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In network meta-analysis (NMA), we synthesize all relevant evidence about health outcomes with competing treatments. The evidence may come from randomized controlled trials (RCT) or non-randomized studies (NRS) as individual participant…

In paired randomized experiments individuals in a given matched pair may differ on prognostically important covariates despite the best efforts of practitioners. We examine the use of regression adjustment as a way to correct for persistent…

统计方法学 · 统计学 2017-11-27 Colin B. Fogarty

Scientists often use meta-analysis to characterize the impact of an intervention on some outcome of interest across a body of literature. However, threats to the utility and validity of meta-analytic estimates arise when scientists average…

人机交互 · 计算机科学 2023-02-21 Alex Kale , Sarah Lee , Terrance Goan , Elizabeth Tipton , Jessica Hullman

We consider inference in linear regression models that is robust to heteroskedasticity and the presence of many control variables. When the number of control variables increases at the same rate as the sample size the usual…

统计理论 · 数学 2020-09-29 Koen Jochmans

Traditional mediation analysis typically examines the relations among an intervention, a time-invariant mediator, and a time-invariant outcome variable. Although there may be a direct effect of the intervention on the outcome, there is a…

应用统计 · 统计学 2020-08-28 Xizhen Cai , Donna L. Coffman , Megan E. Piper , Runze Li

Meta-analysis is a powerful tool for assessing drug safety by combining treatment-related toxicological findings across multiple studies, as clinical trials are typically underpowered for detecting adverse drug effects. However, incomplete…

统计方法学 · 统计学 2024-02-12 Xinyue Qi , Shouhao Zhou , Christine B. Peterson , Yucai Wang , Xinying Fang , Michael L. Wang , Chan Shen

Interventional effects have been proposed as a solution to the unidentifiability of natural (in)direct effects under mediator-outcome confounders affected by the exposure. Such confounders are an intrinsic characteristic of studies with…

统计方法学 · 统计学 2022-03-30 Iván Díaz , Nicholas Williams , Kara E. Rudolph

Meta-learning involves training models on a variety of training tasks in a way that enables them to generalize well on new, unseen test tasks. In this work, we consider meta-learning within the framework of high-dimensional multivariate…

统计理论 · 数学 2024-04-01 Yanhao Jin , Krishnakumar Balasubramanian , Debashis Paul

To investigate intervention effects on rare events, meta-analysis techniques are commonly applied in order to assess the accumulated evidence. When it comes to adverse effects in clinical trials, these are often most adequately handled…

统计方法学 · 统计学 2026-04-03 Christian Röver , Qiong Wu , Anja Loos , Tim Friede

Mediation analysis is a form of causal inference that investigates indirect effects and causal mechanisms. Confidence intervals for indirect effects play a central role in conducting inference. The problem is non-standard leading to…

计量经济学 · 经济学 2024-12-17 Kees Jan van Garderen , Noud van Giersbergen

Accurately quantifying uncertainty of individual treatment effects (ITEs) across multiple decision points is crucial for personalized decision-making in fields such as healthcare, finance, education, and online marketplaces. Previous work…

统计方法学 · 统计学 2025-12-10 Swaraj Bose , Walter Dempsey

Uncertainties in a structure is inevitable, which generally lead to variation in dynamic response predictions. For a complex structure, brute force Monte Carlo simulation for response variation analysis is infeasible since one single run…

机器学习 · 统计学 2020-05-08 Kai Zhou , Jiong Tang

Investigators often use multi-source data (e.g., multi-center trials, meta-analyses of randomized trials, pooled analyses of observational cohorts) to learn about the effects of interventions in subgroups of some well-defined target…

统计方法学 · 统计学 2024-02-06 Guanbo Wang , Alexander Levis , Jon Steingrimsson , Issa Dahabreh

By employing various empirical estimators for the Mutual Information (MI) measure, we calculate and compare the estimates and their confidence intervals for both normal and non-normal bivariate data samples. We find that certain nonlinear…

信息论 · 计算机科学 2024-10-10 Theo Grigorenko , Leo Grigorenko

Experimenters often collect baseline data to study heterogeneity. I propose the first valid confidence intervals for the VCATE, the treatment effect variance explained by observables. Conventional approaches yield incorrect coverage when…

计量经济学 · 经济学 2023-06-07 Alejandro Sanchez-Becerra

We provide a unified approach to a method of estimation of the regression parameter in balanced linear models with a structured covariance matrix that combines a high breakdown point and bounded influence with high asymptotic efficiency at…

统计理论 · 数学 2023-03-22 Hendrik Paul Lopuhaä

In this paper, we investigate the impact of test-time adversarial attacks on linear regression models and determine the optimal level of robustness that any model can reach while maintaining a given level of standard predictive performance…

机器学习 · 统计学 2023-08-02 Elvis Dohmatob , Meyer Scetbon

Measuring treatment effects in observational studies is challenging because of confounding bias. Confounding occurs when a variable affects both the treatment and the outcome. Traditional methods such as propensity score matching estimate…

统计方法学 · 统计学 2021-12-23 Bevan I. Smith , Charles Chimedza

Test-time interventions for language models can enhance factual accuracy, mitigate harmful outputs, and improve model efficiency without costly retraining. But despite a flood of new methods, different types of interventions are largely…

A stepped wedge design is a unidirectional crossover design where clusters are randomized to distinct treatment sequences. While model-based analysis of stepped wedge designs is standard practice to evaluate treatment effects accounting for…

统计方法学 · 统计学 2024-09-13 Bingkai Wang , Xueqi Wang , Fan Li