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The primary analysis of clinical trials in diabetes therapeutic area often involves a mixed-model repeated measure (MMRM) approach to estimate the average treatment effect for longitudinal continuous outcome, and a generalized linear mixed…

应用统计 · 统计学 2022-08-03 Lingjing Jiang , Michael Rosenblum , Yu Du

Semi- and non-parametric mixture of regressions are a very useful flexible class of mixture of regressions in which some or all of the parameters are non-parametric functions of the covariates. These models are, however, based on the…

统计方法学 · 统计学 2026-01-13 Sphiwe B. Skhosana , Weixin Yao

We propose the Gaussian-Linear Hidden Markov model (GLHMM), a generalisation of different types of HMMs commonly used in neuroscience. In short, the GLHMM is a general framework where linear regression is used to flexibly parameterise the…

We propose an L1-penalized algorithm for fitting high-dimensional generalized linear mixed models. Generalized linear mixed models (GLMMs) can be viewed as an extension of generalized linear models for clustered observations. This…

统计计算 · 统计学 2014-06-03 Jürg Schelldorfer , Lukas Meier , Peter Bühlmann

Researchers are increasingly turning to machine learning (ML) algorithms to investigate causal heterogeneity in randomized experiments. Despite their promise, ML algorithms may fail to accurately ascertain heterogeneous treatment effects…

统计方法学 · 统计学 2024-04-23 Kosuke Imai , Michael Lingzhi Li

We propose a modified version of the three-step estimation method for the latent class model with covariates, which may be used to estimate latent Markov models for longitudinal data. The three-step estimation approach we propose is based…

统计方法学 · 统计学 2014-02-06 Francesco Bartolucci , Giorgio E. Montanari , Silvia Pandolfi

Stochastic volatility models are the backbone of financial engineering. We study both continuous time diffusions as well as discrete time models. We propose two novel approaches to estimating stochastic volatility diffusions, one using…

量子物理 · 物理学 2025-07-30 Eric Ghysels , Jack Morgan , Hamed Mohammadbagherpoor

We consider a linear mixed-effects model with a clustered structure, where the parameters are estimated using maximum likelihood (ML) based on possibly unbalanced data. Inference with this model is typically done based on asymptotic theory,…

统计理论 · 数学 2021-03-30 Chih-Hao Chang , Hsin-Cheng Huang , Ching-Kang Ing

This paper focuses on the multivariate linear mixed-effects model, including all the correlations between the random effects when the marginal residual terms are assumed uncorrelated and homoscedastic with possibly different standard…

统计方法学 · 统计学 2017-05-04 Eric Adjakossa , Grégory Nuel

High-dimensional datasets are frequently subject to contamination by outliers and heavy-tailed noise, which can severely bias standard regularized estimators like the Lasso. While Maximum Mean Discrepancy (MMD) has recently been introduced…

统计方法学 · 统计学 2026-02-25 Xiaoning Kang , Lulu Kang

Large language models (LLMs) are increasingly used in statistical research and applications. However,they are also notorious for unreliable or biased information. Here, we explore whether LLMs can be used to improve the precision of…

应用统计 · 统计学 2026-05-29 Jaylin Lowe , Adam Sales , Johann A. Gagnon-Bartsch

Expectation-Maximization (EM) algorithm is a widely used iterative algorithm for computing (local) maximum likelihood estimate (MLE). It can be used in an extensive range of problems, including the clustering of data based on the Gaussian…

机器学习 · 统计学 2023-03-28 Pierre Houdouin , Esa Ollila , Frederic Pascal

Currently, machine learning (ML) methods are widely used to process the results of physical experiments. In some cases, due to the limited amount of experimental data, ML-models can be pre-trained on synthetic data simulated based on the…

计算物理 · 物理学 2022-09-22 Y. R. Rodimkov , V. D. Volokitin , I. B. Meyerov , E. S. Efimenko

Do expert-defined or diagnostically-labeled data groups align with clusters inferred through statistical modeling? If not, where do discrepancies between predefined labels and model-based groupings occur and why? In this work, we introduce…

统计方法学 · 统计学 2026-03-18 Patricia Puchhammer , Ines Wilms , Peter Filzmoser

Frailty models are often the model of choice for heterogeneous survival data. A frailty model contains both random effects and fixed effects, with the random effects accommodating for the correlation in the data. Different estimation…

统计方法学 · 统计学 2019-09-17 Oodally Ajmal , Luc Duchateau , Estelle Kuhn

We introduce a Bayesian approach for analyzing high-dimensional multinomial data that are referenced over space and time. In particular, the proportions associated with multinomial data are assumed to have a logit link to a latent…

统计方法学 · 统计学 2018-12-11 Jonathan R. Bradley , Christopher K. Wikle , Scott H. Holan

In this paper, a new mixture family of multivariate normal distributions, formed by mixing multivariate normal distribution and skewed distribution, is constructed. Some properties of this family, such as characteristic function, moment…

统计方法学 · 统计学 2020-09-24 Me'raj Abdi , Mohsen Madadi , N. Balakrishnan , Ahad Jamalizadeh

Traffic prediction, an essential component for intelligent transportation systems, endeavours to use historical data to foresee future traffic features at specific locations. Although existing traffic prediction models often emphasize…

机器学习 · 计算机科学 2024-07-09 Chenxi Liu , Sun Yang , Qianxiong Xu , Zhishuai Li , Cheng Long , Ziyue Li , Rui Zhao

Works in quantum machine learning (QML) over the past few years indicate that QML algorithms can function just as well as their classical counterparts, and even outperform them in some cases. Among the corpus of recent work, many current…

机器学习 · 计算机科学 2023-05-18 Joseph Lindsay , Ramtin Zand

The functional linear model is a popular tool to investigate the relationship between a scalar/functional response variable and a scalar/functional covariate. We generalize this model to a functional linear mixed-effects model when repeated…

统计方法学 · 统计学 2016-01-07 Baisen Liu , Jiguo Cao