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We develop three efficient approaches for generating visual explanations from 3D convolutional neural networks (3D-CNNs) for Alzheimer's disease classification. One approach conducts sensitivity analysis on hierarchical 3D image…

计算机视觉与模式识别 · 计算机科学 2018-07-09 Chengliang Yang , Anand Rangarajan , Sanjay Ranka

Current Computer-Aided Diagnosis (CAD) methods mainly depend on medical images. The clinical information, which usually needs to be considered in practical clinical diagnosis, has not been fully employed in CAD. In this paper, we propose a…

图像与视频处理 · 电气工程与系统科学 2021-03-11 Songxiao Yang , Xiabi Liu , Zhongshu Zheng , Wei Wang , Xiaohong Ma

Recent advances in experimental methods have enabled researchers to collect data on thousands of analytes simultaneously. This has led to correlational studies that associated molecular measurements with diseases such as Alzheimer's, Liver,…

定量方法 · 定量生物学 2024-05-20 Divyagna Bavikadi , Ayushi Agarwal , Shashank Ganta , Yunro Chung , Lusheng Song , Ji Qiu , Paulo Shakarian

Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disease which destroys brain cells and causes loss to patient's memory. An early detection can prevent the patient from further damage of the brain cells and hence…

图像与视频处理 · 电气工程与系统科学 2021-01-11 Ali Nawaz , Syed Muhammad Anwar , Rehan Liaqat , Javid Iqbal , Ulas Bagci , Muhammad Majid

For a learning task, data can usually be collected from different sources or be represented from multiple views. For example, laboratory results from different medical examinations are available for disease diagnosis, and each of them can…

机器学习 · 计算机科学 2018-03-28 Bokai Cao , Hucheng Zhou , Guoqiang Li , Philip S. Yu

Multi-view data clustering attracts more attention than their single view counterparts due to the fact that leveraging multiple independent and complementary information from multi-view feature spaces outperforms the single one. Multi-view…

计算机视觉与模式识别 · 计算机科学 2017-12-08 Yang Wang , Lin Wu

Alzheimer's Disease Neuroimaging Initiative (ADNI) diagnostic groups present strong heterogeneous associations among demographic, imaging, and cognitive data. We propose a novel PArtially-shared Imaging Regression (PAIR) model to represent…

统计方法学 · 统计学 2026-05-01 Yang Sui , Qi Xu , Ting Li , Yang Bai , Annie Qu

Machine Learning (ML) has emerged as a promising approach in healthcare, outperforming traditional statistical techniques. However, to establish ML as a reliable tool in clinical practice, adherence to best practices regarding data…

图像与视频处理 · 电气工程与系统科学 2023-09-15 Rosanna Turrisi , Alessandro Verri , Annalisa Barla

In many machine learning problems, labeled training data is limited but unlabeled data is ample. Some of these problems have instances that can be factored into multiple views, each of which is nearly sufficent in determining the correct…

机器学习 · 计算机科学 2012-06-18 Kuzman Ganchev , Joao Graca , John Blitzer , Ben Taskar

Alzheimer's disease is characterized by alterations of the brain's structural and functional connectivity during its progressive degenerative processes. Existing auxiliary diagnostic methods have accomplished the classification task, but…

机器学习 · 计算机科学 2021-10-19 Qiankun Zuo , Baiying Lei , Shuqiang Wang , Yong Liu , Bingchuan Wang , Yanyan Shen

In recent years, we have witnessed a surge of interest in multi-view representation learning, which is concerned with the problem of learning representations of multi-view data. When facing multiple views that are highly related but sightly…

机器学习 · 计算机科学 2020-06-20 Xiangzhu Meng , Lin Feng , Huibing Wang

Current neuroimaging techniques provide paths to investigate the structure and function of the brain in vivo and have made great advances in understanding Alzheimer's disease (AD). However, the group-level analyses prevalently used for…

定量方法 · 定量生物学 2021-05-31 Nanyan Zhu , Chen Liu , Xinyang Feng , Dipika Sikka , Sabrina Gjerswold-Selleck , Scott A. Small , Jia Guo

Multimodal neuroimage can provide complementary information about the dementia, but small size of complete multimodal data limits the ability in representation learning. Moreover, the data distribution inconsistency from different…

计算机视觉与模式识别 · 计算机科学 2021-07-22 Qiankun Zuo , Baiying Lei , Yanyan Shen , Yong Liu , Zhiguang Feng , Shuqiang Wang

Multi-view learning leverages correlations between different sources of data to make predictions in one view based on observations in another view. A popular approach is to assume that, both, the correlations between the views and the…

机器学习 · 计算机科学 2014-04-29 Behrouz Behmardi , Cedric Archambeau , Guillaume Bouchard

An interpretable machine learning (ML) framework is introduced to enhance the diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) by ensuring robustness of the ML models' interpretations. The dataset used comprises…

Alzheimer's disease is one of the most common types of neurodegenerative disease, characterized by the accumulation of amyloid-beta plaque and tau tangles. Recently, deep learning approaches have shown promise in Alzheimer's disease…

图像与视频处理 · 电气工程与系统科学 2024-07-03 Gia Minh Hoang , Youngjoo Lee , Jae Gwan Kim

Detection of Alzheimer's Disease (AD) from neuroimaging data such as MRI through machine learning have been a subject of intense research in recent years. Recent success of deep learning in computer vision have progressed such research…

计算机视觉与模式识别 · 计算机科学 2017-12-01 Marcia Hon , Naimul Khan

Conventional multi-view clustering methods seek for a view consensus through minimizing the pairwise discrepancy between the consensus and subviews. However, the pairwise comparison cannot portray the inter-view relationship precisely if…

机器学习 · 计算机科学 2020-05-13 Zhe Liu , Yun Li , Lina Yao , Xianzhi Wang , Feiping Nie

Computer-aided early diagnosis of Alzheimers Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research in recent years. Some recent studies have shown promising results in the AD and…

计算机视觉与模式识别 · 计算机科学 2018-01-19 Alexander Khvostikov , Karim Aderghal , Jenny Benois-Pineau , Andrey Krylov , Gwenaelle Catheline

Alzheimer's disease (AD) diagnosis requires integrating neuroimaging with heterogeneous clinical evidence and reasoning under established criteria, yet most multimodal models remain opaque and weakly guideline-aligned. We present…

计算机视觉与模式识别 · 计算机科学 2026-03-26 Qiuhui Chen , Yushan Deng , Xuancheng Yao , Yi Hong