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Alzheimer's Dementia (AD) is a progressive neurodegenerative disease marked by irreversible decline, making reliable modeling of its progression essential for effective patient care. Progression-aware methods such as survival analysis are…
Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot…
Time-series forecasts are essential for planning and decision-making in many domains. Explainability is key to building user trust and meeting transparency requirements. Shapley Additive Explanations (SHAP) is a popular explainable AI…
Time-series forecasting plays an important role in many real-world scenarios, such as equipment life cycle forecasting, weather forecasting, and traffic flow forecasting. It can be observed from recent research that a variety of…
Predicting the future movements of surrounding vehicles is essential for ensuring the safe operation and efficient navigation of autonomous vehicles (AVs) in urban traffic environments. Existing vehicle trajectory prediction methods…
Although Transformer-based methods have significantly improved state-of-the-art results for long-term series forecasting, they are not only computationally expensive but more importantly, are unable to capture the global view of time series…
Computer-aided early diagnosis of Alzheimer's disease (AD) and its prodromal form mild cognitive impairment (MCI) based on structure Magnetic Resonance Imaging (sMRI) has provided a cost-effective and objective way for early prevention and…
Accurate modeling of cognitive decline in Alzheimer's disease is essential for early stratification and personalized management. While tabular predictors provide robust markers of global risk, their ability to capture subtle brain changes…
The analysis of long sequence data remains challenging in many real-world applications. We propose a novel architecture, ChunkFormer, that improves the existing Transformer framework to handle the challenges while dealing with long time…
Early detection of Alzheimer's Disease (AD) and its prodromal state, Mild Cognitive Impairment (MCI), is crucial for providing suitable treatment and preventing the disease from progressing. It can also aid researchers and clinicians to…
Normative modeling has emerged as a pivotal approach for characterizing heterogeneity and individual variance in neurodegenerative diseases, notably Alzheimer's disease(AD). One of the challenges of cortical normative modeling is the…
Structural magnetic resonance imaging (MRI) studies have shown that Alzheimer's Disease (AD) induces both localised and widespread neural degenerative changes throughout the brain. However, the absence of segmentation that highlights brain…
Survival analysis utilizing multiple longitudinal medical images plays a pivotal role in the early detection and prognosis of diseases by providing insight beyond single-image evaluations. However, current methodologies often inadequately…
In this thesis the aim is to work on optimizing the modern machine learning models for personalized forecasting of Alzheimer Disease (AD) Progression from clinical trial data. The data comes from the TADPOLE challenge, which is one of the…
Alzheimer's disease (AD) confirmation often relies on positron emission tomography (PET) or cerebrospinal fluid (CSF) analysis, which are costly and invasive. Consequently, structural MRI biomarkers such as cortical thickness (CT) are…
Alzheimer's detection efforts aim to develop accurate models for early disease diagnosis. Significant advances have been achieved with convolutional neural networks and vision transformer based approaches. However, medical datasets suffer…
Recurrent neural networks are effective models to process sequences. However, they are unable to learn long-term dependencies because of their inherent sequential nature. As a solution, Vaswani et al. introduced the Transformer, a model…
Individualized Alzheimer's disease (AD) progression prediction requires models that use irregular visits, account for censoring, avoid diagnostic leakage, and provide calibrated horizon risks. We propose PROgression-aware MultI-horizon…
Introduction: It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer's disease (AD) dementia. Methods: A deep learning method is…
Alzheimer's is a brain disease that gets worse over time and affects memory, thinking, and behavior. Alzheimer's disease (AD) can be treated and managed if it is diagnosed early, which can slow the progression of symptoms and improve…