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Adaptive designs have been proposed for clinical trials in which the nuisance parameters or alternative of interest are unknown or likely to be misspecified before the trial. Whereas most previous works on adaptive designs and mid-course…

统计方法学 · 统计学 2011-05-18 Jay Bartroff , Tze Leung Lai

By combining a standard symmetric, symplectic integrator with a new step size controller, we provide an integration scheme that is symmetric, reversible and conserves the values of the constants of motion. This new scheme is appropriate for…

广义相对论与量子宇宙学 · 物理学 2012-12-07 Jonathan Seyrich , Georgios Lukes-Gerakopoulos

The dynamics of cellular pattern formation is crucial for understanding embryonic development and tissue morphogenesis. Recent studies have shown that human dermal fibroblasts cultured on liquid crystal elastomers can exhibit an increase in…

生物物理 · 物理学 2023-08-25 Mengyang Gu , Xinyi Fang , Yimin Luo

In dynamic systems that adapt to users' needs and changing environments, dependability needs cannot be avoided. This paper proposes an orthogonal fault tolerance model as a means to manage and reason about multiple fault tolerance…

软件工程 · 计算机科学 2014-04-29 Sobia K Khan

Large-scale pre-trained language models such as BERT have contributed significantly to the development of NLP. However, those models require large computational resources, making it difficult to be applied to mobile devices where computing…

计算与语言 · 计算机科学 2023-08-02 Weixin Wu , Hankz Hankui Zhuo

The bootstrap is a widely used procedure for statistical inference because of its simplicity and attractive statistical properties. However, the vanilla version of bootstrap is no longer feasible computationally for many modern massive…

统计方法学 · 统计学 2023-02-16 Yingying Ma , Chenlei Leng , Hansheng Wang

We study the problem of efficient integration of variational equations in multi-dimensional Hamiltonian systems. For this purpose, we consider a Runge-Kutta-type integrator, a Taylor series expansion method and the so-called `Tangent Map'…

混沌动力学 · 物理学 2016-12-21 Enrico Gerlach , Siegfried Eggl , Charalampos Skokos

The difficulty of simulating quantum dynamics depends on the norm of the Hamiltonian. When the Hamiltonian varies with time, the simulation complexity should only depend on this quantity instantaneously. We develop quantum simulation…

量子物理 · 物理学 2020-04-21 Dominic W. Berry , Andrew M. Childs , Yuan Su , Xin Wang , Nathan Wiebe

After a brief review of the Fermi-Pasta-Ulam (FPU) conservative system of N nonlinearly coupled oscillators, this paper addresses two problems: first, comparing two indicators for the equipartition, showing that the results are essentially…

动力系统 · 数学 2015-04-30 Jacopo De Tullio

Large Language Models (LLMs) have revolutionized various domains but encounter substantial challenges in tackling optimization modeling tasks for Operations Research (OR), particularly when dealing with complex problem. In this work, we…

计算与语言 · 计算机科学 2025-06-24 Yang Wu , Yifan Zhang , Yurong Wu , Yuran Wang , Junkai Zhang , Jian Cheng

The application of kernel-based Machine Learning (ML) techniques to discrete choice modelling using large datasets often faces challenges due to memory requirements and the considerable number of parameters involved in these models. This…

We present two types of meta-algorithm that can greatly improve the accuracy of existing algorithms for integrating the equations of motion of dynamical systems. The first meta-algorithm takes an integrator that is time-symmetric only for…

天体物理学 · 物理学 2007-05-23 Piet Hut , Yoko Funato , Eiichiro Kokubo , Junichiro Makino , Steve McMillan

Hamiltonian Monte-Carlo (HMC) and its auto-tuned variant, the No U-Turn Sampler (NUTS) can struggle to accurately sample distributions with complex geometries, e.g., varying curvature, due to their constant step size for leapfrog…

统计计算 · 统计学 2024-10-30 Chirag Modi

In this paper, we introduce a novel high-dimensional Factor-Adjusted sparse Partially Linear regression Model (FAPLM), to integrate the linear effects of high-dimensional latent factors with the nonparametric effects of low-dimensional…

统计方法学 · 统计学 2025-01-14 Yanmei Shi , Meiling Hao , Yanlin Tang , Xu Guo

Statisticians increasingly face the problem to reconsider the adaptability of classical inference techniques. In particular, divers types of high-dimensional data structures are observed in various research areas; disclosing the boundaries…

统计理论 · 数学 2017-06-09 Paavo Sattler , Markus Pauly

In developing products for rare diseases, statistical challenges arise due to the limited number of patients available for participation in drug trials and other clinical research. Bayesian adaptive clinical trial designs offer the…

应用统计 · 统计学 2019-09-19 Xiao Wu , Yi Xu , Bradley P. Carlin

Discrete-state, continuous-time Markov models are widely used in the modeling of biochemical reaction networks. Their complexity often precludes analytic solution, and we rely on stochastic simulation algorithms to estimate system…

定量方法 · 定量生物学 2016-05-20 Christopher Lester , Christian A. Yates , Michael B. Giles , Ruth E. Baker

Selecting an effective step-size is a fundamental challenge in first-order optimization, especially for problems with non-Euclidean geometries. This paper presents a novel adaptive step-size strategy for optimization algorithms that rely on…

最优化与控制 · 数学 2025-10-14 Abbas Khademi , Antonio Silveti-Falls

Traditional step size controllers make the tacit assumption that the cost of a time step is independent of the step size. This is reasonable for explicit and implicit integrators that use direct solvers. In the context of exponential…

数值分析 · 数学 2022-08-18 Pranab Jyoti Deka , Lukas Einkemmer

Recent research on time-series self-supervised models shows great promise in learning semantic representations. However, it has been limited to small-scale datasets, e.g., thousands of temporal sequences. In this work, we make key technical…

机器学习 · 计算机科学 2024-07-11 Chenguo Lin , Xumeng Wen , Wei Cao , Congrui Huang , Jiang Bian , Stephen Lin , Zhirong Wu