定量生物学 2024-07-15 James C. Kosmopoulos , Karthik Anantharaman

Sequence differences between the strains of bacteria comprising host-associated and environmental microbiota may play a role in community assembly and influence the resilience of microbial communities to disturbances. Tools for…

Bacteria and their viruses ("bacteriophages") coexist in natural environments forming complex infection networks. Recent empirical findings suggest that phage-bacteria infection networks often possess a nested structure such that there is a…

种群与进化 · 定量生物学 2013-04-09 Luis F. Jover , Michael H. Cortez , Joshua S. Weitz

The term bacteriophage means killer or eater of bacteria. They were initially discovered by F.W. Twort and later on, Felix d'Herelle unveiled them to the world in 1910. Phage therapy has arisen as a favorable option to conventional…

Motivation: There is accumulating evidence showing the important roles of bacteriophages (phages) in regulating the structure and functions of the microbiome. However, lacking an easy-to-use and integrated phage analysis software hampers…

基因组学 · 定量生物学 2023-07-28 Jiayu Shang , Cheng Peng , Herui Liao , Xubo Tang , Yanni Sun

Bacteriophages (or phages), which infect bacteria, have two distinct lifestyles: virulent and temperate. Predicting the lifestyle of phages helps decipher their interactions with their bacterial hosts, aiding phages' applications in fields…

基因组学 · 定量生物学 2023-01-02 Jiayu Shang , Xubo Tang , Yanni Sun

While metagenomics has emerged as a technology of choice for analyzing bacterial populations, assembly of metagenomic data remains difficult thus stifling biological discoveries. metaSPAdes is a new assembler that addresses the challenge of…

基因组学 · 定量生物学 2016-08-02 Sergey Nurk , Dmitry Meleshko , Anton Korobeynikov , Pavel Pevzner

Microbes are essentially yet convolutedly linked with human lives on the earth. They critically interfere in different physiological processes and thus influence overall health status. Studying microbial species is used to be constrained to…

基因组学 · 定量生物学 2021-09-03 Chao Yang , Debajyoti Chowdhury , Zhenmiao Zhang , William K. Cheung , Aiping Lu , Zhao Xiang Bian , Lu Zhang

Identifying viral pathogens and characterizing their transmission is essential to developing effective public health measures in response to a pandemic. Phylogenetics, though currently the most popular tool used to characterize the likely…

定量方法 · 定量生物学 2015-05-28 Anil Raj , Michael Dewar , Gustavo Palacios , Raul Rabadan , Chris H. Wiggins

Bacteriophages, phages for short, are viruses of bacteria. The majority of phages contain a double-stranded DNA genome packaged in a capsid at a density of ~500 mg/ml. This high density requires substantial compression of the normal B form…

生物大分子 · 定量生物学 2010-12-13 Debabrata Panja , Ian J. Molineux

Advances in next-generation sequencing technology have enabled the high-throughput profiling of metagenomes and accelerated the microbiome study. Recently, there has been a rise in quantitative studies that aim to decipher the microbiome…

统计方法学 · 统计学 2023-08-29 Kevin C. Lutz , Michael L. Neugent , Tejasv Bedi , Nicole J. De Nisco , Qiwei Li

Bacterial heterogeneity is pivotal for adaptation to diverse environments, posing significant challenges in microbial diagnostics and therapeutic interventions. Recent advancements in high-resolution optical microscopy have revolutionized…

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