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Critical goals of scientific computing are to increase scientific rigor, reproducibility, and transparency while keeping up with ever-increasing computational demands. This work presents an integrated framework well-suited for data…

分布式、并行与集群计算 · 计算机科学 2023-10-13 Paul Nuyujukian

To increase performance and efficiency, systems use FPGAs as reconfigurable accelerators. A key challenge in designing these systems is partitioning computation between processors and an FPGA. An appropriate division of labor may be…

硬件体系结构 · 计算机科学 2021-07-21 Endri Bezati , Mahyar Emami , Jörn Janneck , James Larus

Lakehouses are now the default substrate for analytics and AI, but they remain fragile under concurrent, untrusted change: schema mismatches often surface only at runtime, development and production easily diverge, and multi-table pipelines…

分布式、并行与集群计算 · 计算机科学 2026-03-18 Weiming Sheng , Jinlang Wang , Manuel Barros , Aldrin Montana , Jacopo Tagliabue , Luca Bigon

In year 2006 Bio-Linux with the work of Tim Booth and team gives its rising and provide an operating system that was and still specialized in providing a bioinformatic specific software environment for the working needs in this corner of…

操作系统 · 计算机科学 2013-10-08 Sasa Paporovic

As spatial and temporal resolutions of scientific instruments improve, the explosion in the volume of data produced is becoming a key challenge. It can be a critical bottleneck for integration between scientific instruments at the edge and…

仪器与探测器 · 物理学 2021-11-03 Kazutomo Yoshii , Rajesh Sankaran , Sebastian Strempfer , Maksim Levental , Mike Hammer , Antonino Miceli

The current trend for domain-specific architectures (DSAs) has led to renewed interest in research test chips to demonstrate new specialized hardware. Tape-outs also offer huge pedagogical value garnered from real hands-on exposure to the…

硬件体系结构 · 计算机科学 2020-05-27 Paul Whatmough , Marco Donato , Glenn Ko , Sae-Kyu Lee , David Brooks , Gu-Yeon Wei

This paper aims to create a transition path from file-based IO to streaming-based workflows for scientific applications in an HPC environment. By using the openPMP-api, traditional workflows limited by filesystem bottlenecks can be overcome…

The ubiquity of computation in modern scientific research inflicts new challenges for reproducibility. While most journals now require code and data be made available, the standards for organization, annotation, and validation remain lax,…

其他定量生物学 · 定量生物学 2022-10-07 Griffin Chure

Omics software tools have reshaped the landscape of modern biology and become an essential component of biomedical research. The increasing dependence of biomedical scientists on these powerful tools creates a need for easier installation…

To reduce the carbon footprint of computing and stabilize electricity grids, there is an increasing focus on approaches that align the power usage of IT infrastructure with the availability of clean energy. Unfortunately, research on…

分布式、并行与集群计算 · 计算机科学 2024-06-21 Philipp Wiesner , Ilja Behnke , Paul Kilian , Marvin Steinke , Odej Kao

When designing new web applications, developers must cope with different kinds of constraints relative to the resources they rely on: software, hardware, network, online micro-services, or any combination of the mentioned entities.…

编程语言 · 计算机科学 2026-02-06 Anna Gallone , Simon Bliudze , Sophie Cerf , Olga Kouchnarenko

Time-series learning is the bread and butter of data-driven *clinical decision support*, and the recent explosion in ML research has demonstrated great potential in various healthcare settings. At the same time, medical time-series problems…

机器学习 · 计算机科学 2023-10-31 Daniel Jarrett , Jinsung Yoon , Ioana Bica , Zhaozhi Qian , Ari Ercole , Mihaela van der Schaar

Proof autoformalization, the task of translating natural language theorems and proofs into machine-verifiable code, is a critical step for integrating large language models into rigorous mathematical workflows. Current approaches focus on…

人工智能 · 计算机科学 2025-10-21 Rafael Cabral , Tuan Manh Do , Xuejun Yu , Wai Ming Tai , Zijin Feng , Xin Shen

Building multiscale biological models requires integrating independently developed submodels, which involves sharing variables and coordinating execution. Most existing tools focus on isolated mechanisms and numerical methods, but rarely…

定量方法 · 定量生物学 2026-01-01 Eran Agmon , Ryan K Spangler

Logs are a common way to record detailed run-time information in software. As modern software systems evolve in scale and complexity, logs have become indispensable to understanding the internal states of the system. At the same time…

机器学习 · 计算机科学 2021-03-15 Armin Catovic , Carolyn Cartwright , Yasmin Tesfaldet Gebreyesus , Simone Ferlin

Difficulty replicating baselines, high computational costs, and required domain expertise create persistent barriers to clinical AI research. To address these challenges, we introduce PyHealth 2.0, an enhanced clinical deep learning toolkit…

Successful data-driven science requires complex data engineering pipelines to clean, transform, and alter data in preparation for machine learning, and robust results can only be achieved when each step in the pipeline can be justified, and…

数据库 · 计算机科学 2024-04-08 Adriane Chapman , Luca Lauro , Paolo Missier , Riccardo Torlone

Unorganized heaps of analysis code are a growing liability as data analysis pipelines are getting longer and more complicated. This is worrying, as neuroscience papers are getting retracted due to programmer error. In this paper, some…

软件工程 · 计算机科学 2019-08-12 Marijn van Vliet

The increasing risk of epidemics and a fast-growing world population has contributed to a great investment in phylogenetic analysis, in order to track numerous diseases and conceive effective medication and treatments. Phylogenetic analysis…

社会与信息网络 · 计算机科学 2022-11-29 Miguel Luis , Catia Vaz

In year 2006 Biolinux inter alia with the work of Tim Booth gives its rise and provide an operating system that was and is specialized in providing an environment for the needs of bioinformatics. Since than some years have been seen and the…

计算机与社会 · 计算机科学 2013-05-21 Sasa Paporovic