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Alzheimer's disease (AD) is characterized by complex and largely unknown progression dynamics affecting the brain's morphology. Although the disease evolution spans decades, to date we cannot rely on long-term data to model the pathological…

应用统计 · 统计学 2019-08-14 Clement Abi Nader , Nicholas Ayache , Philippe Robert , Marco Lorenzi

The uncertainty of clinical examinations frequently leads to irregular observation intervals in longitudinal imaging data, posing challenges for modeling disease progression.Most existing imaging-based disease prediction models operate in…

计算机视觉与模式识别 · 计算机科学 2025-11-26 Xin Hong , Ying Shi , Yinhao Li , Yen-Wei Chen

Alzheimer's disease (AD) is an irreversible devastative neurodegenerative disorder associated with progressive impairment of memory and cognitive functions. Its early diagnosis is crucial for the development of possible future treatment…

计算机视觉与模式识别 · 计算机科学 2020-04-07 Ahsan Bin Tufail , Qiu-Na Zhang , Yong-Kui Ma

Although Transformers excel in natural language processing, their extension to time series forecasting remains challenging due to insufficient consideration of the differences between textual and temporal modalities. In this paper, we…

机器学习 · 计算机科学 2025-10-09 Zhipeng Liu , Peibo Duan , Xuan Tang , Baixin Li , Yongsheng Huang , Mingyang Geng , Changsheng Zhang , Bin Zhang , Binwu Wang

Deep learning (DL) for predicting Alzheimer's disease (AD) has provided timely intervention in disease progression yet still demands attentive interpretability to explain how their DL models make definitive decisions. Recently,…

人工智能 · 计算机科学 2023-10-06 Kwanseok Oh , Da-Woon Heo , Ahmad Wisnu Mulyadi , Wonsik Jung , Eunsong Kang , Kun Ho Lee , Heung-Il Suk

Glaucoma is one of the major eye diseases that leads to progressive optic nerve fiber damage and irreversible blindness, afflicting millions of individuals. Glaucoma forecast is a good solution to early screening and intervention of…

计算机视觉与模式识别 · 计算机科学 2024-02-22 Xikai Yang , Jian Wu , Xi Wang , Yuchen Yuan , Ning Li Wang , Pheng-Ann Heng

Transfer learning has been widely utilized to mitigate the data scarcity problem in the field of Alzheimer's disease (AD). Conventional transfer learning relies on re-using models trained on AD-irrelevant tasks such as natural image…

图像与视频处理 · 电气工程与系统科学 2023-04-18 Kai Tzu-iunn Ong , Hana Kim , Minjin Kim , Jinseong Jang , Beomseok Sohn , Yoon Seong Choi , Dosik Hwang , Seong Jae Hwang , Jinyoung Yeo

Generative approaches for cross-modality transformation have recently gained significant attention in neuroimaging. While most previous work has focused on case-control data, the application of generative models to disorder-specific…

神经元与认知 · 定量生物学 2024-05-10 Reihaneh Hassanzadeh , Anees Abrol , Hamid Reza Hassanzadeh , Vince D. Calhoun

Alzheimer's Disease (AD) is marked by significant inter-individual variability in its progression, complicating accurate prognosis and personalized care planning. This heterogeneity underscores the critical need for predictive models…

机器学习 · 计算机科学 2025-05-01 Gulsah Hancerliogullari Koksalmis , Bulent Soykan , Laura J. Brattain , Hsin-Hsiung Huang

Objectives: The objectives of this narrative review are to summarize the current state of AI applications in neuroimaging for early Alzheimer's disease (AD) prediction and to highlight the potential of AI techniques in improving early AD…

机器学习 · 计算机科学 2024-06-27 Thorsten Rudroff , Oona Rainio , Riku Klén

Predicting individual cognitive decline in Alzheimer's disease (AD) is difficult due to the heterogeneity of disease progression. Reliable clinical tools require not only high accuracy but also fairness across demographics and robustness to…

人工智能 · 计算机科学 2026-04-27 Bulent Soykan , Gulsah Hancerliogullari Koksalmis , Hsin-Hsiung Huang , Laura J. Brattain

Alzheimer's disease (AD) is associated with local (e.g. brain tissue atrophy) and global brain changes (loss of cerebral connectivity), which can be detected by high-resolution structural magnetic resonance imaging. Conventionally, these…

机器学习 · 计算机科学 2021-05-11 Sarah C. Brüningk , Felix Hensel , Catherine R. Jutzeler , Bastian Rieck

Generative AI framework-based modeling and prediction of longitudinal human brain images offer an efficient mechanism to track neurodegenerative progression, essential for the assessment of diseases like Alzheimer's. Among the existing…

计算机视觉与模式识别 · 计算机科学 2026-03-03 Ayantika Das , Keerthi Ram , Mohanasankar Sivaprakasam

Predicting the risk of clinical progression from cognitively normal (CN) status to mild cognitive impairment (MCI) or Alzheimer's disease (AD) is critical for early intervention in Alzheimer's disease (AD). Traditional survival models often…

应用统计 · 统计学 2025-03-24 Dhrubajyoti Ghosh , Samhita Pal , Michael Lutz , Sheng Luo

Human Activity Recognition (HAR) using wearable sensor data has become a central task in mobile computing, healthcare, and human-computer interaction. Despite the success of traditional deep learning models such as CNNs and RNNs, they often…

机器学习 · 计算机科学 2025-05-27 Yunbo Liu , Xukui Qin , Yifan Gao , Xiang Li , Chengwei Feng

Understanding complex animal behaviors hinges on deciphering the neural activity patterns within brain circuits, making the ability to forecast neural activity crucial for developing predictive models of brain dynamics. This capability…

The performance of time series forecasting has recently been greatly improved by the introduction of transformers. In this paper, we propose a general multi-scale framework that can be applied to the state-of-the-art transformer-based time…

机器学习 · 计算机科学 2023-02-08 Amin Shabani , Amir Abdi , Lili Meng , Tristan Sylvain

Disease progression modeling (DPM) using longitudinal data is a challenging machine learning task. Existing DPM algorithms neglect temporal dependencies among measurements, make parametric assumptions about biomarker trajectories, do not…

计算机视觉与模式识别 · 计算机科学 2019-03-19 Mostafa Mehdipour Ghazi , Mads Nielsen , Akshay Pai , M. Jorge Cardoso , Marc Modat , Sebastien Ourselin , Lauge Sørensen

Deep Neural Networks - especially Convolutional Neural Network (ConvNet) has become the state-of-the-art for image classification, pattern recognition and various computer vision tasks. ConvNet has a huge potential in medical domain for…

计算机视觉与模式识别 · 计算机科学 2020-09-11 Md Motiur Rahman Sagar , Martin Dyrba

Alzheimer's Disease (AD) is one of the most concerned neurodegenerative diseases. In the last decade, studies on AD diagnosis attached great significance to artificial intelligence (AI)-based diagnostic algorithms. Among the diverse…

计算机视觉与模式识别 · 计算机科学 2019-08-20 Yechong Huang , Jiahang Xu , Yuncheng Zhou , Tong Tong , Xiahai Zhuang , the Alzheimer's Disease Neuroimaging Initiative