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Biochemical signaling cascades transmit intracellular information while dissipating energy under nonequilibrium conditions. We model a cascade as a code string and apply information-entropy ideas to quantify an optimal transmission rate. A…

分子网络 · 定量生物学 2026-01-21 Tatsuaki Tsuruyama

These are notes for a set of 7 two-hour lectures given at the 2010 Summer School on Quantitative Evolutionary and Comparative Genomics at OIST, Okinawa, Japan. The emphasis is on understanding how biological systems process information. We…

分子网络 · 定量生物学 2010-06-23 Gašper Tkačik

In order to interpret and explain the physiological signal behaviors, it can be interesting to find some constants among the fluctuations of these data during all the effort or during different stages of the race (which can be detected…

应用统计 · 统计学 2011-12-06 Imen Kammoun , Véronique Billat , Jean-Marc Bardet

We provide a stochastic thermodynamic description across scales for $N$ identical units with all-to-all interactions that are driven away from equilibrium by different reservoirs and external forces. We start at the microscopic level with…

统计力学 · 物理学 2020-07-07 Tim Herpich , Tommaso Cossetto , Gianmaria Falasco , Massimiliano Esposito

We developed a new approach comprised of different visualizations for the comparative spatio-temporal analysis of displacement processes in porous media. We aim to analyze and compare ensemble datasets from experiments to gain insight into…

图形学 · 计算机科学 2024-01-17 Alexander Straub , Nikolaos Karadimitriou , Guido Reina , Steffen Frey , Holger Steeb , Thomas Ertl

A central concern across the natural sciences is a quantitative understanding of the mechanism governing rare transitions between two metastable states. Recent research has uncovered a fundamental equality between the time-reversal…

统计力学 · 物理学 2024-12-30 Miranda D. Louwerse , David A. Sivak

Characterizing the dynamic interactive patterns of complex systems helps gain in-depth understanding of how components interrelate with each other while performing certain functions as a whole. In this study, we present a novel multimodal…

机器学习 · 计算机科学 2019-01-07 Miaolin Fan , Chun-An Chou , Sheng-Che Yen , Yingzi Lin

Fracture resistance of blood clots plays a crucial role in physiological hemostasis and pathological thromboembolism. Although recent experimental and computational studies uncovered the poro-viscoelastic property of blood clots and its…

医学物理 · 物理学 2024-06-26 Dongxu Liu , Nhung Nguyen , Tinh Quoc Bui , Luka Pocivavsek

The central nervous system is composed of many individual units -- from cells to areas -- that are connected with one another in a complex pattern of functional interactions that supports perception, action, and cognition. One natural and…

神经元与认知 · 定量生物学 2017-04-03 Ann E. Sizemore , Danielle S. Bassett

In this paper, we prove the existence of fundamental relations between information theory and estimation theory for network-coded flows. When the network is represented by a directed graph G=(V, E) and under the assumption of uncorrelated…

信息论 · 计算机科学 2016-11-17 Samah A. M. Ghanem

We extend the N-Intertwined Mean-Field Approximation (NIMFA) for the Susceptible-Infectious-Susceptible (SIS) epidemiological process to time-varying networks. Processes on time-varying networks are often analysed under the assumption that…

动力系统 · 数学 2024-04-11 Robin Persoons , Mattia Sensi , Bastian Prasse , Piet Van Mieghem

Network science enables the effective analysis of real interconnected systems, characterized by a complex interplay between topology and interconnections strength. It is well-known that the topology of a network affects its resilience to…

物理与社会 · 物理学 2021-06-10 Giulia Bertagnolli , Riccardo Gallotti , Manlio De Domenico

Dynamic functional connectivity (DFC) analysis involves measuring correlated neural activity over time across multiple brain regions. Significant regional correlations among neural signals, such as those obtained from resting-state…

One of the fundamental steps toward understanding a complex system is identifying variation at the scale of the system's components that is most relevant to behavior on a macroscopic scale. Mutual information provides a natural means of…

机器学习 · 计算机科学 2024-03-20 Kieran A. Murphy , Dani S. Bassett

Multivariate dynamic time series models are widely encountered in practical studies, e.g., modelling policy transmission mechanism and measuring connectedness between economic agents. To better capture the dynamics, this paper proposes a…

计量经济学 · 经济学 2020-10-06 Yayi Yan , Jiti Gao , Bin Peng

Prenatal maternal stress (PS) is a risk factor for adverse offspring neurodevelopment. Heart rate variability (HRV) complexity provides a non-invasive marker of maternal autonomic regulation and may be influenced by mind--body interventions…

During time evolution of many-body systems entanglement grows rapidly, limiting exact simulations to small-scale systems or small timescales. Quantum information tends however to flow towards larger scales without returning to local scales,…

We present a topological framework for analysing neural time series that integrates Transfer Entropy (TE) with directed Persistent Homology (PH) to characterize information flow in spiking neural systems. TE quantifies directional influence…

神经元与认知 · 定量生物学 2025-08-27 Dylan Peek , Siddharth Pritam , Matthew P. Skerritt , Stephan Chalup

Man-made communications signals are typically modelled as continuous-time (CT) wide-sense cyclostationary (WSCS) processes. As modern processing is digital, it operates on sampled versions of the CT signals. When sampling is applied to a CT…

信息论 · 计算机科学 2020-04-22 Emeka Abakasanga , Nir Shlezinger , Ron Dabora

Microscopic biological systems operate far from equilibrium, are subject to strong fluctuations, and are composed of many coupled components with interactions varying in nature and strength. Researchers are actively investigating the…

统计力学 · 物理学 2023-12-25 Emma Lathouwers , David A. Sivak
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