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The interpretation of count data originating from the current generation of DNA sequencing platforms requires special attention. In particular, the per-sample library sizes often vary by orders of magnitude from the same sequencing run, and…

定量方法 · 定量生物学 2015-06-17 Paul J. McMurdie , Susan Holmes

Despite the widespread utilization of Gaussian process models for versatile nonparametric modeling, they exhibit limitations in effectively capturing abrupt changes in function smoothness and accommodating relationships with heteroscedastic…

机器学习 · 统计学 2023-09-01 Taehee Lee , Jun S. Liu

Background: In the metagenome assembly of a microbiome community, we may think abundant species would be easier to assemble due to their deeper coverage. However, this conjucture is rarely tested. We often do not know how many abundant…

基因组学 · 定量生物学 2022-11-23 Xiaowen Feng , Heng Li

We propose a general modeling framework for marked Poisson processes observed over time or space. The modeling approach exploits the connection of the nonhomogeneous Poisson process intensity with a density function. Nonparametric Dirichlet…

统计方法学 · 统计学 2011-11-02 Matthew A. Taddy , Athanasios Kottas

In this paper, an alternative mixed Poisson distribution is proposed by amalgamating Poisson distribution and a modification of the Quasi Lindley distribution. Some fundamental structural properties of the new distribution, namely the shape…

统计方法学 · 统计学 2021-10-26 Ramajeyam Tharshan , Pushpakanthie Wijekoon

This short study presents an opportunistic approach to a (more) reliable validation method for prediction uncertainty average calibration. Considering that variance-based calibration metrics (ZMS, NLL, RCE...) are quite sensitive to the…

机器学习 · 统计学 2024-08-27 Pascal Pernot

The generalised linear model (GLM) is a very important tool for analysing real data in biology, sociology, agriculture, engineering and many other application domain where the relationship between the response and explanatory variables may…

统计方法学 · 统计学 2016-07-04 Abhik Ghosh , Ayanendranath Basu

Observational studies provide invaluable opportunities to draw causal inference, but they may suffer from biases due to pretreatment difference between treated and control units. Matching is a popular approach to reduce observed covariate…

统计方法学 · 统计学 2025-09-17 Xinran Li

The advent of high-throughput sequencing technologies has made data from DNA material readily available, leading to a surge of microbiome-related research establishing links between markers of microbiome health and specific outcomes.…

统计方法学 · 统计学 2018-06-19 Susheela P. Singh , Ana-Maria Staicu , Robert R. Dunn , Noah Fierer , Brian J. Reich

Classifier-free guidance (CFG) is the de facto standard for conditional sampling in diffusion models, yet it often reduces sample diversity. Using tools from statistical physics, we analyze the emergence of generative distortions induced by…

机器学习 · 统计学 2026-05-11 Enrico Ventura , Beatrice Achilli , Luca Ambrogioni , Carlo Lucibello

In a variety of application areas, there is a growing interest in analyzing high dimensional sparse count data, with sparsity exhibited by an over-abundance of zeros and small non-zero counts. Existing approaches for analyzing multivariate…

统计方法学 · 统计学 2016-04-15 Jyotishka Datta , David B. Dunson

Real-world networks are sparse. As we show in this article, even when a large number of interactions is observed, most node pairs remain disconnected. We demonstrate that classical multi-edge network models, such as the $G(N,p)$,…

社会与信息网络 · 计算机科学 2025-01-03 Giona Casiraghi , Georges Andres

Computer experiments with both quantitative and qualitative (QQ) inputs are commonly used in science and engineering applications. Constructing desirable emulators for such computer experiments remains a challenging problem. In this…

统计方法学 · 统计学 2022-03-22 Qian Xiao , Abhyuday Mandal , C. Devon Lin , Xinwei Deng

The assessment of diversity and similarity is relevant in monitoring the status of ecosystems. The respective indicators are based on the taxonomic composition of biological communities of interest, currently estimated through the…

应用统计 · 统计学 2018-10-12 Fabio Divino , Johanna Ärje , Antti Penttinen , Kristian Meissner , Salme Kärkkäinen

The latent position network model (LPM) is a popular approach for the statistical analysis of network data. A central aspect of this model is that it assigns nodes to random positions in a latent space, such that the probability of an…

统计方法学 · 统计学 2026-02-02 Chaoyi Lu , Riccardo Rastelli , Nial Friel

In the era of open data, Poisson and other count regression models are increasingly important. Still, conventional Poisson regression has remaining issues in terms of identifiability and computational efficiency. Especially, due to an…

统计方法学 · 统计学 2022-01-19 Daisuke Murakami , Tomoko Matsui

This paper presents a novel method for statistical inference in high-dimensional binary models with unspecified structure, where we leverage a (potentially misspecified) sparsity-constrained working generalized linear model (GLM) to…

统计方法学 · 统计学 2025-10-03 Xiaotian Hou , Peng Wang , Minge Xie , Linjun Zhang

This paper proposes a framework for multi-robot systems to perform simultaneous learning and coverage of a domain of interest characterized by an unknown and potentially time-varying density function. To overcome the limitations of Gaussian…

机器人学 · 计算机科学 2025-11-11 Ruijie Du , Ruoyu Lin , Yanning Shen , Magnus Egerstedt

Zero-shot diffusion posterior sampling offers a flexible framework for inverse problems by accommodating arbitrary degradation operators at test time, but incurs high computational cost due to repeated likelihood-guided updates. In…

机器学习 · 统计学 2026-02-10 Léon Zheng , Thomas Hirtz , Yazid Janati , Eric Moulines

Detecting multimodality in empirical distributions is a fundamental problem in statistics and data analysis, with applications ranging from clustering to the study of complex systems. In practice, however, assessing departures from…

统计方法学 · 统计学 2026-05-21 Edoardo Di Martino , Matteo Cinelli , Roy Cerqueti