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The efficient calculation of rare-event kinetics in complex dynamical systems, such as the rate and pathways of ligand dissociation from a protein, is a generally unsolved problem. Markov state models can systematically integrate ensembles…

化学物理 · 物理学 2016-02-03 Benjamin Trendelkamp-Schroer , Frank Noe

We introduce a methodology for online estimation of smoothing expectations for a class of additive functionals, in the context of a rich family of diffusion processes (that may include jumps) -- observed at discrete-time instances. We…

统计计算 · 统计学 2022-07-04 Shouto Yonekura , Alexandros Beskos

We propose a novel generative model for time series based on Schr{\"o}dinger bridge (SB) approach. This consists in the entropic interpolation via optimal transport between a reference probability measure on path space and a target measure…

最优化与控制 · 数学 2023-04-12 Mohamed Hamdouche , Pierre Henry-Labordere , Huyên Pham

Performing numerical integration when the integrand itself cannot be evaluated point-wise is a challenging task that arises in statistical analysis, notably in Bayesian inference for models with intractable likelihood functions. Markov…

统计计算 · 统计学 2020-06-17 Lawrence Middleton , George Deligiannidis , Arnaud Doucet , Pierre E. Jacob

Motivated by applications in movement ecology, in this paper I propose a new class of integrated continuous-time hidden Markov models in which each observation depends on the underlying state of the process over the whole interval since the…

统计方法学 · 统计学 2019-10-01 Paul G Blackwell

For a network of discrete states with a periodically driven Markovian dynamics, we develop an inference scheme for an external observer who has access to some transitions. Based on waiting-time distributions between these transitions, the…

统计力学 · 物理学 2024-09-12 Alexander M. Maier , Julius Degünther , Jann van der Meer , Udo Seifert

For continuous-time Markov jump processes on irreducible networks with time-independent rate constants, we employ a transition-based formalism to express the long-time precision of a single integrated current over an observable channel in…

统计力学 · 物理学 2026-05-25 Alberto Garilli , Diego Frezzato

Biochemical reaction networks are an amalgamation of reactions where each reaction represents the interaction of different species. Generally, these networks exhibit a multi-scale behavior caused by the high variability in reaction rates…

定量方法 · 定量生物学 2023-04-14 Derya Altıntan , Bastian Alt , Heinz Koeppl

Piecewise-deterministic Markov processes form a general class of non-diffusion stochastic models that involve both deterministic trajectories and random jumps at random times. In this paper, we state a new characterization of the jump rate…

统计方法学 · 统计学 2017-05-03 Romain Azaïs , Alexandre Genadot

We propose a Bayesian nonparametric mixture model for the reconstruction and prediction from observed time series data, of discretized stochastic dynamical systems, based on Markov Chain Monte Carlo methods (MCMC). Our results can be used…

应用统计 · 统计学 2017-10-03 Christos Merkatas , Konstantinos Kaloudis , Spyridon J. Hatjispyros

In this paper, we equip the conventional discrete-time queueing network with a Markovian input process, that, in addition to the usual short-term stochastics, governs the mid- to long-term behavior of the links between the network nodes.…

系统与控制 · 电气工程与系统科学 2020-04-07 Richard Schoeffauer , Gerhard Wunder

The stochastic properties of a Langevin-type Markov process can be extracted from a given time series by a Markov analysis. Also processes that obey a stochastically forced second order differential equation can be analyzed this way by…

数据分析、统计与概率 · 物理学 2014-12-09 Bernd Lehle , Joachim Peinke

With increasingly more computation being shifted to the edge of the network, monitoring of critical infrastructures, such as intermediate processing nodes in autonomous driving, is further complicated due to the typically…

分布式、并行与集群计算 · 计算机科学 2023-01-31 Dominik Scheinert , Babak Sistani Zadeh Aghdam , Soeren Becker , Odej Kao , Lauritz Thamsen

This paper presents a new resolution strategy for multi-scale streamer discharge simulations based on a second order time adaptive integration and space adaptive multiresolution. A classical fluid model is used to describe plasma…

The objective of this paper is to study the filtering problem for a system of partially observable processes $(X, Y)$, where $X$ is a non-Markovian pure-jump process representing the signal and $Y$ is a general jump-diffusion which provides…

概率论 · 数学 2022-06-02 Elena Bandini , Alessandro Calvia , Katia Colaneri

This work presents a comprehensive framework for enhanced diffusion modeling in fluid-structure interactions by combining the Immersed Boundary Method (IBM) with stochastic trajectories and high-order spectral boundary conditions. Using…

偏微分方程分析 · 数学 2024-10-31 Rômulo Damasclin Chaves dos Santos , Jorge Henrique de Oliveira Sales

Multi-state models are commonly used for intermittent observations of a state over time, but these are generally based on the Markov assumption, that transition rates are independent of the time spent in current and previous states. In a…

统计方法学 · 统计学 2026-05-07 Christopher Jackson

Markov chain Monte Carlo methods are central in computational statistics, and typically rely on detailed balance to ensure invariance with respect to a target distribution. Although straightforward to construct by Metropolization, this can…

统计理论 · 数学 2025-11-14 Erik Jansson , Moritz Schauer , Ruben Seyer , Akash Sharma

This paper considers stochastic-constrained stochastic optimization where the stochastic constraint is to satisfy that the expectation of a random function is below a certain threshold. In particular, we study the setting where data samples…

最优化与控制 · 数学 2026-01-27 Yeongjong Kim , Dabeen Lee

We propose an extension with immediate multiactions of discrete time stochastic Petri Box Calculus (dtsPBC), presented by I.V. Tarasyuk. The resulting algebra dtsiPBC is a discrete time analogue of stochastic Petri Box Calculus (sPBC) with…

计算机科学中的逻辑 · 计算机科学 2017-02-27 Igor V. Tarasyuk , Hermenegilda Macià , Valentín Valero